(Q35671281)

English

Oncogenic KRAS-induced epiregulin overexpression contributes to aggressive phenotype and is a promising therapeutic target in non-small-cell lung cancer

scientific article published on 10 September 2012

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Europe PubMed Central

PubMed publication ID

9 August 2017

Oncogenic KRAS-induced epiregulin overexpression contributes to aggressive phenotype and is a promising therapeutic target in non-small-cell lung cancer (English)

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Europe PubMed Central

PubMed publication ID

9 August 2017

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N Sunaga

1

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Europe PubMed Central

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9 August 2017

K Kaira

2

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9 August 2017

H Imai

3

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Europe PubMed Central

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9 August 2017

K Shimizu

4

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Europe PubMed Central

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9 August 2017

T Nakano

5

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Europe PubMed Central

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9 August 2017

D S Shames

6

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Europe PubMed Central

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9 August 2017

L Girard

7

1 reference

Europe PubMed Central

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9 August 2017

J Soh

8

1 reference

Europe PubMed Central

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9 August 2017

M Sato

9

1 reference

Europe PubMed Central

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9 August 2017

Y Iwasaki

10

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Europe PubMed Central

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9 August 2017

T Ishizuka

11

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Europe PubMed Central

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9 August 2017

A F Gazdar

12

1 reference

Europe PubMed Central

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9 August 2017

J D Minna

13

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9 August 2017

M Mori

14

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9 August 2017

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publication date

10 September 2012

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Europe PubMed Central

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9 August 2017

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Europe PubMed Central

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9 August 2017

32

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9 August 2017

34

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Europe PubMed Central

PubMed publication ID

9 August 2017

4034-4042

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Molecular biology of lung cancer: clinical implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451140

12 July 2018

Oncogenic KRAS‐induced interleukin‐8 overexpression promotes cell growth and migration and contributes to aggressive phenotypes of non‐small cell lung cancer

1 reference

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12 July 2018

Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy

1 reference

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12 July 2018

Global cancer statistics

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1 reference

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Clinicopathological and therapeutic significance of CXCL12 expression in lung cancer

1 reference

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12 July 2018

Biological and clinical significance of KRAS mutations in lung cancer: an oncogenic driver that contrasts with EGFR mutation

1 reference

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Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells

1 reference

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Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer

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Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors

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HER family receptor abnormalities in lung cancer brain metastases and corresponding primary tumors

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12 July 2018

Dual knockdown of N-ras and epiregulin synergistically suppressed the growth of human hepatoma cells

1 reference

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12 July 2018

Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines

1 reference

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12 July 2018

Intratumoral epiregulin is a marker of advanced disease in non-small cell lung cancer patients and confers invasive properties on EGFR-mutant cells

1 reference

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12 July 2018

Deregulated EGFR signaling during lung cancer progression: mutations, amplicons, and autocrine loops

1 reference

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12 July 2018

Profiling of transcripts and proteins modulated by K-ras oncogene in the lung tissues of K-ras transgenic mice by omics approaches.

1 reference

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12 July 2018

Genetic predictors of MEK dependence in non-small cell lung cancer

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12 July 2018

Somatic mutations affect key pathways in lung adenocarcinoma

1 reference

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12 July 2018

Epiregulin expression by Ets-1 and ERK signaling pathway in Ki-ras-transformed cells

1 reference

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12 July 2018

PIK3CA mutations and copy number gains in human lung cancers

1 reference

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12 July 2018

Epiregulin promotes migration and invasion of salivary adenoid cystic carcinoma cell line SACC-83 through activation of ERK and Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451140

12 July 2018

ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451140

12 July 2018

KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4451140

12 July 2018

Mediators of vascular remodelling co-opted for sequential steps in lung metastasis.

1 reference

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12 July 2018

KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib

1 reference

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12 July 2018

The role of RAS oncogene in survival of patients with lung cancer: a systematic review of the literature with meta-analysis

1 reference

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Profiling the evolution of human metastatic bladder cancer

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Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer

1 reference

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Epiregulin as a major autocrine/paracrine factor released from ERK- and p38MAPK-activated vascular smooth muscle cells

1 reference

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12 July 2018

Epiregulin is more potent than EGF or TGFalpha in promoting in vitro wound closure due to enhanced ERK/MAPK activation

1 reference

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Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling: activation of the epiregulin gene

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Involvement of deregulated epiregulin expression in tumorigenesis in vivo through activated Ki-Ras signaling pathway in human colon cancer cells.

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Activation of ErbB4 by the bifunctional epidermal growth factor family hormone epiregulin is regulated by ErbB2

1 reference

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Epiregulin is a potent pan-ErbB ligand that preferentially activates heterodimeric receptor complexes

1 reference

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1 reference

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NCI-Navy Medical Oncology Branch cell line data base

1 reference

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Epiregulin. A novel epidermal growth factor with mitogenic activity for rat primary hepatocytes

1 reference

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1 reference

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21 January 2018

Identifiers

10.1038/ONC.2012.402

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

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