(Q35876589)

10 August 2017

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title

The HIF pathway as a therapeutic target (English)

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10 August 2017

author

Christopher J. Schofield

series ordinal

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10 August 2017

Kirsty S Hewitson

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10 August 2017

publication date

1 August 2004

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10 August 2017

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10 August 2017

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10 August 2017

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10 August 2017

page(s)

704-711

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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

10 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

From erythropoietin to oxygen: hypoxia-inducible factor hydroxylases and the hypoxia signal pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Modulating the hypoxia-inducible factor signaling pathway: applications from cardiovascular disease to cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Characterization and comparative analysis of the EGLN gene family

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

The von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Hypoxia-inducible factor and its biomedical relevance

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Direct intramuscular gene transfer of naked DNA encoding vascular endothelial growth factor augments collateral development and tissue perfusion

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Salvage angiogenesis induced by adenovirus-mediated gene transfer of vascular endothelial growth factor protects against ischemic vascular occlusion

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Biologic bypass with the use of adenovirus-mediated gene transfer of the complementary deoxyribonucleic acid for vascular endothelial growth factor 121 improves myocardial perfusion and function in the ischemic porcine heart

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Intramyocardial injection of naked DNA encoding HIF-1alpha/VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

PR39, a peptide regulator of angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Non-heme iron oxygenases

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Dioxygen activation at mononuclear nonheme iron active sites: enzymes, models, and intermediates

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2β

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Nickel requires hypoxia-inducible factor-1 alpha, not redox signaling, to induce plasminogen activator inhibitor-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analogue N-oxaloglycine and its derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Prolyl 4-hydroxylases and their protein disulfide isomerase subunit

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Activation of the hypoxia‐inducible factor pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

The antimycotic ciclopirox olamine induces HIF-1alpha stability, VEGF expression, and angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

The selectivity and inhibition of AlkB.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

Suppression of tumor growth through disruption of hypoxia-inducible transcription

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903202-7

7 January 2021

10.1016/S1359-6446(04)03202-7

Identifiers

DOI

1 reference

10 August 2017

1 reference