(Q35743118)

10 August 2017

1 reference

title

Mitogen-activated protein kinases in apoptosis regulation (English)

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10 August 2017

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Josef M Penninger

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Teiji Wada

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10 August 2017

language of work or name

English

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publication date

1 April 2004

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10 August 2017

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10 August 2017

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10 August 2017

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10 August 2017

page(s)

2838-2849

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ERK7 is an autoactivated member of the MAPK family

10 August 2017

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Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1

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JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells

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Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis

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ASK1 mediates apoptotic cell death induced by genotoxic stress.

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The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

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Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

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7 January 2021

The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product

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Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

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Signal transduction by the JNK group of MAP kinases

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MAPK pathways in radiation responses

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JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

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Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

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Activation of the p38 mitogen-activated protein kinase pathway arrests cell cycle progression and differentiation of immature thymocytes in vivo

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JNK is required for effector T-cell function but not for T-cell activation

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7 January 2021

Defective T Cell Differentiation in the Absence of Jnk1

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7 January 2021

Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53

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7 January 2021

Isolation of MEK5 and differential expression of alternatively spliced forms

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7 January 2021

Blocked Ras activation in anergic CD4+ T cells

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7 January 2021

SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis

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7 January 2021

MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha

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7 January 2021

Transcription factor ATF2 regulation by the JNK signal transduction pathway

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7 January 2021

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

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7 January 2021

A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

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7 January 2021

The Hallmarks of Cancer

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7 January 2021

c-Jun is essential for normal mouse development and hepatogenesis

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7 January 2021

The Ras-Raf-MEK-ERK pathway in the treatment of cancer

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7 January 2021

MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous.

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7 January 2021

Cytoskeleton reorganization induces the urokinase-type plasminogen activator gene via the Ras/extracellular signal-regulated kinase (ERK) signaling pathway

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7 January 2021

Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

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7 January 2021

Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death

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7 January 2021

ERK 1,2 and p38 pathways are involved in the proliferative stimuli mediated by urokinase in osteoblastic SaOS-2 cell line

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7 January 2021

Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus

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7 January 2021

Cell cycle and apoptosis: common pathways to life and death.

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7 January 2021

Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells.

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7 January 2021

Activation of extracellular signal-regulated kinase by ultraviolet is mediated through Src-dependent epidermal growth factor receptor phosphorylation. Its implication in an anti-apoptotic function

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7 January 2021

The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development

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7 January 2021

A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf

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7 January 2021

Signaling pathways activated by daunorubicin

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7 January 2021

Primary Structure of BMK1: A New Mammalian MAP Kinase

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7 January 2021

BetaPix-enhanced p38 activation by Cdc42/Rac/PAK/MKK3/6-mediated pathway. Implication in the regulation of membrane ruffling

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7 January 2021

Activation of the JNK signaling pathway: breaking the brake on apoptosis

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7 January 2021

Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C

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7 January 2021

Tyrosine kinases and gastric cancer

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7 January 2021

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4+ T Cells

1 reference

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7 January 2021

Involvement of JNK-mediated pathway in EGF-mediated protection against paclitaxel-induced apoptosis in SiHa human cervical cancer cells.

1 reference

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7 January 2021

ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons

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7 January 2021

Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

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7 January 2021

Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77.

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7 January 2021

Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases

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7 January 2021

Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207556

7 January 2021

Identification of c-Jun NH2-terminal Protein Kinase (JNK)-activating Kinase 2 as an Activator of JNK but Not p38

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7 January 2021

Neuronal activity-dependent cell survival mediated by transcription factor MEF2

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7 January 2021

Calcineurin enhances MEF2 DNA binding activity in calcium-dependent survival of cerebellar granule neurons

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7 January 2021

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

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7 January 2021

Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1.

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7 January 2021

Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3

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7 January 2021

MEF2: a calcium-dependent regulator of cell division, differentiation and death

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7 January 2021

MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion

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7 January 2021

Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK

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7 January 2021

c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases

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7 January 2021

Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3

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7 January 2021

Stress induces mitochondria-mediated apoptosis independent of SAPK/JNK activation in embryonic stem cells.

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7 January 2021

Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation

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7 January 2021

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G 1

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7 January 2021

Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

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7 January 2021

Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition

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7 January 2021

ERK5 and ERK2 cooperate to regulate NF-kappaB and cell transformation

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7 January 2021

Map kinase signaling pathways and hematologic malignancies

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7 January 2021

P38 alpha mitogen-activated protein kinase sensitizes cells to apoptosis induced by different stimuli.

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7 January 2021

Activation of Jun Kinase/Stress-activated Protein Kinase by GTPase-deficient Mutants of Gα12 and Gα13

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7 January 2021

Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

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7 January 2021

Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects

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7 January 2021

A tyrosine kinase profile of prostate carcinoma

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7 January 2021

Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development

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7 January 2021

c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation

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7 January 2021

The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy.

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7 January 2021

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

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7 January 2021

mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK.

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7 January 2021

The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells.

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7 January 2021

Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation

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7 January 2021

Development of anticancer drugs targeting the MAP kinase pathway

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7 January 2021

c-Jun NH2-terminal kinase-mediated activation of interleukin-1beta converting enzyme/CED-3-like protease during anticancer drug-induced apoptosis

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7 January 2021

The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest

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7 January 2021

ERK5 MAPK regulates embryonic angiogenesis and acts as a hypoxia-sensitive repressor of vascular endothelial growth factor expression

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7 January 2021

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.

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7 January 2021

JNK is involved in signal integration during costimulation of T lymphocytes.

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7 January 2021

Mitogen-activated protein kinase cascades and regulation of gene expression

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7 January 2021

Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults

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7 January 2021

SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development

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7 January 2021

Roles of MAPKKK ASK1 in stress-induced cell death.

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7 January 2021

Activation of the protein kinase p38 in the spindle assembly checkpoint and mitotic arrest.

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7 January 2021

Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis

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7 January 2021

The stress-activated protein kinase pathways

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7 January 2021

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

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7 January 2021

Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase

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7 January 2021

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207556

7 January 2021

Impaired synergistic activation of stress-activated protein kinase SAPK/JNK in mouse embryonic stem cells lacking SEK1/MKK4: different contribution of SEK2/MKK7 isoforms to the synergistic activation

1 reference

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7 January 2021

Mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 deficiency protects brain from ischemic injury in mice

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7 January 2021

Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207556

7 January 2021

Identification of mitogen-activated protein kinase kinase as a chemoresistant pathway in MCF-7 cells by using gene expression microarray

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207556

7 January 2021

Signaling life and death in the thymus: timing is everything

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207556

7 January 2021

Ceramide activates the stress-activated protein kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207556

7 January 2021

A mammalian scaffold complex that selectively mediates MAP kinase activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207556

7 January 2021

T cell inactivation linked to Ras block

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207556

7 January 2021

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207556

7 January 2021

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207556

7 January 2021

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207556

7 January 2021

Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207556

7 January 2021

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207556

7 January 2021

Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207556

7 January 2021

p38 mitogen-activated protein kinase pathway promotes skeletal muscle differentiation. Participation of the Mef2c transcription factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207556

7 January 2021

Regulation of fas ligand expression during activation-induced cell death in T cells by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207556

7 January 2021

Components of a new human protein kinase signal transduction pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207556

7 January 2021

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1128/MCB.19.12.8469

Identifiers

DOI

10.1038/SJ.ONC.1207556

1 reference

10 August 2017

1 reference