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Chemoenzymatic and template-directed synthesis of bioactive macrocyclic peptides

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Europe PubMed Central

PMC publication ID

14 August 2017

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Europe PubMed Central

Chemoenzymatic and template-directed synthesis of bioactive macrocyclic peptides (English)

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Europe PubMed Central

PMC publication ID

14 August 2017

author name string

Jan Grünewald

1

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Europe PubMed Central

PMC publication ID

14 August 2017

Mohamed A Marahiel

2

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Europe PubMed Central

PMC publication ID

14 August 2017

publication date

1 March 2006

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Europe PubMed Central

PMC publication ID

14 August 2017

Microbiology and Molecular Biology Reviews

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Europe PubMed Central

PMC publication ID

14 August 2017

70

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Europe PubMed Central

PMC publication ID

14 August 2017

1

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

121-146

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

The lipopeptide antibiotic A54145 biosynthetic gene cluster from Streptomyces fradiae

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1 reference

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1 reference

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1 reference

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Bioactive microbial metabolites

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Portability of oxidase domains in nonribosomal peptide synthetase modules.

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Enhanced macrocyclizing activity of the thioesterase from tyrocidine synthetase in presence of nonionic detergent.

1 reference

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Biosynthesis of nonribosomal peptides1.

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Enzyme catalysed deracemisation and dynamic kinetic resolution reactions

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Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteria

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Polyketide and nonribosomal peptide antibiotics: modularity and versatility

1 reference

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The linear pentadecapeptide gramicidin is assembled by four multimodular nonribosomal peptide synthetases that comprise 16 modules with 56 catalytic domains

1 reference

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1 reference

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Learning from nature's drug factories: nonribosomal synthesis of macrocyclic peptides

1 reference

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The structure of docking domains in modular polyketide synthases

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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21 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Chimeric streptogramin-tyrocidine antibiotics that overcome streptogramin resistance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Molecular mechanisms underlying nonribosomal peptide synthesis: approaches to new antibiotics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Synthesis and derivatization of daptomycin: a chemoenzymatic route to acidic lipopeptide antibiotics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

An oxidative phenol coupling reaction catalyzed by oxyB, a cytochrome P450 from the vancomycin-producing microorganism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

A chemoenzymatic approach to glycopeptide antibiotics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Metabolic flux analysis for calcium dependent antibiotic (CDA) production in Streptomyces coelicolor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Type II thioesterase restores activity of a NRPS module stalled with an aminoacyl-S-enzyme that cannot be elongated.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Daptomycin structure and mechanism of action revealed.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Specific labeling of cell surface proteins with chemically diverse compounds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Enzymatic cyclisation of peptidomimetics with incorporated (E)-alkene dipeptide isosteres.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

NMR structure determination and calcium binding effects of lipopeptide antibiotic daptomycin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Labeling proteins with small molecules by site-specific posttranslational modification.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Rational design of a bimodular model system for the investigation of heterocyclization in nonribosomal peptide biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Manipulation of carrier proteins in antibiotic biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Active-site modifications of adenylation domains lead to hydrolysis of upstream nonribosomal peptidyl thioester intermediates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Chemo- and regioselective peptide cyclization triggered by the N-terminal fatty acid chain length: the recombinant cyclase of the calcium-dependent antibiotic from Streptomyces coelicolor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Peptidyl thiophenols as substrates for nonribosomal peptide cyclases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Array synthesis of novel lipodepsipeptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Synthesis and biological activity of N-Acylated ornithine analogues of daptomycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Loading peptidyl-coenzyme A onto peptidyl carrier proteins: a novel approach in characterizing macrocyclization by thioesterase domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Oxidase domains in epothilone and bleomycin biosynthesis: thiazoline to thiazole oxidation during chain elongation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Ebony, a novel nonribosomal peptide synthetase for beta-alanine conjugation with biogenic amines in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Bromobalhimycin and chlorobromobalhimycins--illuminating the potential of halogenases in glycopeptide antibiotic biosyntheses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

The first direct characterization of a high-valent iron intermediate in the reaction of an alpha-ketoglutarate-dependent dioxygenase: a high-spin FeIV complex in taurine/alpha-ketoglutarate dioxygenase (TauD) from Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Clorobiocin biosynthesis in Streptomyces: identification of the halogenase and generation of structural analogs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Characterization of the surfactin synthetase C-terminal thioesterase domain as a cyclic depsipeptide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Fluorobalhimycin--a new chapter in glycopeptide antibiotic research

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Decreasing the ring size of a cyclic nonribosomal peptide antibiotic by in-frame module deletion in the biosynthetic genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Timing of epimerization and condensation reactions in nonribosomal peptide assembly lines: kinetic analysis of phenylalanine activating elongation modules of tyrocidine synthetase B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908: function of a halogenase and a haloperoxidase/perhydrolase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Mutational analysis of the C-domain in nonribosomal peptide synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Epothilone biosynthesis: assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Multimodular biocatalysts for natural product assembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Cyclization of backbone-substituted peptides catalyzed by the thioesterase domain from the tyrocidine nonribosomal peptide synthetase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

The dhb operon of Bacillus subtilis encodes the biosynthetic template for the catecholic siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Purification and characterization of eucaryotic alanine racemase acting as key enzyme in cyclosporin biosynthesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Expression of an active adenylate-forming domain of peptide synthetases corresponding to acyl-CoA-synthetases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

A54145, a new lipopeptide antibiotic complex: discovery, taxonomy, fermentation and HPLC.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 September 2018

Fluorescence resonance energy transfer as a probe of peptide cyclization catalyzed by nonribosomal thioesterase domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393257

21 October 2018

Chirality of Peptide Bond-Forming Condensation Domains in Nonribosomal Peptide Synthetases: The C5 Domain of Tyrocidine Synthetase Is a DCL Catalyst

1 reference

https://pubmed.ncbi.nlm.nih.gov/16524919

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymatic and chemical modifications of lipopeptide antibiotic A21978C: the synthesis and evaluation of daptomycin (LY146032)

1 reference

https://pubmed.ncbi.nlm.nih.gov/16524919

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rational Design of Peptide Antibiotics by Targeted Replacement of Bacterial and Fungal Domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/16524919

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Biosynthesis of Vancomycin-Type Glycopeptide Antibiotics-The Order of the Cyclization Steps This work was supported by the Deutsche Forschungsgemeinschaft (SFB 323) and by a grant of the EU (MEGATOP, QLK3-1999-00650). R. D. S. gratefully acknowl

1 reference

https://pubmed.ncbi.nlm.nih.gov/16524919

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aminoacyl-CoAs as probes of condensation domain selectivity in nonribosomal peptide synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16524919

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and structure determination of nostocyclopeptides A1 and A2 from the terrestrial cyanobacterium Nostoc sp. ATCC53789

1 reference

https://pubmed.ncbi.nlm.nih.gov/16524919

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of bacitracin to cells and protoplasts of Micrococcus lysodeikticus

1 reference

https://pubmed.ncbi.nlm.nih.gov/16524919

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical characterization of peptidyl carrier protein (PCP), the thiolation domain of multifunctional peptide synthetases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16524919

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disruption of the cyclosporin synthetase gene of Tolypocladium niveum

1 reference

https://pubmed.ncbi.nlm.nih.gov/16524919

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted alteration of the substrate specificity of peptide synthetases by rational module swapping

1 reference

https://pubmed.ncbi.nlm.nih.gov/16524919

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutational analysis of the epimerization domain in the initiation module PheATE of gramicidin S synthetase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16524919

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3-Methylaspartate ammonia-lyase as a marker enzyme of the mesaconate pathway for ( S )-glutamate fermentation in Enterobacteriaceae

1 reference

https://pubmed.ncbi.nlm.nih.gov/16524919

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis of the enediyne antitumor antibiotic C-1027

1 reference

https://pubmed.ncbi.nlm.nih.gov/16524919

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A54145, a new lipopeptide antibiotic complex: isolation and characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/16524919

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New compounds by combining "modern" genomics and "old-fashioned" mutasynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16524919

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Friulimicins. Novel Lipopeptide Antibiotics with Peptidoglycan Synthesis Inhibiting Activity from Actinoplanes friuliensis sp. nov. II. Isolation and Structural Characterization.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.53.816

New Advances in the Biosynthesis of Glycopeptide Antibiotics of the Vancomycin Type fromAmycolatopsis mediterranei

1 reference

11 May 2024

https://opencitations.net/index/api/v1/citations/10.1002/(SICI)1521-3773(19990712)38:13/14%3C1976::AID-ANIE1976%3E3.0.CO;2-3

Identifiers

10.1128/MMBR.70.1.121-146.2006

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

ResearchGate publication ID

0 references

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