(Q36085601)

12 August 2017

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title

IAPs, RINGs and ubiquitylation (English)

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12 August 2017

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John Silke

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David L Vaux

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1 April 2005

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Nature Reviews Molecular Cell Biology

12 August 2017

published in

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12 August 2017

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12 August 2017

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12 August 2017

page(s)

287-297

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Genetic control of programmed cell death in Drosophila

12 August 2017

cites work

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The head involution defective gene of Drosophila melanogaster functions in programmed cell death

21 January 2018

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grim, a novel cell death gene in Drosophila

21 January 2018

1 reference

Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells.

21 January 2018

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In vivo half-life of a protein is a function of its amino-terminal residue

21 January 2018

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Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat

21 January 2018

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Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function

31 March 2020

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The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

31 March 2020

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The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1

31 March 2020

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RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

31 March 2020

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The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID.

31 March 2020

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The role of ARK in stress-induced apoptosis in Drosophila cells

31 March 2020

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Down-regulation of DIAP1 triggers a novel Drosophila cell death pathway mediated by Dark and DRONC.

31 March 2020

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Unrestrained caspase-dependent cell death caused by loss of Diap1 function requires the Drosophila Apaf-1 homolog, Dark

31 March 2020

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The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated, processed form of the apical caspase DRONC.

31 March 2020

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A cloning method to identify caspases and their regulators in yeast: identification of Drosophila IAP1 as an inhibitor of the Drosophila caspase DCP-1.

31 March 2020

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The Drosophila caspase DRONC is regulated by DIAP1

31 March 2020

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Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors

31 March 2020

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A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors

31 March 2020

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X-linked IAP is a direct inhibitor of cell-death proteases

31 March 2020

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Characterization of XIAP-deficient mice

31 March 2020

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IAP proteins: blocking the road to death's door

31 March 2020

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Drosophila sickle is a novel grim-reaper cell death activator

31 March 2020

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The damage-responsive Drosophila gene sickle encodes a novel IAP binding protein similar to but distinct from reaper, grim, and hid.

31 March 2020

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sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein

31 March 2020

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Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

31 March 2020

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

31 March 2020

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A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

31 March 2020

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Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

31 March 2020

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The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

31 March 2020

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HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

31 March 2020

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The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein

31 March 2020

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A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

31 March 2020

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NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP

31 March 2020

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Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP.

31 March 2020

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XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs.

31 March 2020

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Mechanisms underlying ubiquitination

31 March 2020

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Proteolysis and the cell cycle: with this RING I do thee destroy

31 March 2020

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Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis

31 March 2020

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Morgue mediates apoptosis in the Drosophila melanogaster retina by promoting degradation of DIAP1.

31 March 2020

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A conserved RING finger protein required for histone H2B monoubiquitination and cell size control.

31 March 2020

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Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter

31 March 2020

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Ubiquitin signalling: what's in a chain?

31 March 2020

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A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.

31 March 2020

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The U box is a modified RING finger — a common domain in ubiquitination

31 March 2020

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Structural insights into the U-box, a domain associated with multi-ubiquitination

31 March 2020

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U-box proteins as a new family of ubiquitin ligases

31 March 2020

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Structure and biochemical function of a prototypical Arabidopsis U-box domain

31 March 2020

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Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

31 March 2020

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Human mdm2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization

31 March 2020

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The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis

31 March 2020

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Dissection of DIAP1 functional domains via a mutant replacement strategy.

31 March 2020

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IAP-antagonists exhibit non-redundant modes of action through differential DIAP1 binding

31 March 2020

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Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms

31 March 2020

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Reaper eliminates IAP proteins through stimulated IAP degradation and generalized translational inhibition

31 March 2020

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Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.

31 March 2020

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Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO

31 March 2020

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Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells

31 March 2020

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Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3

31 March 2020

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Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation

31 March 2020

1 reference

Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex

31 March 2020

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The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

31 March 2020

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Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair

31 March 2020

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

31 March 2020

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Jafrac2 is an IAP antagonist that promotes cell death by liberating Dronc from DIAP1

31 March 2020

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Reaper is regulated by IAP-mediated ubiquitination.

31 March 2020

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A novel ubiquitin fusion system bypasses the mitochondria and generates biologically active Smac/DIABLO

31 March 2020

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Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro

31 March 2020

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Neutralization of Smac/Diablo by inhibitors of apoptosis (IAPs). A caspase-independent mechanism for apoptotic inhibition

31 March 2020

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Unlike Diablo/smac, Grim promotes global ubiquitination and specific degradation of X chromosome-linked inhibitor of apoptosis (XIAP) and neither cause apoptosis

31 March 2020

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Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins

31 March 2020

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Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase

31 March 2020

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Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function

31 March 2020

1 reference

Drosophila Bruce can potently suppress Rpr- and Grim-dependent but not Hid-dependent cell death

31 March 2020

1 reference

Smac3, a Novel Smac/DIABLO Splicing Variant, Attenuates the Stability and Apoptosis-inhibiting Activity of X-linked Inhibitor of Apoptosis Protein

31 March 2020

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IAP degradation: decisive blow or altruistic sacrifice?

31 March 2020

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Substrate cleavage by caspases generates protein fragments with Smac/Diablo-like activities

31 March 2020

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HtrA2/Omi, a sheep in wolf's clothing

31 March 2020

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Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination

31 March 2020

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Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim

31 March 2020

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Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways.

31 March 2020

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Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

31 March 2020

1 reference

Identification of a new copper metabolism gene by positional cloning in a purebred dog population

31 March 2020

1 reference

The copper toxicosis gene product Murr1 directly interacts with the Wilson disease protein

31 March 2020

1 reference

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

31 March 2020

1 reference

A novel role for XIAP in copper homeostasis through regulation of MURR1

31 March 2020

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TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival

31 March 2020

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Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice

31 March 2020

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TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells

31 March 2020

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CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival

31 March 2020

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Regulation of TRAF2 signaling by self-induced degradation.

31 March 2020

1 reference

TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2

31 March 2020

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Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila

31 March 2020

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Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation

31 March 2020

1 reference

Receptor interacting protein is ubiquitinated by cellular inhibitor of apoptosis proteins (c-IAP1 and c-IAP2) in vitro

31 March 2020

1 reference

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

31 March 2020

1 reference

Mass spectrometric analysis of tumor necrosis factor receptor-associated factor 1 ubiquitination mediated by cellular inhibitor of apoptosis 2.

31 March 2020

1 reference

The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF

31 March 2020

1 reference

A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha

31 March 2020

1 reference

The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites

31 March 2020

1 reference

Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

31 March 2020

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Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

31 March 2020

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The ubiquitin-protein ligase E6-associated protein (E6-AP) serves as its own substrate

31 March 2020

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Control of human PIRH2 protein stability: involvement of TIP60 and the proteosome

31 March 2020

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Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

31 March 2020

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Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

31 March 2020

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HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.

31 March 2020

1 reference

Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2.

31 March 2020

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The ubiquitin ligase COP1 is a critical negative regulator of p53

31 March 2020

1 reference

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

31 March 2020

1 reference

Caspases, IAPs and Smac/DIABLO: mechanisms from structural biology

31 March 2020

1 reference

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

31 March 2020

1 reference

An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRM1621

1 reference

12 August 2017

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