(Q35688217)

9 August 2017

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title

Recent advances in protein tyrosine phosphatase 1B inhibitors (English)

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9 August 2017

Scott D Taylor

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9 August 2017

Bryan Hill

series ordinal

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9 August 2017

language of work or name

English

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publication date

1 March 2004

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Expert Opinion on Investigational Drugs

9 August 2017

published in

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9 August 2017

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9 August 2017

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9 August 2017

page(s)

199-214

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Insulin signalling and the regulation of glucose and lipid metabolism

9 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Protein tyrosine phosphatase 1B: a novel target for type 2 diabetes and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Protein tyrosine phosphatase 1B interacts with the activated insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Dynamics of protein-tyrosine phosphatases in rat adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Protein-tyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Increased abundance of specific skeletal muscle protein-tyrosine phosphatases in a genetic model of insulin-resistant obesity and diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Skeletal muscle protein tyrosine phosphatase activity and tyrosine phosphatase 1B protein content are associated with insulin action and resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Abnormal Regulation of Protein Tyrosine Phosphatase Activities in Skeletal Muscle of Insulin-Resistant Humans

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.13.3.199

The ins and outs of leptin receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

PTP1B regulates leptin signal transduction in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Insulin receptor internalization and signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatase-1B.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Dynamics of the interaction between the insulin receptor and protein tyrosine-phosphatase 1B in living cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Crystal structure of human protein tyrosine phosphatase 1B

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

An overview of the protein tyrosine phosphatase superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Protein-tyrosine phosphatases: biological function, structural characteristics, and mechanism of catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Protein tyrosine phosphatase substrate specificity: size and phosphotyrosine positioning requirements in peptide substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Protein tyrosine phosphatase 1B inhibition: opportunities and challenges

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Inhibitors of protein tyrosine phosphatase 1B (PTP1B).

21 January 2018

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PTP1B inhibitors as potential therapeutics in the treatment of type 2 diabetes and obesity

21 January 2018

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Selecting protein tyrosine phosphatases as drug targets

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Protein tyrosine phosphatase 1B inhibitors for diabetes

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Protein tyrosine phosphatases: structure and function, substrate specificity, and inhibitor development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Protein tyrosine phosphatase 1B: a new target for the treatment of obesity and associated co-morbidities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Protein-tyrosine phosphatase 1B (PTP1B): a novel therapeutic target for type 2 diabetes mellitus, obesity and related states of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Protein tyrosine phosphatases: prospects for therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Phosphoryltyrosyl mimetics in the design of peptide-based signal transduction inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: A paradigm for inhibitor design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

The YRD motif is a major determinant of substrate and inhibitor specificity in T-cell protein-tyrosine phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Development of a robust scintillation proximity assay for protein tyrosine phosphatase 1B using the catalytically inactive (C215S) mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

The structure of PTP-1B in complex with a peptide inhibitor reveals an alternative binding mode for bisphosphonates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Acquisition of a specific and potent PTP1B inhibitor from a novel combinatorial library and screening procedure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Probing the molecular basis for potent and selective protein-tyrosine phosphatase 1B inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Structure-based design and discovery of novel inhibitors of protein tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

The Structural Basis for the Selectivity of Benzotriazole Inhibitors of PTP1B

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Structure determination of T cell protein-tyrosine phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Impaired Bone Marrow Microenvironment and Immune Function in T Cell Protein Tyrosine Phosphatase–deficient Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Discovery and Structure−Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Potent, selective inhibitors of protein tyrosine phosphatase 1B

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Discovery of a potent, selective protein tyrosine phosphatase 1B inhibitor using a linked-fragment strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Identification of a monoacid-Based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Steric hindrance as a basis for structure-based design of selective inhibitors of protein-tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Acylsulfonamide-containing PTP1B inhibitors designed to mimic an enzyme-bound water of hydration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3-d]thiophenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Synthesis and PTP1B inhibition of novel 4-aryl-1-oxa-9-thiacyclopenta[b]fluorenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Identification of a novel class of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Formylchromone derivatives as a novel class of protein tyrosine phosphatase 1B inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Synthesis and biological activity of a novel class of small molecular weight peptidomimetic competitive inhibitors of protein tyrosine phosphatase 1B

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Investigation of potential bioisosteric replacements for the carboxyl groups of peptidomimetic inhibitors of protein tyrosine phosphatase 1B: identification of a tetrazole-containing inhibitor with cellular activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Modification of the N-terminus of peptidomimetic protein tyrosine phosphatase 1B (PTP1B) inhibitors: identification of analogues with cellular activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Cellular effects of small molecule PTP1B inhibitors on insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

PTP1B antisense-treated mice show regulation of genes involved in lipogenesis in liver and fat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.3.199

10.1517/13543784.13.3.199

21 January 2018

Identifiers

DOI

1 reference

9 August 2017

1 reference