(Q36026757)

11 August 2017

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title

The search for the retinoblastoma cell of origin (English)

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11 August 2017

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Michael A Dyer

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11 August 2017

Rod Bremner

series ordinal

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11 August 2017

language of work or name

English

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publication date

1 February 2005

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11 August 2017

published in

Nature Reviews Cancer

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11 August 2017

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11 August 2017

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11 August 2017

page(s)

91-101

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A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

11 August 2017

cites work

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Hedgehog and patched in neural development and disease

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The cells and molecules that make a cerebellum.

21 January 2018

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Retinal ganglion cell-derived sonic hedgehog signaling is required for optic disc and stalk neuroepithelial cell development

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Molecular insight into medulloblastoma and central nervous system primitive neuroectodermal tumor biology from hereditary syndromes: a review

21 January 2018

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Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma

21 January 2018

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Cell type-specific effects of Rb deletion in the murine retina.

21 January 2018

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Retinoblastoma: the disease, gene and protein provide critical leads to understand cancer.

21 January 2018

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Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

21 January 2018

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Mouse models of childhood cancer of the nervous system

21 January 2018

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The retinoblastoma tumour suppressor in development and cancer

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p107 and p130: versatile proteins with interesting pockets

21 January 2018

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Effects of an Rb mutation in the mouse

21 January 2018

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Requirement for a functional Rb-1 gene in murine development

21 January 2018

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Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

21 January 2018

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p107 is a suppressor of retinoblastoma development in pRb-deficient mice

21 January 2018

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Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

21 January 2018

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Regulating proliferation during retinal development

21 January 2018

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Vertebrate neural cell-fate determination: lessons from the retina

21 January 2018

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Mechanisms of loss of heterozygosity in retinoblastoma

21 January 2018

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Molecular basis of low-penetrance retinoblastoma

21 January 2018

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Rb regulates proliferation and rod photoreceptor development in the mouse retina

21 January 2018

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Cell differentiation in the retina of the mouse

21 January 2018

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Cell fate determination in the vertebrate retina

21 January 2018

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Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina

21 January 2018

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Genomic analysis of mouse retinal development

21 January 2018

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Comprehensive analysis of photoreceptor gene expression and the identification of candidate retinal disease genes

21 January 2018

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MicroSAGE is highly representative and reproducible but reveals major differences in gene expression among samples obtained from similar tissues

21 January 2018

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Retinoblastoma. Cell of origin.

21 January 2018

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Retinoblastoma tumor suppressor and genome stability

21 January 2018

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Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control.

21 January 2018

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Genetic analysis of the homeodomain transcription factor Chx10 in the retina using a novel multifunctional BAC transgenic mouse reporter

21 January 2018

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Developmental expression of a novel murine homeobox gene (Chx10): evidence for roles in determination of the neuroretina and inner nuclear layer

21 January 2018

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Pax6 is required for the multipotent state of retinal progenitor cells

21 January 2018

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Crx, a novel otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation.

21 January 2018

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Mutation and cancer: statistical study of retinoblastoma

21 January 2018

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Genetic origin of mutations predisposing to retinoblastoma

21 January 2018

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Comparative genomic hybridization of 49 primary retinoblastoma tumors identifies chromosomal regions associated with histopathology, progression, and patient outcome.

21 January 2018

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A Transgenic Mouse Model for Trilateral Retinoblastoma

21 January 2018

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Retinoblastoma in transgenic mice

21 January 2018

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Developmental defects in Rb-deficient retinae

21 January 2018

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The age distribution of cancer and a multi-stage theory of carcinogenesis

21 January 2018

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How many mutations are required for tumorigenesis? Implications from human cancer data

21 January 2018

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21 January 2018

The Hallmarks of Cancer

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Cell-autonomous and non-cell-autonomous functions of the Rb tumor suppressor in developing central nervous system

21 January 2018

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Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system

21 January 2018

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Extra-embryonic function of Rb is essential for embryonic development and viability

21 January 2018

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Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development

21 January 2018

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E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis.

21 January 2018

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Rb and p107 are required for normal cerebellar development and granule cell survival but not for Purkinje cell persistence

21 January 2018

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The orientation of cell division influences cell-fate choice in the developing mammalian retina

21 January 2018

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Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation

21 January 2018

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Dlx1, Dlx2, Pax6, Brn3b, and Chx10 homeobox gene expression defines the retinal ganglion and inner nuclear layers of the developing and adult mouse retina

21 January 2018

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The Ath5 proneural genes function upstream of Brn3 POU domain transcription factor genes to promote retinal ganglion cell development

21 January 2018

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Induction of different genetic changes by different classes of chemical carcinogens during progression of mouse skin tumors

21 January 2018

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Late retinal progenitor cells show intrinsic limitations in the production of cell types and the kinetics of opsin synthesis

31 March 2020

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p27Kip1 and p57Kip2 regulate proliferation in distinct retinal progenitor cell populations.

31 March 2020

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Marked differences in unilateral isolated retinoblastomas from young and older children studied by comparative genomic hybridization

31 March 2020

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Detection of chromosome imbalances in retinoblastoma by parallel karyotype and CGH analyses

31 March 2020

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The major cell populations of the mouse retina.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1545

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11 August 2017

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