(Q36143432)

English

CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime].

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Europe PubMed Central

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12 August 2017

CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime]. (English)

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Europe PubMed Central

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12 August 2017

Darryl C Zeldin

11

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Darryl C Zeldin

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12 August 2017

author name string

Michael Zhuo Wang

1

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12 August 2017

Janelle Y Saulter

2

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12 August 2017

Etsuko Usuki

3

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12 August 2017

Yen-Ling Cheung

4

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12 August 2017

Michael Hall

5

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12 August 2017

Arlene S Bridges

6

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12 August 2017

Greg Loewen

7

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12 August 2017

Oliver T Parkinson

8

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12 August 2017

Chad E Stephens

9

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Europe PubMed Central

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12 August 2017

James L Allen

10

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12 August 2017

David W Boykin

12

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Europe PubMed Central

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12 August 2017

Richard R Tidwell

13

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Europe PubMed Central

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12 August 2017

Andrew Parkinson

14

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Europe PubMed Central

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12 August 2017

Mary F Paine

15

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12 August 2017

James Edwin Hall

16

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12 August 2017

publication date

22 September 2006

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12 August 2017

Drug Metabolism and Disposition

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12 August 2017

34

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12 August 2017

12

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12 August 2017

1985-1994

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Europe PubMed Central

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12 August 2017

Efficacy of DB289 in Thai patients with Plasmodium vivax or acute, uncomplicated Plasmodium falciparum infections

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

2 October 2017

Regulation and inhibition of arachidonic acid omega-hydroxylases and 20-HETE formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

2 October 2017

Enhancement of cardiac L-type Ca2+ currents in transgenic mice with cardiac-specific overexpression of CYP2J2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

2 October 2017

Role of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids in hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

2 October 2017

DB-289 Immtech International

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

2 October 2017

Prostaglandin and leukotriene omega-hydroxylases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

2 October 2017

Alternative splicing determines the function of CYP4F3 by switching substrate specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

2 October 2017

HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

2 October 2017

A novel human cytochrome P450 4F isoform (CYP4F11): cDNA cloning, expression, and genomic structural characterization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

2 October 2017

In vitro-in vivo scaling of CYP kinetic data not consistent with the classical Michaelis-Menten model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

2 October 2017

Gene expression of a novel cytochrome P450 of the CYP4F subfamily in human seminal vesicles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

2 October 2017

P450 subfamily CYP2J and their role in the bioactivation of arachidonic acid in extrahepatic tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

2 October 2017

Role of human CYP4F2 in hepatic catabolism of the proinflammatory agent leukotriene B4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

2 October 2017

Anti-Pneumocystis activities of aromatic diamidoxime prodrugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

2 October 2017

Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

2 October 2017

Structure-activity studies of dicationically substituted bis-benzimidazoles against Giardia lamblia: correlation of antigiardial activity with DNA binding affinity and giardial topoisomerase II inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

2 October 2017

Structure-activity relationships of analogs of pentamidine against Plasmodium falciparum and Leishmania mexicana amazonensis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

2 October 2017

Synthesis and antiprotozoal activity of 2,5-bis(4-guanylphenyl)furans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

2 October 2017

Tumor-specific expression of cytochrome P450 CYP1B1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

2 July 2018

Leishmania donovani, Plasmodium berghei, Trypanosoma rhodesiense: antiprotozoal effects of some amidine types

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

2 July 2018

Pharmacokinetics and metabolism of the prodrug DB289 (2,5-bis[4-(N-methoxyamidino)phenyl]furan monomaleate) in rat and monkey and its conversion to the antiprotozoal/antifungal drug DB75 (2,5-bis(4-guanylphenyl)furan dihydrochloride).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

23 September 2018

Unusual dehydroxylation of antimicrobial amidoxime prodrugs by cytochrome b5 and NADH cytochrome b5 reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

23 September 2018

Metabolites of an orally active antimicrobial prodrug, 2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime, identified by liquid chromatography/tandem mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

23 September 2018

Monoclonal Antibodies to Cytochromes P450

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

23 September 2018

The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

23 September 2018

Enhanced permeability of the antimicrobial agent 2,5-bis(4-amidinophenyl)furan across Caco-2 cell monolayers via its methylamidoidme prodrug

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

23 September 2018

Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

23 September 2018

A novel cytochrome P450 enzyme responsible for the metabolism of ebastine in monkey small intestine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

23 September 2018

An inhibitory monoclonal antibody to human cytochrome P450 that specifically binds and inhibits P4502C9II, an allelic variant of P4502C9 having a single amino acid change Arg144 Cys.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

23 September 2018

Effects of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P450 fatty acid omega-hydroxylase, on renal function in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077835

21 October 2018

Development of pentamidine analogues as new agents for the treatment of Pneumocystis carinii pneumonia

1 reference

https://pubmed.ncbi.nlm.nih.gov/16997912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450-derived arachidonic acid metabolism in the rat kidney: characterization of selective inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16997912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P-450 1A1 expression in human small bowel: interindividual variation and inhibition by ketoconazole

1 reference

https://pubmed.ncbi.nlm.nih.gov/16997912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunolocalization of CYP1B1 in normal, human, fetal and adult eyes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16997912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of cytochrome P-450 4 enzymes in the kidney and liver: regulation by PPAR and species-difference between rat and human

1 reference

https://pubmed.ncbi.nlm.nih.gov/16997912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/DMD.106.010587

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

ResearchGate publication ID

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