(Q35720021)

25822023

9 August 2017

title

CCN1 induces hepatic ductular reaction through integrin αvβ₅-mediated activation of NF-κB. (English)

1 reference

9 August 2017

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25822023%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Ki-Hyun Kim

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25822023%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Chih-Chiun Chen

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25822023%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Gianfranco Alpini

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25822023%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

language of work or name

English

0 references

publication date

30 March 2015

1 reference

Journal of Clinical Investigation

9 August 2017

1 reference

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25822023%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

volume

125

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25822023%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25822023%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

page(s)

1886-1900

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25822023%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

7 June 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4463205/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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27 July 2018

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27 July 2018

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27 July 2018

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Matricellular protein CCN1/CYR61: a new player in inflammation and leukocyte trafficking

27 July 2018

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27 July 2018

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27 July 2018

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Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts.

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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Yes-associated protein regulates the hepatic response after bile duct ligation

27 July 2018

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Cilengitide: a prototypic integrin inhibitor for the treatment of glioblastoma and other malignancies

27 July 2018

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27 July 2018

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NF-κB inhibition delays DNA damage-induced senescence and aging in mice

27 July 2018

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Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets

27 July 2018

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27 July 2018

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Ductular reactions in human liver: diversity at the interface

27 July 2018

1 reference

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Low-Dose Lipopolysaccharide Affects Lung Allergic Responses by Regulating Jagged1 Expression on Antigen-Pulsed Dendritic Cells

27 July 2018

1 reference

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Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential

27 July 2018

1 reference

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Retro-orbital injections in mice.

27 July 2018

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Human hepatic stem cell and maturational liver lineage biology.

27 July 2018

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Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin

27 July 2018

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Cellular senescence controls fibrosis in wound healing

27 July 2018

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The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

27 July 2018

1 reference

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Matricellular protein CCN1 activates a proinflammatory genetic program in murine macrophages

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

Recent advances in the regulation of cholangiocyte proliferation and function during extrahepatic cholestasis

27 July 2018

1 reference

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Morphological and functional heterogeneity of the mouse intrahepatic biliary epithelium

27 July 2018

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CYR61 and alphaVbeta5 integrin cooperate to promote invasion and metastasis of tumors growing in preirradiated stroma.

27 July 2018

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IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver

27 July 2018

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Notch signaling regulates bile duct morphogenesis in mice

27 July 2018

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Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver

27 July 2018

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Role of alphavbeta6 integrin in acute biliary fibrosis

27 July 2018

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Isolation, culture and immortalisation of hepatic oval cells from adult mice fed a choline-deficient, ethionine-supplemented diet

27 July 2018

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A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis

27 July 2018

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Cytotoxicity of TNFalpha is regulated by integrin-mediated matrix signaling

27 July 2018

1 reference

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Notch signalling: a simple pathway becomes complex

27 July 2018

1 reference

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NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway

27 July 2018

1 reference

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The cholangiopathies: disorders of biliary epithelia

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

Targeted mutagenesis of the angiogenic protein CCN1 (CYR61). Selective inactivation of integrin alpha6beta1-heparan sulfate proteoglycan coreceptor-mediated cellular functions

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

Identification of a novel integrin alphavbeta3 binding site in CCN1 (CYR61) critical for pro-angiogenic activities in vascular endothelial cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

Soluble form of Jagged1: unique product of epithelial keratinocytes and a regulator of keratinocyte differentiation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

CYR61 (CCN1) is essential for placental development and vascular integrity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

NF-kappaB is activated in cholestasis and functions to reduce liver injury

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

Heterogeneity of the proliferative capacity of rat cholangiocytes after bile duct ligation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

Ludwig symposium on biliary disorders--part I. Pathogenesis of ductal plate abnormalities

27 July 2018

1 reference

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Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

Mutations in the human Jagged1 gene are responsible for Alagille syndrome

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

Biliary physiology in rats with bile ductular cell hyperplasia. Evidence for a secretory function of proliferated bile ductules

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

Expression of cyr61, a growth factor-inducible immediate-early gene

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-β signaling.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

Mouse Sertoli cells sustain de novo generation of regulatory T cells by triggering the notch pathway through soluble JAGGED1.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

Role of stem cell factor and granulocyte colony-stimulating factor in remodeling during liver regeneration

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

CCN1/CYR61: the very model of a modern matricellular protein.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

Liver-specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

Wnt/beta-catenin signaling in murine hepatic transit amplifying progenitor cells.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

Remarkable heterogeneity displayed by oval cells in rat and mouse models of stem cell-mediated liver regeneration.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

Liver progenitor cells develop cholangiocyte-type epithelial polarity in three-dimensional culture

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

The matricellular protein CCN1 is essential for cardiac development

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

Isolation and culture of hepatic stellate cells

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

Evaluation of differential gene expression by microarray analysis in small and large cholangiocytes isolated from normal mice

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

Signalling pathways of the TNF superfamily: a double-edged sword

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463205

Morphological, molecular, and functional heterogeneity of cholangiocytes from normal rat liver

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25822023

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI79327

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25822023%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25822023%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

25822023

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25822023%20AND%20SRC:MED&resulttype=core&format=json