(Q35196538)

7 August 2017

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title

NF-kappaB in pancreatic cancer (English)

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7 August 2017

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Guido M Sclabas

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7 August 2017

Shuichi Fujioka

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7 August 2017

Christian Schmidt

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7 August 2017

Douglas B Evans

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7 August 2017

Paul J Chiao

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7 August 2017

publication date

1 January 2003

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International Journal of Gastrointestinal Cancer

7 August 2017

published in

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7 August 2017

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7 August 2017

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7 August 2017

page(s)

15-26

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TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway

7 August 2017

cites work

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12 December 2020

Structure of an IkappaBalpha/NF-kappaB complex

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12 December 2020

Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas

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12 December 2020

NF-kappa B: a pleiotropic mediator of inducible and tissue-specific gene control

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12 December 2020

Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas : a new marker of DPC4 inactivation

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12 December 2020

Increase of the resistance of human cervical carcinoma cells to cisplatin by inhibition of the MEK to ERK signaling pathway partly via enhancement of anticancer drug-induced NF kappa B activation

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12 December 2020

[Transcription factor NF-kappa B/RelA are constitutively activated and localized in the cell nuclei of E1A + cHa-Ras transformants]

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12 December 2020

The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells

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12 December 2020

IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

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12 December 2020

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

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12 December 2020

The EGF receptor family as targets for cancer therapy

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12 December 2020

An essential role for nuclear factor kappa B in preventing TNF-alpha-induced cell death in prostate cancer cells

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12 December 2020

Control of apoptosis by Rel/NF-kappaB transcription factors

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12 December 2020

The essential role of MEKK3 in TNF-induced NF-kappaB activation

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12 December 2020

Activation of oncogenicity of the c-rel proto-oncogene

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12 December 2020

The function of multiple IkappaB : NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosis

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12 December 2020

Induction of apoptosis of cytokine-producing bladder cancer cells by adenovirus-mediated IkappaBalpha overexpression

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12 December 2020

Identification and characterization of an IkappaB kinase

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12 December 2020

NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100

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12 December 2020

Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism

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12 December 2020

NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176

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12 December 2020

Genetic progression in the pancreatic ducts

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12 December 2020

The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways

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12 December 2020

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

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12 December 2020

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

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12 December 2020

Transcription factor NF-kappaB is constitutively activated in acute lymphoblastic leukemia cells.

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12 December 2020

The NF-kappa B cascade is important in Bcl-xL expression and for the anti-apoptotic effects of the CD28 receptor in primary human CD4+ lymphocytes

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12 December 2020

Mapping of a serine-rich domain essential for the transcriptional, antiapoptotic, and transforming activities of the v-Rel oncoprotein

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12 December 2020

Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

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12 December 2020

Constitutive IkappaB kinase activity correlates with nuclear factor-kappaB activation in human melanoma cells

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12 December 2020

Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses

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12 December 2020

Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF-kappaB and AP-1 activation and IL-8 and VEGF expression in human head and neck squamous cell carcinoma lines

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12 December 2020

Redox-sensitive transactivation of epidermal growth factor receptor by tumor necrosis factor confers the NF-kappa B activation.

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12 December 2020

Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness

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12 December 2020

Biphasic regulation of NF-kappa B activity underlies the pro- and anti-inflammatory actions of nitric oxide.

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12 December 2020

Regulation of NF-kappaB activity by I kappaB-related proteins in adenocarcinoma cells

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12 December 2020

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

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12 December 2020

Transcriptional regulation of the bcl-x gene encoding the anti-apoptotic Bcl-xL protein by Ets, Rel/NFkappaB, STAT and AP1 transcription factor families

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12 December 2020

I kappa B: a specific inhibitor of the NF-kappa B transcription factor

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12 December 2020

Gene transfer for angiogenesis in coronary artery disease.

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12 December 2020

Structure, regulation and function of NF-kappa B

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12 December 2020

The Hallmarks of Cancer

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12 December 2020

Complete lack of NF-kappaB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation

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12 December 2020

Inhibition of NF kappa B activation by pyrrolidine dithiocarbamate prevents in vivo hypoxia/reoxygenation-mediated myocardial angiogenesis.

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12 December 2020

Defective IkappaBalpha in Hodgkin cell lines with constitutively active NF-kappaB.

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12 December 2020

Epidermal growth factor-induced nuclear factor kappa B activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells

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12 December 2020

Epidermal growth factor activation of NF-kappaB is mediated through IkappaBalpha degradation and intracellular free calcium

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12 December 2020

Autoregulation of I kappa B alpha activity

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12 December 2020

Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10 by fluorescence in situ hybridization

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12 December 2020

A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB.

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12 December 2020

Pathways of apoptosis in lymphocyte development, homeostasis, and disease

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12 December 2020

Activators and target genes of Rel/NF-kappaB transcription factors

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12 December 2020

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

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12 December 2020

Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta

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12 December 2020

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

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12 December 2020

In vivo control of NF-kappa B activation by I kappa B alpha.

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12 December 2020

Altered expression of the p50 subunit of the NF-kappa B transcription factor complex in non-small cell lung carcinoma

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12 December 2020

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control

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12 December 2020

Focus on pancreas cancer

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12 December 2020

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

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12 December 2020

The NF-kappa B and I kappa B proteins: new discoveries and insights

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12 December 2020

Molecular pathology of pancreatic cancer

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12 December 2020

Oncogenic Ha-Ras-induced Signaling Activates NF-κB Transcriptional Activity, Which Is Required for Cellular Transformation

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12 December 2020

NEMO/IKK gamma-deficient mice model incontinentia pigmenti.

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12 December 2020

Constitutive nuclear NF kappa B/rel DNA-binding activity of rat thymocytes is increased by stimuli that promote apoptosis, but not inhibited by pyrrolidine dithiocarbamate

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12 December 2020

Bryostatin 1 induces differentiation and potentiates the antitumor effect of Auristatin PE in a human pancreatic tumor (PANC-1) xenograft model

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12 December 2020

Activation of NF-kappaB/Rel occurs early during neoplastic transformation of mammary cells

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12 December 2020

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

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12 December 2020

The expanding role of mitochondria in apoptosis

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12 December 2020

Reactive oxygen and NF-kappaB in VEGF-induced migration of human vascular smooth muscle cells

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12 December 2020

Bcl-2 Suppresses Apoptosis Resulting from Disruption of the NF-κB Survival Pathway☆

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12 December 2020

Function of nuclear factor kappaB in pancreatic cancer metastasis

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12 December 2020

Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice.

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12 December 2020

NF-kappa B: ten years after

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12 December 2020

Multiple Hemopoietic Defects and Lymphoid Hyperplasia in Mice Lacking the Transcriptional Activation Domain of the c-Rel Protein

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12 December 2020

Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice

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12 December 2020

The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L).

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12 December 2020

Progression model for pancreatic cancer.

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12 December 2020

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

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12 December 2020

ch-IAP1, a Member of the Inhibitor-of-Apoptosis Protein Family, Is a Mediator of the Antiapoptotic Activity of the v-Rel Oncoprotein

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12 December 2020

Alteration of integrins by interleukin-1alpha in human pancreatic cancer cells

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12 December 2020

Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFkappaB p65 protein expression.

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12 December 2020

Phorbol ester reduces constitutive nuclear NF kappa B and inhibits HIV-1 production in mature human monocytic cells

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12 December 2020

NF-kappaB regulation in the immune system

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12 December 2020

Mechanism for biphasic rel A. NF-kappaB1 nuclear translocation in tumor necrosis factor alpha-stimulated hepatocytes

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12 December 2020

Autocrine production of interleukin 1beta confers constitutive nuclear factor kappaB activity and chemoresistance in pancreatic carcinoma cell lines

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12 December 2020

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

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12 December 2020

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

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12 December 2020

How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex

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12 December 2020

Deficient natural killer cell cytotoxicity in patients with IKK-gamma/NEMO mutations

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12 December 2020

Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA

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12 December 2020

Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth

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12 December 2020

Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate

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12 December 2020

Coexpression of proangiogenic factors IL-8 and VEGF by human head and neck squamous cell carcinoma involves coactivation by MEK-MAPK and IKK-NF-kappaB signal pathways.

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12 December 2020

IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival

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12 December 2020

Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis.

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12 December 2020

Induction of p21waf1 expression and growth inhibition by transforming growth factor beta involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells

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12 December 2020

Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha.

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12 December 2020

Hypoxia/reoxygenation promotes myocardial angiogenesis via an NF kappa B-dependent mechanism in a rat model of chronic myocardial infarction

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12 December 2020

IKK1-deficient mice exhibit abnormal development of skin and skeleton

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12 December 2020

The Epidermal Growth Factor Receptor Associates with and Recruits Phosphatidylinositol 3-Kinase to the Platelet-derived Growth Factor β Receptor

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12 December 2020

Raf-induced transformation requires an interleukin 1 autocrine loop.

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12 December 2020

Elevated constitutive IkappaB kinase activity and IkappaB-alpha phosphorylation in Hs294T melanoma cells lead to increased basal MGSA/GRO-alpha transcription

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12 December 2020

Specificities of CD40 signaling: involvement of TRAF2 in CD40-induced NF-kappaB activation and intercellular adhesion molecule-1 up-regulation

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12 December 2020

MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration.

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12 December 2020

Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice

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12 December 2020

Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer.

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12 December 2020

The IKK-2/Ikappa Balpha /NF-kappa B pathway plays a key role in the regulation of CCR3 and eotaxin-1 in fibroblasts. A critical link to dermatitis in Ikappa Balpha -deficient mice

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12 December 2020

Enhanced expression of epidermal growth factor receptor correlates with alterations of chromosome 7 in human pancreatic cancer

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12 December 2020

Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti

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12 December 2020

The Rel/NF-kappaB signal transduction pathway: introduction

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12 December 2020

v-Rel prevents apoptosis in transformed lymphoid cells and blocks TNFα-induced cell death

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12 December 2020

Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway

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12 December 2020

Angiogenesis and Tumor Metastasis

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12 December 2020

PRAD1/lCyclin D1 proto‐oncogene: Genomic organization, 5′ dna sequence, and sequence of a tumor‐specific rearrangement breakpoint

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12 December 2020

The involvement of NF-kappa B in beta-interferon gene regulation reveals its role as widely inducible mediator of signal transduction

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12 December 2020

An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway

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12 December 2020

The NF-kappa B transcription factor and cancer: high expression of NF-kappa B- and I kappa B-related proteins in tumor cell lines

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12 December 2020

Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity

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12 December 2020

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation

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12 December 2020

Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer

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12 December 2020

Antioxidants inhibit cytokine production and suppress NF-kappaB activation in CAPAN-1 and CAPAN-2 cell lines

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12 December 2020

Effect of antisense oligodeoxynucleotide directed to NF-kappa B-RelA on Bcl-XL mRNA in extended drug resistance leukemia cell line HL-60/E6.

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12 December 2020

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

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12 December 2020

Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene

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12 December 2020

Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesis

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12 December 2020

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis

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12 December 2020

Destabilizing influences in apoptosis: sowing the seeds of IAP destruction

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12 December 2020

Mechanisms of constitutive NF-kappaB activation in human prostate cancer cells

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12 December 2020

Enhanced VEGF production and decreased immunogenicity induced by TGF-beta 1 promote liver metastasis of pancreatic cancer

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12 December 2020

Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells.

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12 December 2020

I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B

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12 December 2020

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12 December 2020

Transformation of avian lymphoid cells by reticuloendotheliosis virus

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12 December 2020

VEGF as a mediator of tumor-associated immunodeficiency

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12 December 2020

The v-Rel oncoprotein blocks apoptosis and proteolysis of I kappa B-alpha in transformed chicken spleen cells

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12 December 2020

Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by kappa B elements

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12 December 2020

Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras

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12 December 2020

Inhibition of NF-kappaB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin

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12 December 2020

A novel NF-kappa B-inducing kinase-MAPK signaling pathway up-regulates NF-kappa B activity in melanoma cells

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12 December 2020

Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha

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12 December 2020

Negative regulation of transactivation function but not DNA binding of NF-kappaB and AP-1 by IkappaBbeta1 in breast cancer cells

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12 December 2020

Epidermal growth factor-related peptides and their receptors in human malignancies

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12 December 2020

Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB

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12 December 2020

The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome

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12 December 2020

Missing pieces in the NF-kappaB puzzle

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12 December 2020

Oxidative stress due to hypoxia/reoxygenation induces angiogenic factor VEGF in adult rat myocardium: possible role of NFkappaB.

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12 December 2020

Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

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12 December 2020

Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase

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12 December 2020

Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis

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12 December 2020

NF-kappa B is induced in the nuclei of cultured rat aortic smooth muscle cells by stimulation of various growth factors

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12 December 2020

The c-erb B-2 proto-oncogene in human pancreatic cancer

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12 December 2020

NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway

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12 December 2020

Effects of the proteasome inhibitor PS-341 on apoptosis and angiogenesis in orthotopic human pancreatic tumor xenografts.

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12 December 2020

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

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12 December 2020

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

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12 December 2020

MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

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12 December 2020

Curcumin inhibits interleukin 8 production and enhances interleukin 8 receptor expression on the cell surface:impact on human pancreatic carcinoma cell growth by autocrine regulation

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12 December 2020

Clinicopathological significance of epidermal growth factor and its receptor in human pancreatic cancer

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12 December 2020

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

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12 December 2020

Apoptosis: a link between cancer genetics and chemotherapy

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12 December 2020

Identifiers

DOI

10.1385/IJGC:33:1:15

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release_ia2scnhi6reenkmsfohilna5iu

7 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ia2scnhi6reenkmsfohilna5iu

24 November 2022

mapped directly with Wikidata item

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