(Q36167596)

12 August 2017

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title

The anaemia of cancer: death by a thousand cuts (English)

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12 August 2017

Jerry L Spivak

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12 August 2017

language of work or name

English

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publication date

1 July 2005

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12 August 2017

published in

Nature Reviews Cancer

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12 August 2017

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12 August 2017

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12 August 2017

page(s)

543-555

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12 August 2017

cites work

Cancer statistics, 2004

1 reference

31 March 2020

1 reference

Anemia in oncology practice: relation to diseases and their therapies

31 March 2020

1 reference

Prevalence and outcomes of anemia in cancer: a systematic review of the literature

31 March 2020

1 reference

Chemotherapy-induced anemia in adults: incidence and treatment

31 March 2020

1 reference

Anemia: not just an innocent bystander?

31 March 2020

1 reference

Anemia in HIV infection: clinical impact and evidence-based management strategies

31 March 2020

1 reference

Impact of hemoglobin level and use of recombinant erythropoietin on efficacy of preoperative chemoradiation therapy for squamous cell carcinoma of the oral cavity and oropharynx

31 March 2020

1 reference

31 March 2020

1 reference

The longitudinal relationship of hemoglobin, fatigue and quality of life in anemic cancer patients: results from five randomized clinical trials

31 March 2020

1 reference

Breast cancer trial with erythropoietin terminated unexpectedly

31 March 2020

1 reference

Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial

31 March 2020

1 reference

Heparan sulphate bound growth factors: a mechanism for stromal cell mediated haemopoiesis

31 March 2020

1 reference

Purification and characterization of hypoxia-inducible factor 1

31 March 2020

1 reference

Hypoxia--a key regulatory factor in tumour growth

31 March 2020

1 reference

Targeting HIF-1 for cancer therapy

31 March 2020

1 reference

Anemia induces accumulation of erythropoietin mRNA in the kidney and liver

31 March 2020

1 reference

Insulin-like growth factors decrease oxygen-regulated erythropoietin production by human hepatoma cells (Hep G2)

31 March 2020

1 reference

Induction of HIF-1alpha in response to hypoxia is instantaneous

31 March 2020

1 reference

Receptor-based model accounts for phlebotomy-induced changes in erythropoietin pharmacokinetics

31 March 2020

1 reference

Increased plasma viscosity as a reason for inappropriate erythropoietin formation

31 March 2020

1 reference

The blood in systemic disorders

31 March 2020

1 reference

Hemoglobin levels correlate with interleukin-6 levels in patients with advanced untreated epithelial ovarian cancer: role of inflammation in cancer-related anemia

31 March 2020

1 reference

Inhibition of erythropoietin production in vitro by human interferon gamma

31 March 2020

1 reference

Inhibition of erythropoietin gene expression signaling involves the transcription factors GATA-2 and NF-kappaB.

31 March 2020

1 reference

Inhibition of human erythroid colony-forming units by tumor necrosis factor requires beta interferon.

31 March 2020

1 reference

Enhanced serum levels of beta-2-microglobulin, neopterin, and interferon-gamma in patients treated with recombinant tumor necrosis factor-alpha

31 March 2020

1 reference

Interaction of IL-1 beta, IL-6 and tumour necrosis factor-alpha (TNF-alpha) in human T cells activated by murine antigens

31 March 2020

1 reference

The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

31 March 2020

1 reference

Iron deprivation increases erythropoietin production in vitro, in normal subjects and patients with malignancy

31 March 2020

1 reference

Decreased erythropoietin response in patients with the anemia of cancer

31 March 2020

1 reference

Use of epoetin in patients with cancer: evidence-based clinical practice guidelines of the American Society of Clinical Oncology and the American Society of Hematology

31 March 2020

1 reference

Epoetin alfa therapy increases hemoglobin levels and improves quality of life in patients with cancer-related anemia who are not receiving chemotherapy and patients with anemia who are receiving chemotherapy.

31 March 2020

1 reference

Mechanisms of abnormal erythropoiesis in malignancy

31 March 2020

1 reference

Structural design and molecular evolution of a cytokine receptor superfamily

31 March 2020

1 reference

Erythropoietin receptor activation by a ligand-induced conformation change

31 March 2020

1 reference

Erythropoietin retards DNA breakdown and prevents programmed death in erythroid progenitor cells

31 March 2020

1 reference

Signal transduction by receptors with tyrosine kinase activity

31 March 2020

1 reference

Stem cell factor: laboratory and clinical aspects

31 March 2020

1 reference

TRAIL regulates normal erythroid maturation through an ERK-dependent pathway

31 March 2020

1 reference

Btk is required for an efficient response to erythropoietin and for SCF-controlled protection against TRAIL in erythroid progenitors.

31 March 2020

1 reference

Cachectin/tumor necrosis factor-alpha alters red blood cell kinetics and induces anemia in vivo

31 March 2020

1 reference

Differentiation stage-specific activation of p38 mitogen-activated protein kinase isoforms in primary human erythroid cells

31 March 2020

1 reference

Caspase activation is required for terminal erythroid differentiation

31 March 2020

1 reference

A novel mechanism of cooperation between c-Kit and erythropoietin receptor. Stem cell factor induces the expression of Stat5 and erythropoietin receptor, resulting in efficient proliferation and survival by erythropoietin

31 March 2020

1 reference

Death receptors couple to both cell proliferation and apoptosis

31 March 2020

1 reference

The molecular mechanism of erythropoietin action

31 March 2020

1 reference

The limit of hemoglobin synthesis in hereditary hemolytic anemia; its relation to the excretion of bile pigment

31 March 2020

1 reference

ANEMIA IN MALIGNANT NEOPLASTIC DISEASE.

31 March 2020

1 reference

31 March 2020

1 reference

The anemia of chronic disease: spectrum of associated diseases in a series of unselected hospitalized patients

31 March 2020

1 reference

EVIDENCE FOR TUMOUR NECROSIS FACTOR/CACHECTIN PRODUCTION IN CANCER

31 March 2020

1 reference

In vitro proliferation and differentiation of erythroid progenitors from patients with myelodysplastic syndromes: evidence for Fas-dependent apoptosis.

31 March 2020

1 reference

Localization of Fas and Fas ligand in bone marrow cells demonstrating myelodysplasia

31 March 2020

1 reference

Evidence for a role of TNF-related apoptosis-inducing ligand (TRAIL) in the anemia of myelodysplastic syndromes

31 March 2020

1 reference

Tumor necrosis factor-alpha inhibits generation of glycophorin A+ cells by CD34+ cells

31 March 2020

1 reference

Inhibition of human erythroid colony-forming units by interleukin-1 is mediated by gamma interferon

31 March 2020

1 reference

Macrophages From Cancer Patients: Analysis of TRAIL, TRAIL Receptors, and Colon Tumor Cell Apoptosis

31 March 2020

1 reference

Negative regulation of erythroblast maturation by Fas-L(+)/TRAIL(+) highly malignant plasma cells: a major pathogenetic mechanism of anemia in multiple myeloma.

31 March 2020

1 reference

Fas-L up-regulation by highly malignant myeloma plasma cells: role in the pathogenesis of anemia and disease progression.

31 March 2020

1 reference

Current and emerging infectious risks of blood transfusions

31 March 2020

1 reference

Transmission of West Nile Virus through Blood Transfusion in the United States in 2002

31 March 2020

1 reference

Recombinant human erythropoietin in anemic patients with end-stage renal disease. Results of a phase III multicenter clinical trial

31 March 2020

1 reference

Cardiovascular effects of erythropoietin and anemia correction

31 March 2020

1 reference

Anti-erythropoietin antibodies and pure red cell aplasia

31 March 2020

1 reference

Tissue-specific regulation of erythropoietin production in the murine kidney, brain, and uterus

31 March 2020

1 reference

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

31 March 2020

1 reference

Erythropoietin therapy for acute stroke is both safe and beneficial

31 March 2020

1 reference

Oxygen status of malignant tumors: pathogenesis of hypoxia and significance for tumor therapy

31 March 2020

1 reference

Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation

31 March 2020

1 reference

Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer.

31 March 2020

1 reference

Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer

31 March 2020

1 reference

Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival

31 March 2020

1 reference

Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its potential role in cervical carcinogenesis and tumor progression

31 March 2020

1 reference

Immunohistochemical expression of erythropoietin and erythropoietin receptor in breast carcinoma

31 March 2020

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Erythropoietin stimulates proliferation of human renal carcinoma cells

31 March 2020

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Erythropoietin is involved in growth and angiogenesis in malignant tumours of female reproductive organs

31 March 2020

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Inhibition of erythropoietin signalling destroys xenografts of ovarian and uterine cancers in nude mice

31 March 2020

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Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

31 March 2020

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Severe anemia is associated with poor tumor oxygenation in head and neck squamous cell carcinomas

31 March 2020

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Impact of hemoglobin levels before and during concurrent chemoradiotherapy on the response of treatment in patients with cervical carcinoma

31 March 2020

1 reference

Anemia is associated with decreased local control of surgically treated squamous cell carcinomas of the glottic larynx

31 March 2020

1 reference

Blood hemoglobin level and treatment outcome of early breast cancer

31 March 2020

1 reference

Hemoglobin as an Independent Prognostic Factor in the Radiotherapy of Head and Neck Tumors

31 March 2020

1 reference

The importance of hemoglobin levels during radiotherapy for carcinoma of the cervix

31 March 2020

1 reference

Prognostic impact of hemoglobin levels on treatment outcome in patients with nasopharyngeal carcinoma treated with sequential chemoradiotherapy or radiotherapy alone

31 March 2020

1 reference

Prognostic value of hemoglobin concentrations in patients with advanced head and neck cancer treated with combined radio-chemotherapy and surgery

31 March 2020

1 reference

Effects of recombinant human erythropoietin on the antitumor effect of cisplatin in SCID mice bearing human ovarian cancer: A possible oxygen effect

31 March 2020

1 reference

Recombinant human erythropoietin increases the radiosensitivity of xenografted human tumours in anaemic nude mice

31 March 2020

1 reference

Recombinant human erythropoietin attenuates weight loss in a murine cancer cachexia model

31 March 2020

1 reference

Erythropoietin induces tumor regression and antitumor immune responses in murine myeloma models

31 March 2020

1 reference

Effects of epoetin alfa on hematologic parameters and quality of life in cancer patients receiving nonplatinum chemotherapy: results of a randomized, double-blind, placebo-controlled trial.

31 March 2020

1 reference

Erythropoietin to treat anaemia in patients with head and neck cancer

31 March 2020

1 reference

Erythropoietin to treat anaemia in patients with head and neck cancer

31 March 2020

1 reference

Erythropoietin to treat anaemia in patients with head and neck cancer

31 March 2020

1 reference

Erythropoietin to treat anaemia in patients with head and neck cancer

31 March 2020

1 reference

Effect of haemopoietic growth factors on cancer cell lines and their role in chemosensitivity

31 March 2020

1 reference

Congenital disorder of oxygen sensing: association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors

31 March 2020

1 reference

Erythropoietin treatment of anemia associated with multiple myeloma

31 March 2020

1 reference

Epoetin treatment of anemia associated with cancer therapy: a systematic review and meta-analysis of controlled clinical trials

31 March 2020

1 reference

Classifying human cancer by analysis of gene expression

31 March 2020

1 reference

Tumor necrosis factor, cancer and anticancer therapy.

31 March 2020

1 reference

31 March 2020

1 reference

Distinct signaling from stem cell factor and erythropoietin in HCD57 cells

31 March 2020

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Integrative signaling by minimal erythropoietin receptor forms and c-Kit

31 March 2020

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Stem cell factor enhances erythropoietin-mediated transactivation of signal transducer and activator of transcription 5 (STAT5) via the PKA/CREB pathway

31 March 2020

1 reference

Stem cell factor protects c-kit+ human primary erythroid cells from apoptosis

31 March 2020

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Functional and biochemical consequences of abrogating the activation of multiple diverse early signaling pathways in Kit. Role for Src kinase pathway in Kit-induced cooperation with erythropoietin receptor

31 March 2020

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Steel factor sustains SCL expression and the survival of purified CD34+ bone marrow cells in the absence of detectable cell differentiation

31 March 2020

1 reference

Mitogen-activated protein kinase mediates erythropoietin-induced phosphorylation of the TAL1/SCL transcription factor in murine proerythroblasts

31 March 2020

1 reference

Stem cell factor and erythropoietin inhibit apoptosis of human erythroid progenitor cells through different signalling pathways

31 March 2020

1 reference

Stem cell factor increases the expression of FLIP that inhibits IFNgamma -induced apoptosis in human erythroid progenitor cells

31 March 2020

1 reference

Growth factor withdrawal from primary human erythroid progenitors induces apoptosis through a pathway involving glycogen synthase kinase-3 and Bax.

31 March 2020

1 reference

Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1

31 March 2020

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Severe iron deficiency anemia in transgenic mice expressing liver hepcidin

31 March 2020

1 reference

IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

31 March 2020

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Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease

31 March 2020

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Anemia of inflammation: the cytokine-hepcidin link

31 March 2020

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Effects of desferrioxamine therapy on chronic disease anemia associated with rheumatoid arthritis

31 March 2020

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Multicenter study of recombinant human erythropoietin in correction of anemia in rheumatoid arthritis

31 March 2020

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Activation of phosphatidylinositol 3-kinase is important for erythropoietin-induced erythropoiesis from CD34(+) hematopoietic progenitor cells

31 March 2020

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Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation.

31 March 2020

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Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors

31 March 2020

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Protein kinase C alpha controls erythropoietin receptor signaling

31 March 2020

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Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts

31 March 2020

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Raf-1 antagonizes erythroid differentiation by restraining caspase activation

31 March 2020

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Activation of the Akt/FKHRL1 pathway mediates the antiapoptotic effects of erythropoietin in primary human erythroid progenitors

31 March 2020

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FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity

31 March 2020

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Control of erythroid cell production via caspase-mediated cleavage of transcription factor SCL/Tal-1.

31 March 2020

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Correlation between neopterin, interferon-gamma and haemoglobin in patients with haematological disorders

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Comparison of serum and cell-specific cytokines in humans

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inferred from DOI database lookup

7 January 2021

based on heuristic

Stroma-derived factor 1alpha induces a selective inhibition of human erythroid development via the functional upregulation of Fas/CD95 ligand

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRC1648

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12 August 2017

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