(Q36081460)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640233%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

title

A phase I trial of bryostatin 1 in patients with advanced malignancy using a 24 hour intravenous infusion (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640233%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

main subject

phase I clinical trial

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640233%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640233%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640233%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

D Crowther

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640233%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

J Prendiville

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640233%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

A T McGown

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640233%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

C Scheid

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640233%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

R Young

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640233%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

J Chang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640233%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

S Owens

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640233%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

language of work or name

English

0 references

publication date

1 August 1995

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640233%20AND%20SRC:MED&resulttype=core&format=json

British Journal of Cancer

22 October 2019

published in

1 reference

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22 October 2019

volume

1 reference

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22 October 2019

issue

1 reference

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22 October 2019

page(s)

461-468

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640233%20AND%20SRC:MED&resulttype=core&format=json

A phase I study of intravenous bryostatin 1 in patients with advanced cancer

22 October 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033979

Phase I study of bryostatin 1: assessment of interleukin 6 and tumor necrosis factor alpha induction in vivo. The Cancer Research Campaign Phase I Committee

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033979

Protein kinase C--a question of specificity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033979

Cytokine-mediated protein kinase C activation is a signal for lineage determination in bipotential granulocyte macrophage colony-forming cells.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033979

Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033979

Bryostatin, an activator of the calcium phospholipid-dependent protein kinase, blocks phorbol ester-induced differentiation of human promyelocytic leukemia cells HL-60.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033979

Antineoplastic bryostatins are multipotential stimulators of human hematopoietic progenitor cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033979

Effects of activators of protein kinase C, including bryostatins 1 and 2, on the growth of A549 human lung carcinoma cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033979

The action of bryostatin on normal human hematopoietic progenitors is mediated by accessory cell release of growth factors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033979

Phorbol ester and bryostatin effects on growth and the expression of oestrogen responsive and TGF-beta 1 genes in breast tumour cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033979

In vivo administration of the anticancer agent bryostatin 1 activates platelets and neutrophils and modulates protein kinase C activity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033979

Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033979

Bryostatin, a non-phorbol macrocyclic lactone, activates intact human polymorphonuclear leukocytes and binds to the phorbol ester receptor

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033979

Varied differentiation responses of human leukemias to bryostatin 1.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033979

Involvement of protein kinase C in phorbol ester-induced sensitization of HeLa cells to cis-diamminedichloroplatinum(II).

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033979

Bryostatin 1, a unique biologic response modifier: anti-leukemic activity in vitro.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033979

Effect of pharmacologic manipulation of protein kinase C by phorbol dibutyrate and bryostatin 1 on the clonogenic response of human granulocyte-macrophage progenitors to recombinant GM-CSF.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033979

Successful treatment of murine melanoma with bryostatin 1.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033979

Differential effects of bryostatin 1 and phorbol ester on human breast cancer cell lines.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033979

Activation and growth of murine tumor-specific T-cells which have in vivo activity with bryostatin 1

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033979

Preclinical evaluation of bryostatin as an anticancer agent against several murine tumor cell lines: in vitro versus in vivo activity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033979

Towards selective pharmacological modulation of protein kinase C--opportunities for the development of novel antineoplastic agents

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033979

The effects of the macrocyclic lactone bryostatin-1 on leukemic cells in vitro

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033979

A peroxidase-linked enzyme immunoassay for tumour necrosis factor alpha utilising alternative colorimetric or chemilumimetric substrates

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033979

Bryostatin 1-induced hairy cell features on chronic lymphocytic leukemia cells in vitro.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033979

Antiproliferative properties of phorbol ester tumour promoters

23 September 2018

1 reference

12 December 2020

A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone

1 reference

12 December 2020

Comparative effects of polymyxin B, phorbol ester and bryostatin on protein phosphorylation, protein kinase C translocation, phospholipid metabolism and differentiation of HL60 cells

1 reference

12 December 2020

Inhibition by bryostatin 1 of the phorbol ester-induced blockage of differentiation in hexamethylene bisacetamide-treated Friend erythroleukemia cells

1 reference

12 December 2020

Bryostatin induces changes in protein kinase C location and activity without altering c-myc gene expression in human promyelocytic leukemia cells (HL-60)

1 reference

12 December 2020

Phosphorylation of lamin B at the nuclear membrane by activated protein kinase C

1 reference

12 December 2020

Bryostatin 1 activates protein kinase C and induces monocytic differentiation of HL-60 cells

1 reference

12 December 2020

Mimicry of bryostatin 1 induced phosphorylation patterns in HL-60 cells by high-phorbol ester concentrations

1 reference

12 December 2020

Regulation of hematopoiesis-IV: The role of interleukin-3 and bryostatin 1 in the growth of erythropoietic progenitors from normal and anemic W/Wv mice

1 reference

12 December 2020

Differentiation of HL-60 cells is associated with an increase in the 35-kDa protein lipocortin I

1 reference

12 December 2020

Successful treatment of human Waldenström's macroglobulinemia with combination biological and chemotherapy agents

1 reference

12 December 2020

The role of protein kinase C isoenzymes in the growth inhibition caused by bryostatin 1 in human A549 lung and MCF-7 breast carcinoma cells

1 reference

12 December 2020

Expression of proto-oncogene c-jun during differentiation of B-chronic lymphocytic leukemia

1 reference

12 December 2020

Inhibition of phorbol ester-induced T cell proliferation by bryostatin is associated with rapid degradation of protein kinase C

1 reference

12 December 2020

Identifiers

DOI

10.1038/BJC.1995.356

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640233%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640233%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

PubMed publication ID

7640233

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640233%20AND%20SRC:MED&resulttype=core&format=json