Address
:
[go:
up one dir
,
main page
]
Include Form
Remove Scripts
Accept Cookies
Show Images
Show Referer
Rotate13
Base64
Strip Meta
Strip Title
Session Cookies
Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q35661987)
Watch
English
Molecular insights into regulation of JAK2 in myeloproliferative neoplasms
scientific article published on 30 March 2015
In more languages
default for all languages
No label defined
No description defined
edit
Statements
instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
4447858
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25824690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
review article
1 reference
stated in
Europe PubMed Central
title
Molecular insights into regulation of JAK2 in myeloproliferative neoplasms
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
4447858
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25824690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
author
Stevan R Hubbard
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
4447858
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25824690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
author name string
Olli Silvennoinen
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
4447858
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25824690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
language of work or name
English
0 references
publication date
30 March 2015
1 reference
stated in
Europe PubMed Central
PMC publication ID
4447858
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25824690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
published in
Blood
1 reference
stated in
Europe PubMed Central
PMC publication ID
4447858
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25824690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
volume
125
1 reference
stated in
Europe PubMed Central
PMC publication ID
4447858
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25824690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
issue
22
1 reference
stated in
Europe PubMed Central
PMC publication ID
4447858
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25824690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
page(s)
3388-3392
1 reference
stated in
Europe PubMed Central
PMC publication ID
4447858
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25824690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
cites work
ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
The molecular regulation of Janus kinase (JAK) activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
Mechanism of activation of protein kinase JAK2 by the growth hormone receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
Somatic mutations of calreticulin in myeloproliferative neoplasms
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
JAK/STAT signaling in hematological malignancies.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
Mouse models of myeloproliferative neoplasms: JAK of all grades
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
The constitutive activation of Jak2-V617F is mediated by a π stacking mechanism involving phenylalanines 595 and 617.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
JAK2 V617F constitutive activation requires JH2 residue F595: a pseudokinase domain target for specific inhibitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
Phosphorylation of Jak2 on Ser(523) inhibits Jak2-dependent leptin receptor signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
Phosphorylation of JAK2 at serine 523: a negative regulator of JAK2 that is stimulated by growth hormone and epidermal growth factor.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
A gain-of-function mutation of JAK2 in myeloproliferative disorders
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
Some speculations on the myeloproliferative syndromes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-alpha signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
Regulation of the Jak2 tyrosine kinase by its pseudokinase domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
The Jak-Stat pathway in normal and perturbed hematopoiesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
Jak2 is essential for signaling through a variety of cytokine receptors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
Structural and functional basis for JAK3-deficient severe combined immunodeficiency
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
An amino acid substitution in the Drosophila hopTum-l Jak kinase causes leukemia-like hematopoietic defects.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
12 July 2018
From Janus kinase 2 to calreticulin: the clinically relevant genomic landscape of myeloproliferative neoplasms
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
25 September 2018
Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
25 September 2018
Identifiers
DOI
10.1182/BLOOD-2015-01-621110
1 reference
stated in
Europe PubMed Central
PMC publication ID
4447858
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25824690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
PMC publication ID
4447858
1 reference
stated in
Europe PubMed Central
PMC publication ID
4447858
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25824690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
PubMed publication ID
25824690
1 reference
stated in
Europe PubMed Central
PMC publication ID
4447858
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25824690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
ResearchGate publication ID
274319428
0 references
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit