(Q35936438)

11 August 2017

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title

Functional genomics to new drug targets (English)

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11 August 2017

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Richard Kramer

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11 August 2017

Dalia Cohen

series ordinal

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11 August 2017

publication date

1 November 2004

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Nature Reviews Drug Discovery

11 August 2017

published in

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11 August 2017

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11 August 2017

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11 August 2017

page(s)

965-972

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Basic local alignment search tool

11 August 2017

cites work

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Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

21 January 2018

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What is the value added by human intervention in protein structure prediction?

21 January 2018

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Identification of common molecular subsequences

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Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils

21 January 2018

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A Genomic Perspective on Protein Families

21 January 2018

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The Sequence of the Human Genome

21 January 2018

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Distinctive gene expression patterns in human mammary epithelial cells and breast cancers

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Molecular classification of cancer: class discovery and class prediction by gene expression monitoring

21 January 2018

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Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

21 January 2018

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Prediction of central nervous system embryonal tumour outcome based on gene expression

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Systematic variation in gene expression patterns in human cancer cell lines

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A gene expression database for the molecular pharmacology of cancer

21 January 2018

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Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex

21 January 2018

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Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia

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Microarray analysis of gene expression in the prefrontal cortex in schizophrenia: a preliminary study

21 January 2018

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Gene expression profile for schizophrenia: discrete neuron transcription patterns in the entorhinal cortex

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Activity-based probes for the proteomic profiling of metalloproteases

21 January 2018

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Quantitative analysis of complex protein mixtures using isotope-coded affinity tags

21 January 2018

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Recent advancements in surface-enhanced laser desorption/ionization-time of flight-mass spectrometry

21 January 2018

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Use of proteomic patterns in serum to identify ovarian cancer

21 January 2018

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Self-assembling protein microarrays

21 January 2018

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Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors

21 January 2018

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Functional organization of the yeast proteome by systematic analysis of protein complexes

21 January 2018

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Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

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A map of the interactome network of the metazoan C. elegans

21 January 2018

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A protein interaction map of Drosophila melanogaster

21 January 2018

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Functional proteomics mapping of a human signaling pathway

21 January 2018

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A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway

21 January 2018

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Specific inhibition of the rat ligand-gated ion channel P2X3 function via methoxyethoxy-modified phosphorothioated antisense oligonucleotides

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Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

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Bactericidal antisense effects of peptide-PNA conjugates.

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A potent and specific morpholino antisense inhibitor of hepatitis C translation in mice

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Cellular response to an antisense-mediated shift of Bcl-x pre-mRNA splicing and antineoplastic agents

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Peptide nucleic acids are potent modulators of endogenous pre-mRNA splicing of the murine interleukin-5 receptor-alpha chain

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Unravelling the general properties of siRNAs: strength in numbers and lessons from the past

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Isoform-specific knockdown and expression of adaptor protein ShcA using small interfering RNA.

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A system for stable expression of short interfering RNAs in mammalian cells

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A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

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Inhibition of CD40-mediated endothelial cell activation with antisense oligonucleotides

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ICAM-1 and VCAM-1 antisense oligonucleotides attenuate in vivo leucocyte adherence and inflammation in rat inflammatory bowel disease

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Independent combinatorial effect of antisense oligonucleotides and RNAi-mediated specific inhibition of the recombinant rat P2X3 receptor

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siRNA relieves chronic neuropathic pain

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Effects of A‐317491, a novel and selective P2X3/P2X2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration

21 January 2018

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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

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Arrayed adenoviral expression libraries for functional screening

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Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways

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TIP, a T-cell factor identified using high-throughput screening increases survival in a graft-versus-host disease model

21 January 2018

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An integrated functional genomics screening program reveals a role for BMP-9 in glucose homeostasis

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Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells

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Genome-scale functional profiling of the mammalian AP-1 signaling pathway

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A resource for large-scale RNA-interference-based screens in mammals.

21 January 2018

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A large-scale RNAi screen in human cells identifies new components of the p53 pathway

21 January 2018

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Zebrafish: a new model on the pharmaceutical catwalk

21 January 2018

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Drugs that induce repolarization abnormalities cause bradycardia in zebrafish

21 January 2018

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The impact of drug-induced QT interval prolongation on drug discovery and development

21 January 2018

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Dissection of angiogenic signaling in zebrafish using a chemical genetic approach

21 January 2018

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Genetic analysis of digestive physiology using fluorescent phospholipid reporters.

21 January 2018

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Behavioral screening for cocaine sensitivity in mutagenized zebrafish

21 January 2018

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Acute effects of alcohol on larval zebrafish: a genetic system for large-scale screening

21 January 2018

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Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation

21 January 2018

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A model for studying Alzheimer's Abeta42-induced toxicity in Drosophila melanogaster

21 January 2018

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Rapid and sensitive sequence comparison with FASTP and FASTA

21 January 2018

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Yellow pages to the transcriptome

31 March 2020

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Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

31 March 2020

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Gene expression correlates of clinical prostate cancer behavior

31 March 2020

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Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia.

31 March 2020

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Difference gel electrophoresis: a single gel method for detecting changes in protein extracts

31 March 2020

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A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p

31 March 2020

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Functional downregulation of P2X3 receptor subunit in rat sensory neurons reveals a significant role in chronic neuropathic and inflammatory pain.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD1552

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Dimensions Publication ID

11 August 2017

1041972515

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