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TIGIT predominantly regulates the immune response via regulatory T cells.
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1 reference
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Europe PubMed Central
PMC publication ID
4639980
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26413872%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 February 2020
retracted paper
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retrieved
21 July 2024
reference URL
https://doi.org/10.1172/JCI183278
https://retractionwatch.com/?s=%22Mark+Smyth%22
title
TIGIT predominantly regulates the immune response via regulatory T cells
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
4639980
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26413872%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 February 2020
author
Nicole Joller
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
4639980
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26413872%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 February 2020
Michele W.L. Teng
series ordinal
6
1 reference
stated in
Europe PubMed Central
PMC publication ID
4639980
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26413872%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 February 2020
Mark J. Smyth
series ordinal
7
1 reference
stated in
Europe PubMed Central
PMC publication ID
4639980
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26413872%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 February 2020
Vijay Kuchroo
series ordinal
8
object named as
Vijay K Kuchroo
1 reference
stated in
Europe PubMed Central
PMC publication ID
4639980
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26413872%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 February 2020
Ana C. Anderson
series ordinal
9
object named as
Ana C Anderson
1 reference
stated in
Europe PubMed Central
PMC publication ID
4639980
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26413872%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 February 2020
author name string
Sema Kurtulus
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
4639980
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26413872%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 February 2020
Kaori Sakuishi
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
4639980
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26413872%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 February 2020
Shin-Foong Ngiow
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
4639980
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26413872%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 February 2020
Dewar J Tan
series ordinal
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
4639980
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26413872%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 February 2020
language of work or name
English
0 references
publication date
28 September 2015
1 reference
stated in
Europe PubMed Central
PMC publication ID
4639980
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26413872%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 February 2020
published in
Journal of Clinical Investigation
1 reference
stated in
Europe PubMed Central
PMC publication ID
4639980
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26413872%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 February 2020
volume
125
1 reference
stated in
Europe PubMed Central
PMC publication ID
4639980
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26413872%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 February 2020
issue
11
1 reference
stated in
Europe PubMed Central
PMC publication ID
4639980
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26413872%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 February 2020
page(s)
4053-4062
1 reference
stated in
Europe PubMed Central
PMC publication ID
4639980
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26413872%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 February 2020
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Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226.
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TIGIT and PD-1 impair tumor antigen-specific CD8⁺ T cells in melanoma patients
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Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer
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The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function
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Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection
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30 September 2017
T-cell immunoglobulin and ITIM domain (TIGIT) receptor/poliovirus receptor (PVR) ligand engagement suppresses interferon-γ production of natural killer cells via β-arrestin 2-mediated negative signaling
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Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction
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30 September 2017
Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639980
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Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies
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30 September 2017
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma
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30 September 2017
TIM3(+)FOXP3(+) regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer
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30 September 2017
Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection.
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T cell exhaustion
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30 September 2017
Vstm3 is a member of the CD28 family and an important modulator of T-cell function
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30 September 2017
Cutting edge: TIGIT has T cell-intrinsic inhibitory functions
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639980
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30 September 2017
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
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30 September 2017
The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639980
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30 September 2017
Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
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30 September 2017
Expression of adhesion molecules and ligands for activating and costimulatory receptors involved in cell-mediated cytotoxicity in a large panel of human melanoma cell lines
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30 September 2017
A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC
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30 September 2017
Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer
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30 September 2017
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.
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30 September 2017
DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors
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30 September 2017
The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639980
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30 September 2017
CTLA-4 control over Foxp3+ regulatory T cell function
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639980
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30 September 2017
The Foxp3+ regulatory T cell: a jack of all trades, master of regulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639980
retrieved
30 September 2017
LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systems
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639980
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30 September 2017
Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: an update on implications for chronic infections and tumor evasion
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639980
retrieved
30 September 2017
Interleukin-10 determines viral clearance or persistence in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639980
retrieved
30 September 2017
Resolution of a chronic viral infection after interleukin-10 receptor blockade
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639980
retrieved
30 September 2017
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639980
retrieved
30 September 2017
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639980
retrieved
30 September 2017
Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639980
retrieved
30 September 2017
Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639980
retrieved
30 September 2017
Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639980
retrieved
22 September 2018
Canonical Wnt signaling negatively modulates regulatory T cell function.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639980
retrieved
22 September 2018
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639980
retrieved
22 September 2018
Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639980
retrieved
22 September 2018
Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26413872
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1172/JCI81187
1 reference
stated in
Europe PubMed Central
PMC publication ID
4639980
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26413872%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 February 2020
PMC publication ID
4639980
1 reference
stated in
Europe PubMed Central
PMC publication ID
4639980
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26413872%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 February 2020
PubMed publication ID
26413872
1 reference
stated in
Europe PubMed Central
PMC publication ID
4639980
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26413872%20AND%20SRC:MED&resulttype=core&format=json
retrieved
25 February 2020
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