(Q35709088)

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Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1

scientific article published on 9 January 2012

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20 January 2020

Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1 (English)

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20 January 2020

James L. Manley

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20 January 2020

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20 January 2020

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Masaki Magari

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20 January 2020

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Kagefumi Todo

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20 January 2020

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Yuichi Kanehiro

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Yuichi Kanehiro

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20 January 2020

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Misaki Negishi

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20 January 2020

Junji Fukuoka

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20 January 2020

Wenjian Gan

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20 January 2020

Takuya Hikasa

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20 January 2020

Yoshiaki Kaga

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20 January 2020

Masayuki Takemoto

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20 January 2020

Xialu Li

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20 January 2020

Hitoshi Ohmori

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20 January 2020

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9 January 2012

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20 January 2020

Proceedings of the National Academy of Sciences of the United States of America

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20 January 2020

109

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20 January 2020

4

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20 January 2020

1216-1221

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20 January 2020

R-loop-mediated genomic instability is caused by impairment of replication fork progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

14-3-3 adaptor proteins recruit AID to 5'-AGCT-3'-rich switch regions for class switch recombination.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

GANP-mediated recruitment of activation-induced cytidine deaminase to cell nuclei and to immunoglobulin variable region DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

Enhancement of hypermutation frequency in the chicken B cell line DT40 for efficient diversification of the antibody repertoire

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

SR proteins in vertical integration of gene expression from transcription to RNA processing to translation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

Balancing AID and DNA repair during somatic hypermutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

The SR protein family of splicing factors: master regulators of gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

Activation-induced cytidine deaminase-mediated hypermutation in the DT40 cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

The biochemistry of somatic hypermutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

Genetic manipulation of an exogenous non-immunoglobulin protein by gene conversion machinery in a chicken B cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

MDM2 can interact with the C-terminus of AID but it is inessential for antibody diversification in DT40 B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

The double-edged sword of activation-induced cytidine deaminase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

Replication protein A interacts with AID to promote deamination of somatic hypermutation targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

AID is essential for immunoglobulin V gene conversion in a cultured B cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

Functional domains of the human splicing factor ASF/SF2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

Germinal centers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

Transcriptional activation by tetracyclines in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

Light chain gene conversion continues at high rate in an ALV-induced cell line.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

Ongoing diversification of the rearranged immunoglobulin light-chain gene in a bursal lymphoma cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

Primary structure of the human splicing factor asf reveals similarities with drosophila regulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

ASF alternative transcripts are highly conserved between mouse and man

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

27 July 2018

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1120368109

21 January 2018

Molecular mechanisms of antibody somatic hypermutation.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1120368109

21 January 2018

Two levels of protection for the B cell genome during somatic hypermutation.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1120368109

21 January 2018

Separate domains of AID are required for somatic hypermutation and class-switch recombination

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1120368109

21 January 2018

The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1120368109

21 January 2018

Transcription-coupled events associating with immunoglobulin switch region chromatin

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1120368109

21 January 2018

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1120368109

21 January 2018

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1120368109

21 January 2018

Reversible switching of immunoglobulin hypermutation machinery in a chicken B cell line.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1120368109

21 January 2018

AID is required for c-myc/IgH chromosome translocations in vivo

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1120368109

21 January 2018

Somatic hypermutation in the heavy chain locus correlates with transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268305

25 September 2018

Somatic hypermutation of immunoglobulin genes is linked to transcription initiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22232677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1073/PNAS.1120368109

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22232677%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

2012PNAS..109.1216K

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Europe PubMed Central

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20 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22232677%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

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