(Q36267887)

13 August 2017

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title

Viral and cellular RNA helicases as antiviral targets (English)

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13 August 2017

Ann D Kwong

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13 August 2017

B Govinda Rao

series ordinal

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13 August 2017

Kuan-Teh Jeang

series ordinal

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13 August 2017

publication date

1 October 2005

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Nature Reviews Drug Discovery

13 August 2017

published in

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13 August 2017

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13 August 2017

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13 August 2017

page(s)

845-853

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Antivirals and antiviral strategies

13 August 2017

cites work

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Strategies in the design of antiviral drugs

31 March 2020

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The implications of drug resistance for strategies of combination antiviral chemotherapy.

31 March 2020

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Mechanisms of helicase-catalyzed DNA unwinding

31 March 2020

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Unwinding the 'Gordian knot' of helicase action.

31 March 2020

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Modularity and specialization in superfamily 1 and 2 helicases

31 March 2020

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Helicases: amino acid sequence comparisons and structure-function relationships

31 March 2020

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Helicase structure and mechanism

31 March 2020

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Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding

31 March 2020

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Crystal structure of a DExx box DNA helicase

31 March 2020

1 reference

31 March 2020

Birth of the D-E-A-D box

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RNA chaperones exist and DEAD box proteins get a life

31 March 2020

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DExD/H box RNA helicases: from generic motors to specific dissociation functions

31 March 2020

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The protein family of RNA helicases

31 March 2020

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mRNA export: travelling with DEAD box proteins

31 March 2020

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Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families.

31 March 2020

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Hrp1, a sequence-specific RNA-binding protein that shuttles between the nucleus and the cytoplasm, is required for mRNA 3′-end formation in yeast

31 March 2020

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Messenger-RNA-binding proteins and the messages they carry

31 March 2020

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Protein displacement by DExH/D "RNA helicases" without duplex unwinding

31 March 2020

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DEAD-box proteins: the driving forces behind RNA metabolism

31 March 2020

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Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export

31 March 2020

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Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p

31 March 2020

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Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function

31 March 2020

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Dbp7p, a putative ATP-dependent RNA helicase from Saccharomyces cerevisiae, is required for 60S ribosomal subunit assembly

31 March 2020

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The rRNA-processing function of the yeast U14 small nucleolar RNA can be rescued by a conserved RNA helicase-like protein

31 March 2020

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Evolution and taxonomy of positive-strand RNA viruses: implications of comparative analysis of amino acid sequences

31 March 2020

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A DEAD box protein facilitates HIV-1 replication as a cellular co-factor of Rev.

31 March 2020

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New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease

31 March 2020

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New anti-HSV therapeutics target the helicase-primase complex

31 March 2020

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Helicases as antiviral drug targets

31 March 2020

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Papillomavirus E1 proteins: form, function, and features

31 March 2020

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A tale of two HSV-1 helicases: roles of phage and animal virus helicases in DNA replication and recombination

31 March 2020

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Herpes simplex virus 1 helicase-primase: a complex of three herpes-encoded gene products

31 March 2020

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Inhibition of herpes simplex virus type 1 helicase-primase by (dichloroanilino)purines and -pyrimidines

31 March 2020

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Potent in vivo antiviral activity of the herpes simplex virus primase-helicase inhibitor BAY 57-1293.

31 March 2020

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Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide

31 March 2020

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Structure of the hepatitis C virus RNA helicase domain

31 March 2020

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Crystal structure of RNA helicase from genotype 1b hepatitis C virus. A feasible mechanism of unwinding duplex RNA

31 March 2020

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Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

31 March 2020

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Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides

31 March 2020

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31 March 2020

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Inhibition of native hepatitis C virus replicase by nucleotide and non-nucleoside inhibitors.

31 March 2020

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Membrane association of the RNA-dependent RNA polymerase is essential for hepatitis C virus RNA replication

31 March 2020

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Biological evaluation of hepatitis C virus helicase inhibitors

31 March 2020

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Construction, expression, and characterization of a novel fully activated recombinant single-chain hepatitis C virus protease

31 March 2020

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Multiple full-length NS3 molecules are required for optimal unwinding of oligonucleotide DNA in vitro

31 March 2020

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The nonstructural protein 3 protease/helicase requires an intact protease domain to unwind duplex RNA efficiently

31 March 2020

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Hepatitis C virus NS3 RNA helicase activity is modulated by the two domains of NS3 and NS4A.

31 March 2020

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Modulation of hepatitis C virus NS3 protease and helicase activities through the interaction with NS4A

31 March 2020

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A kinetic analysis of the oligonucleotide-modulated ATPase activity of the helicase domain of the NS3 protein from hepatitis C virus. The first cycle of interaction of ATP with the enzyme is unique

31 March 2020

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Inhibition of the hepatitis C virus helicase-associated ATPase activity by the combination of ADP, NaF, MgCl2, and poly(rU). Two ADP binding sites on the enzyme-nucleic acid complex

31 March 2020

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Product release is the major contributor to kcat for the hepatitis C virus helicase-catalyzed strand separation of short duplex DNA.

31 March 2020

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ATP binding modulates the nucleic acid affinity of hepatitis C virus helicase

31 March 2020

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Periodic cycles of RNA unwinding and pausing by hepatitis C virus NS3 helicase

31 March 2020

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Nucleotide triphosphatase/helicase of hepatitis C virus as a target for antiviral therapy

31 March 2020

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Electrostatic analysis of the hepatitis C virus NS3 helicase reveals both active and allosteric site locations

31 March 2020

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Two novel conserved motifs in the hepatitis C virus NS3 protein critical for helicase action

31 March 2020

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Inhibition of Hepatitis C Virus Nonstructural Protein, Helicase Activity, and Viral Replication by a Recombinant Human Antibody Clone

31 March 2020

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Abrogation of hepatitis C virus NS3 helicase enzymatic activity by recombinant human antibodies

31 March 2020

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Isolation of specific and high-affinity RNA aptamers against NS3 helicase domain of hepatitis C virus

31 March 2020

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In vitro selection of RNA aptamers against the HCV NS3 helicase domain

31 March 2020

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Expression and purification of a hepatitis C virus NS3/4A complex, and characterization of its helicase activity with the Scintillation Proximity Assay system

31 March 2020

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Direct fluorometric measurement of hepatitis C virus helicase activity

31 March 2020

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An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus

31 March 2020

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Short-term antiviral efficacy of BILN 2061, a hepatitis C virus serine protease inhibitor, in hepatitis C genotype 1 patients.

31 March 2020

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Synthesis and evaluation of ATP-binding site directed potential inhibitors of nucleoside triphosphatases/helicases and polymerases of hepatitis C and other selected Flaviviridae viruses.

31 March 2020

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Hepatitis C virus NS3 ATPase/helicase: an ATP switch regulates the cooperativity among the different substrate binding sites

31 March 2020

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Double-stranded DNA-induced localized unfolding of HCV NS3 helicase subdomain 2.

31 March 2020

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Angiotensin-converting enzyme inhibitors

31 March 2020

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Potent inhibition of NTPase/helicase of the West Nile Virus by ring-expanded ("fat") nucleoside analogues

31 March 2020

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Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus

31 March 2020

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12 December 2020

Enzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells by using the herpes simplex virus amplicon system

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12 December 2020

Development of a Hepatitis C Virus RNA Helicase High Throughput Assay

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12 December 2020

Mutational analysis of the hepatitis C virus RNA helicase

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12 December 2020

2 references

12 December 2020

7 January 2021

inferred from DOI database lookup

Viral RNA replication in association with cellular membranes.

1 reference

12 December 2020

Polynucleotide modulation of the protease, nucleoside triphosphatase, and helicase activities of a hepatitis C virus NS3-NS4A complex isolated from transfected COS cells

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12 December 2020

ATP-binding domain of NTPase/helicase as a target for hepatitis C antiviral therapy.

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12 December 2020

Strategies for antiviral drug discovery

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12 December 2020

Virus-encoded RNA helicases

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12 December 2020

Inhibition of herpes simplex virus replication by a 2-amino thiazole via interactions with the helicase component of the UL5-UL8-UL52 complex

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12 December 2020

Helicase, a target for novel inhibitors of hepatitis C virus.

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12 December 2020

Structure-based mutagenesis study of hepatitis C virus NS3 helicase

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12 December 2020

Structure and function of hepatitis C virus NS3 helicase

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12 December 2020

Identifiers

DOI

10.1038/NRD1853

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13 August 2017

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