(Q35192575)

7 August 2017

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title

Recognition of microbial infection by Toll-like receptors (English)

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7 August 2017

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Ruslan Medzhitov

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7 August 2017

Elizabeth Kopp

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7 August 2017

publication date

1 August 2003

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Current Opinion in Immunology

7 August 2017

published in

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7 August 2017

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7 August 2017

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7 August 2017

page(s)

396-401

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Toll-like receptors control activation of adaptive immune responses

7 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Toll-like receptors and innate immunity

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

1 reference

7 January 2021

Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Endotoxin contamination in recombinant human heat shock protein 70 (Hsp70) preparation is responsible for the induction of tumor necrosis factor alpha release by murine macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

IRAK: a kinase associated with the interleukin-1 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

IRAK-M is a negative regulator of Toll-like receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Endotoxin-induced maturation of MyD88-deficient dendritic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Unresponsiveness of MyD88-deficient mice to endotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

TIRAP: an adapter molecule in the Toll signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Toll-like receptor 2 participates in mediation of immune response in experimental pneumococcal meningitis

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Cutting edge: Toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdorferi

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Toll-like receptor 4 mediates innate immune responses to Haemophilus influenzae infection in mouse lung

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Toll-like receptor 4 expression is required to control chronic Mycobacterium tuberculosis infection in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Involvement of toll-like receptor 4 in innate immunity to respiratory syncytial virus

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Respiratory syncytial virus-induced activation of nuclear factor-kappaB in the lung involves alveolar macrophages and toll-like receptor 4-dependent pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

IRF3 mediates a TLR3/TLR4-specific antiviral gene program

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

Pyogenic bacterial infections in humans with IRAK-4 deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2803%2900080-3

7 January 2021

10.1016/S0952-7915(03)00080-3

Identifiers

DOI

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7 August 2017

1 reference