(Q35694222)

9 August 2017

title

A fragmenting hybrid approach for targeted delivery of multiple therapeutic agents to the malaria parasite (English)

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9 August 2017

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9 August 2017

Matthew Bogyo

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9 August 2017

Sumit S Mahajan

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9 August 2017

Edgar Deu

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9 August 2017

Erica M W Lauterwasser

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9 August 2017

Melissa J Leyva

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9 August 2017

Jonathan A Ellman

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9 August 2017

publication date

24 January 2011

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9 August 2017

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9 August 2017

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9 August 2017

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9 August 2017

page(s)

415-419

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Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity

9 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265971

Functional studies of Plasmodium falciparum dipeptidyl aminopeptidase I using small molecule inhibitors and active site probes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265971

Artemisinin Resistance in Plasmodium falciparum Malaria

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265971

The global portfolio of new antimalarial medicines under development.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265971

Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265971

Relationship between antimalarial activity and heme alkylation for spiro- and dispiro-1,2,4-trioxolane antimalarials

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265971

Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265971

Hybrid molecules with a dual mode of action: dream or reality?

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265971

Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265971

Identification of an antimalarial synthetic trioxolane drug development candidate

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265971

Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265971

Tetrameric dipeptidyl peptidase I directs substrate specificity by use of the residual pro-part domain

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265971

On the molecular mechanism of chloroquine's antimalarial action

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3265971

Artemisinin-resistant malaria in Asia.

12 July 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100002

Dispiro-1,2,4-trioxane analogues of a prototype dispiro-1,2,4-trioxolane: mechanistic comparators for artemisinin in the context of reaction pathways with iron(II).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100002

Iron-mediated degradation kinetics of substituted dispiro-1,2,4-trioxolane antimalarials.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100002

Design and synthesis of endoperoxide antimalarial prodrug models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100002

Synthesis of tetrasubstituted ozonides by the Griesbaum coozonolysis reaction: diastereoselectivity and functional group transformations by post-ozonolysis reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100002

Kinetics of iron-mediated artemisinin degradation: effect of solvent composition and iron salt

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100002

Application of thiol-olefin co-oxygenation methodology to a new synthesis of the 1,2,4-trioxane pharmacophore

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21360816

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/CMDC.201100002

1 reference

9 August 2017

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9 August 2017

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