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English
CUP promotes deadenylation and inhibits decapping of mRNA targets.
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1 reference
stated in
Europe PubMed Central
PMC publication ID
3185967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21937713%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
title
CUP promotes deadenylation and inhibits decapping of mRNA targets
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3185967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21937713%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
author
Elisa Izaurralde
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
3185967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21937713%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
Cátia Igreja
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
3185967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21937713%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
author name string
Catia Igreja
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21937713
retrieved
7 August 2017
publication date
1 September 2011
1 reference
stated in
Europe PubMed Central
PMC publication ID
3185967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21937713%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
published in
Genes & Development
1 reference
stated in
Europe PubMed Central
PMC publication ID
3185967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21937713%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
volume
25
1 reference
stated in
Europe PubMed Central
PMC publication ID
3185967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21937713%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
issue
18
1 reference
stated in
Europe PubMed Central
PMC publication ID
3185967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21937713%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
page(s)
1955-1967
1 reference
stated in
Europe PubMed Central
PMC publication ID
3185967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21937713%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
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PubMed Central
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HPat provides a link between deadenylation and decapping in metazoa
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PubMed Central
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The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target release
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The control of mRNA decapping and P-body formation.
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12 July 2018
Deadenylation is a widespread effect of miRNA regulation
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Similar Modes of Interaction Enable Trailer Hitch and EDC3 To Associate with DCP1 and Me31B in Distinct Protein Complexes
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SMAUG is a major regulator of maternal mRNA destabilization in Drosophila and its translation is activated by the PAN GU kinase.
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A cup full of functions
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12 July 2018
Pathways for mRNA localization in the cytoplasm
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PubMed Central
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12 July 2018
Oskar allows nanos mRNA translation in Drosophila embryos by preventing its deadenylation by Smaug/CCR4.
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PubMed Central
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12 July 2018
mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes
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12 July 2018
Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles
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12 July 2018
Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements
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12 July 2018
Mechanisms of translational regulation in Drosophila
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12 July 2018
Regulation of cap-dependent translation by eIF4E inhibitory proteins
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12 July 2018
Cup is a nucleocytoplasmic shuttling protein that interacts with the eukaryotic translation initiation factor 4E to modulate Drosophila ovary development.
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12 July 2018
A complex containing the CCR4 and CAF1 proteins is involved in mRNA deadenylation in Drosophila
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12 July 2018
Cup is an eIF4E binding protein required for both the translational repression of oskar and the recruitment of Barentsz
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12 July 2018
Drosophila Cup is an eIF4E-binding protein that functions in Smaug-mediated translational repression
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12 July 2018
Control of poly(A) polymerase level is essential to cytoplasmic polyadenylation and early development in Drosophila
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12 July 2018
A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E
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PubMed Central
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12 July 2018
Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G
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12 July 2018
A novel inhibitor of cap-dependent translation initiation in yeast: p20 competes with eIF4G for binding to eIF4E.
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12 July 2018
Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E
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12 July 2018
Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential
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PubMed Central
reference URL
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12 July 2018
The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding Proteins
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12 July 2018
Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology
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12 July 2018
Smaug assembles an ATP-dependent stable complex repressing nanos mRNA translation at multiple levels.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185967
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26 September 2018
The translational repressor Cup associates with the adaptor protein Miranda and the mRNA carrier Staufen at multiple time-points during Drosophila oogenesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185967
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26 September 2018
Rapid ATP-dependent deadenylation of nanos mRNA in a cell-free system from Drosophila embryos
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185967
retrieved
26 September 2018
Efficient protein trafficking requires trailer hitch, a component of a ribonucleoprotein complex localized to the ER in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185967
retrieved
26 September 2018
An essential cytoplasmic function for the nuclear poly(A) binding protein, PABP2, in poly(A) tail length control and early development in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185967
retrieved
26 September 2018
Smaug recruits the CCR4/POP2/NOT deadenylase complex to trigger maternal transcript localization in the early Drosophila embryo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185967
retrieved
26 September 2018
Drosophila cup is an eIF4E binding protein that associates with Bruno and regulates oskar mRNA translation in oogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185967
retrieved
26 September 2018
Orb and a long poly(A) tail are required for efficient oskar translation at the posterior pole of the Drosophila oocyte
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185967
retrieved
26 September 2018
Nanos interacts with cup in the female germline of Drosophila.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185967
retrieved
26 September 2018
Translational regulation of oskar mRNA occurs independent of the cap and poly(A) tail in Drosophila ovarian extracts.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185967
retrieved
26 September 2018
The Drosophila CPEB homolog, orb, is required for oskar protein expression in oocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185967
retrieved
26 September 2018
The Drosophila gene fs(2)cup interacts with otu to define a cytoplasmic pathway required for the structure and function of germ-line chromosomes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185967
retrieved
26 September 2018
Identifiers
DOI
10.1101/GAD.17136311
1 reference
stated in
Europe PubMed Central
PMC publication ID
3185967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21937713%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
PMC publication ID
3185967
1 reference
stated in
Europe PubMed Central
PMC publication ID
3185967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21937713%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
PubMed publication ID
21937713
1 reference
stated in
Europe PubMed Central
PMC publication ID
3185967
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21937713%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
ResearchGate publication ID
51661455
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