(Q35139963)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12774240%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

review article

1 reference

title

Resistance mechanisms of gastrointestinal cancers: why does conventional chemotherapy fail? (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12774240%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12774240%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

P Rudolph

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12774240%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

G Kloeppel

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12774240%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

U R Foelsch

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12774240%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

publication date

28 May 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12774240%20AND%20SRC:MED&resulttype=core&format=json

International Journal of Colorectal Disease

4 November 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12774240%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

volume

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12774240%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

issue

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12774240%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

page(s)

470-480

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12774240%20AND%20SRC:MED&resulttype=core&format=json

Assessment of P-glycoprotein, glutathione-based detoxifying enzymes and O6-alkylguanine-DNA alkyltransferase as potential indicators of constitutive drug resistance in human colorectal tumors

4 November 2019

cites work

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12 December 2020

Src family kinase inhibitor PP2 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis

1 reference

12 December 2020

Deleted in Colorectal Cancer (DCC) encodes a netrin receptor

1 reference

12 December 2020

The dilemma of gastroenterological oncology: we know a lot but we still achieve too little

1 reference

12 December 2020

Thymidine phosphorylase and dihydropyrimidine dehydrogenase protein expression in colorectal cancer

1 reference

12 December 2020

Thymidylate synthase protein and p53 mRNA form an in vivo ribonucleoprotein complex

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12 December 2020

Gastrointestinal stromal tumors

1 reference

12 December 2020

Dihydropyrimidine dehydrogenase activity and mRNA expression in advanced gastric cancer analyzed in relation to effectiveness of preoperative 5-fluorouracil-based chemotherapy

1 reference

12 December 2020

Tumor cell invasion is promoted by activation of protease activated receptor-1 in cooperation with the alpha vbeta 5 integrin

1 reference

12 December 2020

Specific COX-2 inhibitors: prospects of therapy with new analgesic and anti-inflammatory substances

1 reference

12 December 2020

High expression of thymidylate synthase leads to resistance to 5-fluorouracil in biliary tract carcinoma in vitro

1 reference

12 December 2020

Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer.

1 reference

12 December 2020

New therapeutic options in colon cancer: focus on oxaliplatin

1 reference

12 December 2020

The Norton-Simon hypothesis revisited

1 reference

12 December 2020

Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome.

1 reference

12 December 2020

Cooperation between p53 and hMLH1 in a human colocarcinoma cell line in response to DNA damage

1 reference

12 December 2020

Capecitabine, an oral fluoropyrimidine carbamate with substantial activity in advanced colorectal cancer: results of a randomized phase II study

1 reference

12 December 2020

Chemoprevention of colorectal cancer

1 reference

12 December 2020

Methylation of the hMLH1 promoter but no hMLH1 mutations in sporadic gastric carcinomas with high-level microsatellite instability

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12 December 2020

Developments in fluoropyrimidine therapy for gastrointestinal cancer

1 reference

12 December 2020

The immunohistochemical marker Ki-S2: cell cycle kinetics and tissue distribution of a novel proliferation-specific antigen.

1 reference

12 December 2020

Gemcitabine: metabolism, mechanisms of action, and self-potentiation.

1 reference

12 December 2020

Cellular resistance mechanisms with impact on the therapy of multiple myeloma

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12 December 2020

Expression of intercellular adhesion molecule 1 (ICAM-1, CD54) in colonic epithelial cells

1 reference

12 December 2020

The role of the DNA mismatch repair system in the cytotoxicity of the topoisomerase inhibitors camptothecin and etoposide to human colorectal cancer cells.

1 reference

12 December 2020

SUMO-1 conjugation to intact DNA topoisomerase I amplifies cleavable complex formation induced by camptothecin

1 reference

12 December 2020

Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene.

1 reference

12 December 2020

Thrombin as a survival factor for cancer cells: thrombin activation in malignant effusions in vivo and inhibition of idarubicin-induced cell death in vitro

1 reference

12 December 2020

Cancer. p53, guardian of the genome

1 reference

12 December 2020

Association of time to recurrence with thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression in stage II and III colorectal cancer

1 reference

12 December 2020

Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells

1 reference

12 December 2020

Adhesion receptors in malignant transformation and dissemination of gastrointestinal tumors

1 reference

12 December 2020

DNA repair in resistance to alkylating anticancer drugs

1 reference

12 December 2020

Oral uracil and Ftorafur plus leucovorin: pharmacokinetics and toxicity in patients with metastatic cancer

1 reference

12 December 2020

Towards a better understanding of the cisplatin mode of action

1 reference

12 December 2020

The expression of multidrug resistance protein in human gastrointestinal tract carcinomas

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12 December 2020

P53 protein expression in gastric adenocarcinoma. Negative predictor of survival after postoperative adjuvant chemotherapy

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12 December 2020

A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate

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12 December 2020

Prevention of colon carcinogenesis by components of dietary fiber.

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12 December 2020

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12 December 2020

Resistance to cytotoxic drugs in DNA mismatch repair-deficient cells

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12 December 2020

5-Fluorouracil alters dihydrofolate reductase pre-mRNA splicing as determined by quantitative polymerase chain reaction

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12 December 2020

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12 December 2020

Clinical pharmacokinetics of capecitabine

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12 December 2020

Irinotecan plus fluorouracil/leucovorin for metastatic colorectal cancer: a new survival standard.

1 reference

12 December 2020

Culprit and victim -- DNA topoisomerase II.

1 reference

12 December 2020

Differential expression of protease-activated receptors-1 and -2 in stromal fibroblasts of normal, benign, and malignant human tissues

1 reference

12 December 2020

CD44s expression in human colon carcinomas influences growth of liver metastases

1 reference

12 December 2020

Quality of life during chemotherapy in patients with symptomatic advanced colorectal cancer. The Nordic Gastrointestinal Tumor Adjuvant Therapy Group.

1 reference

12 December 2020

Inhibition of epidermal growth factor receptor kinase induces protease-dependent apoptosis in human colon cancer cells☆☆☆

1 reference

12 December 2020

The tumor suppressor protein p53 stimulates the formation of the human topoisomerase I double cleavage complex in vitro

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12 December 2020

Mismatch repair proficiency and in vitro response to 5-fluorouracil

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12 December 2020

Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1.

1 reference

12 December 2020

Increased sensitivity to cisplatin in gastric cancer by antisense inhibition of the her-2/neu (c-erbB-2) gene

1 reference

12 December 2020

Systematic analysis of hMSH2 and hMLH1 in young colon cancer patients and controls

1 reference

12 December 2020

Stalking the guardian of the genome: p53 in colorectal carcinogenesis.

1 reference

12 December 2020

Apoptosis induced by overexpression of hMSH2 or hMLH1.

1 reference

12 December 2020

A genetic model for colorectal tumorigenesis

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12 December 2020

Use of nonsteroidal anti-inflammatory drugs and incidence of colorectal cancer: a population-based study

1 reference

12 December 2020

An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug

1 reference

12 December 2020

DCC: Linking tumour suppressor genes and altered cell surface interactions in cancer?

1 reference

12 December 2020

Role of caspase-3 in apoptosis of colon cancer cells induced by nonsteroidal anti-inflammatory drugs

1 reference

12 December 2020

P53 modulates the effect of loss of DNA mismatch repair on the sensitivity of human colon cancer cells to the cytotoxic and mutagenic effects of cisplatin

1 reference

12 December 2020

Apoptosis research is saving the reputation of chemotherapy

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12 December 2020

Clonal analysis using recombinant DNA probes from the X-chromosome

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12 December 2020

Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin

1 reference

12 December 2020

Flavopiridol: the first cyclin-dependent kinase inhibitor in human clinical trials

1 reference

12 December 2020

Recommendation for caution with irinotecan, fluorouracil, and leucovorin for colorectal cancer

1 reference

12 December 2020

Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group

1 reference

12 December 2020

Inhibition of Mouse Thymidylate Synthase Promoter Activity by the Wild-Type p53 Tumor Suppressor Protein

1 reference

12 December 2020

Toxicity of irinotecan in patients with colorectal cancer

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12 December 2020

A mathematical and computer-based model of alternating chemotherapy and radiation therapy in experimental neoplasms.

1 reference

12 December 2020

Human DNA-Topoisomerases - Diagnostic and Therapeutic Implications for Cancer

1 reference

12 December 2020

Effect of low molecular weight heparin (Certoparin) versus unfractionated heparin on cancer survival following breast and pelvic cancer surgery: A prospective randomized double-blind trial.

1 reference

12 December 2020

Enhancement of antitumor activity of ionizing radiation by combined treatment with the selective epidermal growth factor receptor-tyrosine kinase inhibitor ZD1839 (Iressa).

1 reference

12 December 2020

Disseminated tumour cells. Their detection and significance for prognosis of gastrointestinal and pancreatic carcinomas

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12 December 2020

Differential stabilization of eukaryotic DNA topoisomerase I cleavable complexes by camptothecin derivatives

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12 December 2020

Augmentation of apoptosis and tumor regression by flavopiridol in the presence of CPT-11 in Hct116 colon cancer monolayers and xenografts.

1 reference

12 December 2020

Irinotecan: mechanisms of tumor resistance and novel strategies for modulating its activity

1 reference

12 December 2020

Induction of biphasic DNA double strand breaks and activation of multiple repair protein complexes by DNA topoisomerase I drug 7-ethyl-10-hydroxy-camptothecin

1 reference

12 December 2020

New chemotherapy approaches in colorectal cancer

1 reference

12 December 2020

Increased expression of an ATP-binding cassette superfamily transporter, multidrug resistance protein 2, in human colorectal carcinomas.

1 reference

12 December 2020

Inhibited growth of colon cancer carcinomatosis by antibodies to vascular endothelial and epidermal growth factor receptors

1 reference

12 December 2020

The interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p53

1 reference

12 December 2020

Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

1 reference

12 December 2020

Chemotherapy of Colorectal Cancer

1 reference

12 December 2020

Cancer risk in patients with inflammatory bowel disease: a population-based study

1 reference

12 December 2020

P-glycoprotein-expressing tumor cells are resistant to anticancer drugs in human gastrointestinal cancer.

1 reference

12 December 2020

DNA strand-breaks induced by the topoisomerase I inhibitor camptothecin in unstimulated human white blood cells.

1 reference

12 December 2020

Clinical trial to assess the relative efficacy of fluorouracil and leucovorin, fluorouracil and levamisole, and fluorouracil, leucovorin, and levamisole in patients with Dukes' B and C carcinoma of the colon: results from National Surgical Adjuvant

1 reference

12 December 2020

Tumor size, sensitivity to therapy, and design of treatment schedules

1 reference

12 December 2020

STI571 (GLIVEC) induced hematologic, cytogenetic and molecular remission in a cml patient relapsing with accelerated phase after allogeneic stem cell transplantation

1 reference

12 December 2020

Molecular effects of topoisomerase II inhibitors in AML cell lines: correlation of apoptosis with topoisomerase II activity but not with DNA damage

1 reference

12 December 2020

Fluorouracil (5FU) pharmacokinetics in 5FU prodrug formulations with a dihydropyrimidine dehydrogenase inhibitor

1 reference

12 December 2020

Transport of topoisomerase I inhibitors by the breast cancer resistance protein. Potential clinical implications

1 reference

12 December 2020

Requirement for specific proteases in cancer cell intravasation as revealed by a novel semiquantitative PCR-based assay.

1 reference

12 December 2020

NSAIDs and gastrointestinal cancer prevention

1 reference

12 December 2020

The c-kit tyrosine kinase inhibitor STI571 for colorectal cancer therapy.

1 reference

12 December 2020

Application of cancer procoagulant as an early detection tumor marker

1 reference

12 December 2020

Prognostic value of tumoral thymidylate synthase and p53 in metastatic colorectal cancer patients receiving fluorouracil-based chemotherapy: phenotypic and genotypic analyses.

1 reference

12 December 2020

Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis

1 reference

12 December 2020

Germline and somatic mutation analyses in the DNA mismatch repair gene MLH3: Evidence for somatic mutation in colorectal cancers

1 reference

12 December 2020

10.1007/S00384-003-0496-X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12774240%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12774240%20AND%20SRC:MED&resulttype=core&format=json