(Q35103285)

6 August 2017

title

Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons (English)

1 reference

6 August 2017

0 references

1 reference

G Jean Harry

1 reference

6 August 2017

Donald C Lo

1 reference

6 August 2017

Linda S Kaltenbach

1 reference

6 August 2017

Andrew D Kraft

1 reference

6 August 2017

publication date

11 April 2011

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6 August 2017

published in

Neurobiology of Aging

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6 August 2017

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6 August 2017

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6 August 2017

page(s)

621.e17-33

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Composite primary neuronal high-content screening assay for Huntington's disease incorporating non-cell-autonomous interactions

6 August 2017

cites work

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CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease

9 July 2018

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C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production

9 July 2018

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9 July 2018

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Heterogeneity of microglia and TNF signaling as determinants for neuronal death or survival

9 July 2018

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Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals

9 July 2018

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9 July 2018

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A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

9 July 2018

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Debris clearance by microglia: an essential link between degeneration and regeneration.

9 July 2018

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Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease.

9 July 2018

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The classical complement cascade mediates CNS synapse elimination

9 July 2018

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Microglia: active sensor and versatile effector cells in the normal and pathologic brain

9 July 2018

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Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates

9 July 2018

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Imaging microglial activation in Huntington's disease

9 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

The corticostriatal pathway in Huntington's disease

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Normal huntingtin function: an alternative approach to Huntington's disease

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

A refined in vitro model to study inflammatory responses in organotypic membrane culture of postnatal rat hippocampal slices

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Synaptic dysfunction in Huntington's disease: a new perspective.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Microglia in health and disease

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Early changes in Huntington's disease patient brains involve alterations in cytoskeletal and synaptic elements

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Neuronal injury mediated via stimulation of microglial toll-like receptor-9 (TLR9).

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Huntington's disease: a synaptopathy?

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Microtubule destabilization and nuclear entry are sequential steps leading to toxicity in Huntington's disease

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Microglial activation by purines and pyrimidines

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Ultrastructural localization and progressive formation of neuropil aggregates in Huntington's disease transgenic mice

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Activation of microglial cells by beta-amyloid protein and interferon-gamma.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Excitotoxic degeneration is initiated at non-random sites in cultured rat cerebellar neurons

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Huntington's disease. Pathogenesis and management

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Abnormalities of striatal projection neurons and N-methyl-D-aspartate receptors in presymptomatic Huntington's disease

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Altered P2X7-receptor level and function in mouse models of Huntington's disease and therapeutic efficacy of antagonist administration.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington's disease

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Purines induce directed migration and rapid homing of microglia to injured pyramidal neurons in developing hippocampus

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Evidence for synaptic stripping by cortical microglia

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Microglial activation correlates with severity in Huntington disease: a clinical and PET study.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

CXCR3-dependent microglial recruitment is essential for dendrite loss after brain lesion.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Microglial activation and increased synthesis of complement component C1q precedes blood-brain barrier dysfunction in rats

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Microglia density decreases with age in a mouse model of Huntington's disease.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Modification of microglia function protects from lesion-induced neuronal alterations and promotes sprouting in the hippocampus

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Microglial activation and recruitment, but not proliferation, suffice to mediate neurodegeneration

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Amoeboid Microglial Cells and not Astrocytes Synthesize TNF-alpha in Swiss Mouse Brain Cell Cultures

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Microglial phagocytosis of apoptotic inflammatory T cells leads to down-regulation of microglial immune activation

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Early and progressive accumulation of reactive microglia in the Huntington disease brain

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Huntington aggregates may not predict neuronal death in Huntington's disease

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Increased complement biosynthesis by microglia and complement activation on neurons in Huntington's disease

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Axonal transport of N-terminal huntingtin suggests early pathology of corticostriatal projections in Huntington disease

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Biochemical abnormalities and excitotoxicity in Huntington's disease brain.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

The microglia/macrophage response in the neonatal rat facial nucleus following axotomy.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Neuronal transfection in brain slices using particle-mediated gene transfer.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135676

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

27 September 2018

1 reference

12 December 2020

Temporal profile and cellular localization of interleukin-6 protein after focal cerebral ischemia in rats

1 reference

12 December 2020

Microglial cells but not astrocytes undergo mitosis following rat facial nerve axotomy

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12 December 2020

Ramification of microglia, monocytes and macrophages in vitro: influences of various epithelial and mesenchymal cells and their conditioned media

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12 December 2020

Nature of the retrograde signal from injured nerves that induces interleukin-6 mRNA in neurons

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12 December 2020

Microglia: Intrinsic immuneffector cell of the brain

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12 December 2020

Neuron-microglia interactions in vitro

1 reference

12 December 2020

Displacement of synaptic terminals from regenerating motoneurons by microglial cells

1 reference

12 December 2020

Vitamin E induces ramification and downregulation of adhesion molecules in cultured microglial cells

1 reference

12 December 2020

10.1016/J.NEUROBIOLAGING.2011.02.015

Identifiers

DOI

1 reference

6 August 2017

1 reference

6 August 2017

1 reference