(Q35618780)

9 August 2017

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title

Part I: Hodgkin's lymphoma--molecular biology of Hodgkin and Reed-Sternberg cells (English)

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9 August 2017

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Roman K Thomas

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9 August 2017

Daniel Re

series ordinal

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9 August 2017

Jürgen Wolf

series ordinal

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9 August 2017

Volker Diehl

series ordinal

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9 August 2017

language of work or name

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1 January 2004

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Lancet Oncology Commission

9 August 2017

published in

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9 August 2017

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9 August 2017

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9 August 2017

page(s)

11-18

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Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development

9 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Rare occurrence of classical Hodgkin's disease as a T cell lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Origin of Nodular Lymphocyte-Predominant Hodgkin's Disease from a Clonal Expansion of Highly Mutated Germinal-Center B Cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Clonal selection and learning in the antibody system

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

FLICE-inhibitory protein is a key regulator of germinal center B cell apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Cutting edge: cellular Fas-associated death domain-like IL-1-converting enzyme-inhibitory protein protects germinal center B cells from apoptosis during germinal center reactions

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Defective octamer-dependent transcription is responsible for silenced immunoglobulin transcription in Reed-Sternberg cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Deregulation of immunoglobulin gene transcription in the Hodgkin-Reed Sternberg cell line L1236.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Down-regulation of BOB.1/OBF.1 and Oct2 in classical Hodgkin disease but not in lymphocyte predominant Hodgkin disease correlates with immunoglobulin transcription

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

The transcription factor PU.1, necessary for B-cell development is expressed in lymphocyte predominance, but not classical Hodgkin's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Loss of the B-lineage-specific gene expression program in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Evidence that Hodgkin and Reed-Sternberg cells in Hodgkin disease do not represent cell fusions

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Cultivated H-RS cells are resistant to CD95L-mediated apoptosis despite expression of wild-type CD95.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Constitutive expression of c-FLIP in Hodgkin and Reed-Sternberg cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Low frequency of FAS mutations in Reed-Sternberg cells of Hodgkin's lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

High expression of the CC chemokine TARC in Reed-Sternberg cells. A possible explanation for the characteristic T-cell infiltratein Hodgkin's lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Identification of Hodgkin and Reed-Sternberg cell-specific genes by gene expression profiling

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Loss of B cell identity correlates with loss of B cell-specific transcription factors in Hodgkin/Reed-Sternberg cells of classical Hodgkin lymphoma.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin's lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Recurrent involvement of the REL and BCL11A loci in classical Hodgkin lymphoma.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Ligand-independent signaling by overexpressed CD30 drives NF-kappaB activation in Hodgkin-Reed-Sternberg cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

STAT3 is constitutively activated in Hodgkin cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Interleukin 13 is secreted by and stimulates the growth of Hodgkin and Reed-Sternberg cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Concordance for Hodgkin's disease in identical twins suggesting genetic susceptibility to the young-adult form of the disease

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Hodgkin's disease and Epstein-Barr virus. Altered antibody pattern before diagnosis

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Expression of Epstein-Barr virus latent gene products in tumour cells of Hodgkin's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Epstein-Barr virus latent membrane protein expression in Hodgkin and Reed-Sternberg cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Detection of Epstein-Barr virus in Hodgkin-Reed-Sternberg cells : no evidence for the persistence of integrated viral fragments inLatent membrane protein-1 (LMP-1)-negative classical Hodgkin's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

The origin of CD95-gene mutations in B-cell lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Analysis of BCL-6 mutations in classic Hodgkin disease of the B- and T-cell type.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Lack of BCL10 mutations in Hodgkin's disease-derived cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Proficient mismatch repair protein expression in Hodgkin and Reed Sternberg cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Clonal loss of heterozygosity in microdissected Hodgkin and Reed-Sternberg cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Loss of heterozygosity in the Hodgkin-Reed Sternberg cell line L1236.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

MDM2 gene amplification and lack of p53 point mutations in Hodgkin and Reed-Sternberg cells: results from single-cell polymerase chain reaction and molecular cytogenetic studies

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901319-6

7 January 2021

10.1016/S1470-2045(03)01319-6

Identifiers

DOI

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9 August 2017

1 reference