(Q35157702)

6 August 2017

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title

Molecular mechanisms underlying osteoclast formation and activation (English)

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6 August 2017

Bruce R Troen

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6 August 2017

publication date

1 June 2003

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6 August 2017

published in

Experimental Gerontology

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6 August 2017

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6 August 2017

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6 August 2017

page(s)

605-614

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A RANK/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive function

6 August 2017

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7 January 2021

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Sex steroids, mice, and men: when androgens and estrogens get very close to each other

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7 January 2021

Specific binding of estrogen to osteoclast surfaces

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7 January 2021

Expression of RANKL and OPG correlates with age-related bone loss in male C57BL/6 mice

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7 January 2021

Effect of Testosterone and Estradiol in a Man with Aromatase Deficiency

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7 January 2021

In vitro secretion of cytokines by human bone marrow: effects of age and estrogen status

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7 January 2021

Regulation of osteoclast differentiation by fibroblast growth factor 2: stimulation of receptor activator of nuclear factor kappaB ligand/osteoclast differentiation factor expression in osteoblasts and inhibition of macrophage colony-stimulating fac

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7 January 2021

Deflazacort increases osteoclast formation in mouse bone marrow culture and the ratio of RANKL/OPG mRNA expression in marrow stromal cells

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7 January 2021

Tumor necrosis factor-α mediates polymethylmethacrylate particle-induced NF-κB activation in osteoclast precursor cells

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7 January 2021

New insights into the regulation of cathepsin K gene expression by osteoprotegerin ligand

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7 January 2021

Histamine stimulates production of osteoclast differentiation factor/receptor activator of nuclear factor-kappaB ligand by osteoblasts

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7 January 2021

Cathepsin K mRNA detection is restricted to osteoclasts during fetal mouse development

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7 January 2021

RANK is essential for osteoclast and lymph node development

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7 January 2021

Osteoclasts secrete the chemotactic cytokine mim-1.

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7 January 2021

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7 January 2021

Macrophage colony stimulating factor restores in vivo bone resorption in the op/op osteopetrotic mouse

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7 January 2021

Skeletal effects of estrogens

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7 January 2021

Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency

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7 January 2021

Cathepsin K Knockout Mice Develop Osteopetrosis Due to a Deficit in Matrix Degradation but Not Demineralization

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7 January 2021

Endogenous Sex Steroids and Bone Mineral Density in Older Women and Men: The Rancho Bernardo Study

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7 January 2021

c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling

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7 January 2021

Macrophage colony-stimulating factor suppresses osteoblast formation

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7 January 2021

Effects of age on serum dehydroepiandrosterone sulfate, IGF-I, and IL-6 levels in women

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7 January 2021

Interleukin-1beta and tumor necrosis factor-alpha, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells

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7 January 2021

Cytokines and estrogen in bone: anti-osteoporotic effects

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7 January 2021

Characterization of novel cathepsin K mutations in the pro and mature polypeptide regions causing pycnodysostosis.

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7 January 2021

Demonstration of estrogen receptor mRNA in bone using in situ reverse-transcriptase polymerase chain reaction

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7 January 2021

Osteopetrosis in mice lacking NF-κB1 and NF-κB2

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7 January 2021

Molecular genetics of too much bone

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7 January 2021

Interleukin 1 induces multinucleation and bone-resorbing activity of osteoclasts in the absence of osteoblasts/stromal cells

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7 January 2021

A nonsense mutation in the cathepsin K gene observed in a family with pycnodysostosis

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7 January 2021

The effects of oestrogens on linear bone growth

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7 January 2021

Estrogen Inhibits Bone Resorption by Directly Inducing Apoptosis of the Bone-resorbing Osteoclasts

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7 January 2021

Vector-averaged gravity regulates gene expression of receptor activator of NF-kappaB (RANK) ligand and osteoprotegerin in bone marrow stromal cells via cyclic AMP/protein kinase A pathway

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7 January 2021

Regulatory mechanisms of osteoblast and osteoclast differentiation

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7 January 2021

Independent impairment of osteoblast and osteoclast differentiation in klotho mouse exhibiting low-turnover osteopenia

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7 January 2021

Oestrogen, bones and men: when testosterone just isn't enough.

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7 January 2021

Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors

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7 January 2021

Accelerated turnover of metaphyseal trabecular bone in mice overexpressing cathepsin K

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7 January 2021

Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis

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7 January 2021

Essential role of macrophage colony-stimulating factor in the osteoclast differentiation supported by stromal cells

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7 January 2021

Congenital osteoclast deficiency in osteopetrotic (op/op) mice is cured by injections of macrophage colony-stimulating factor

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7 January 2021

Tumor necrosis factor-alpha cooperates with receptor activator of nuclear factor kappaB ligand in generation of osteoclasts in stromal cell-depleted rat bone marrow cell culture

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7 January 2021

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

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7 January 2021

Osteoclastogenic potential of bone marrow cells increases with age in elderly women with fracture

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7 January 2021

Estrogen modulation of osteoclast lysosomal enzyme secretion

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7 January 2021

Platelet-derived growth factor BB secreted from osteoclasts acts as an osteoblastogenesis inhibitory factor

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7 January 2021

Mechanical strain effect on bone-resorbing activity and messenger RNA expressions of marker enzymes in isolated osteoclast culture

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7 January 2021

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation

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7 January 2021

Enforced Expression of Bcl-2 in Monocytes Rescues Macrophages and Partially Reverses Osteopetrosis in op/op Mice

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7 January 2021

Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone

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7 January 2021

Parathyroid hormone stimulates TRANCE and inhibits osteoprotegerin messenger ribonucleic acid expression in murine bone marrow cultures: correlation with osteoclast-like cell formation

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7 January 2021

Effects of prostaglandin E2 on gene expression in primary osteoblastic cells from prostaglandin receptor knockout mice

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7 January 2021

Two different pathways for the maintenance of trabecular bone in adult male mice

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7 January 2021

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

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7 January 2021

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7 January 2021

Modulation of the effects of osteoprotegerin (OPG) ligand in a human leukemic cell line by OPG and calcitonin

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7 January 2021

Mammalian mature osteoclasts as estrogen target cells

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7 January 2021

The role of IL-6 type cytokines and their receptors in bone

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7 January 2021

Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis

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7 January 2021

Sex steroids and bone

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7 January 2021

Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-kappa B ligand signaling

1 reference

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7 January 2021

Activation of p38 mitogen-activated protein kinase is crucial in osteoclastogenesis induced by tumor necrosis factor

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7 January 2021

A novel interaction between thyroid hormones and 1,25(OH)(2)D(3) in osteoclast formation

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7 January 2021

Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin

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7 January 2021

Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens

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7 January 2021

Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice

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7 January 2021

Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis

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7 January 2021

Expression of estrogen receptor-alpha in cells of the osteoclastic lineage

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7 January 2021

Osteoclast synthesis and secretion and activation of latent transforming growth factor beta

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7 January 2021

Avian osteoclasts as estrogen target cells

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7 January 2021

Human giant cell tumors of the bone (osteoclastomas) are estrogen target cells

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7 January 2021

Osteoclasts isolated from membranous bone in children exhibit nuclear estrogen and progesterone receptors.

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7 January 2021

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7 January 2021

Transforming growth factor beta affects osteoclast differentiation via direct and indirect actions.

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7 January 2021

Involutional osteoporosis

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7 January 2021

A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men.

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7 January 2021

Cell biology of the osteoclast

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7 January 2021

IGF-I regulates osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand in vitro and OPG in vivo.

1 reference

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7 January 2021

Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice

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7 January 2021

The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation

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7 January 2021

Inhibition of bone resorption by 17beta-estradiol in human bone marrow cultures

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7 January 2021

Estrogens suppress RANK ligand-induced osteoclast differentiation via a stromal cell independent mechanism involving c-Jun repression

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7 January 2021

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

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7 January 2021

Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man

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7 January 2021

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

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7 January 2021

The actions and interactions of sex steroids and growth factors/cytokines on the skeleton

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7 January 2021

Estrogen decreases TNF gene expression by blocking JNK activity and the resulting production of c-Jun and JunD.

1 reference

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7 January 2021

Estrogen decreases osteoclast formation by down-regulating receptor activator of NF-kappa B ligand (RANKL)-induced JNK activation

1 reference

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7 January 2021

Potent and selective inhibition of human cathepsin K leads to inhibition of bone resorption in vivo in a nonhuman primate

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7 January 2021

Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families

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7 January 2021

Lipopolysaccharide supports survival and fusion of preosteoclasts independent of TNF-alpha, IL-1, and RANKL.

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7 January 2021

Estrogen's bone-protective effects may involve differential IL-1 receptor regulation in human osteoclast-like cells

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7 January 2021

A new member of tumor necrosis factor ligand family, ODF/OPGL/TRANCE/RANKL, regulates osteoclast differentiation and function

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7 January 2021

Transforming growth factor-beta stimulates the production of osteoprotegerin/osteoclastogenesis inhibitory factor by bone marrow stromal cells

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900069-X

7 January 2021

T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ

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7 January 2021

Osteopetrosis in mice lacking haematopoietic transcription factor PU.1.

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7 January 2021

Expression and localization of estrogen receptor-beta in murine and human bone

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7 January 2021

Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice

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7 January 2021

Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts.

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7 January 2021

Receptor activator of nuclear factor-kappa b ligand activates nuclear factor-kappa b in osteoclast precursors

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7 January 2021

Regulation of avian osteoclastic H+ -ATPase and bone resorption by tamoxifen and calmodulin antagonists. Effects independent of steroid receptors

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https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900069-X

7 January 2021

The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900069-X

7 January 2021

TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900069-X

7 January 2021

Localization of rat cathepsin K in osteoclasts and resorption pits: inhibition of bone resorption and cathepsin K-activity by peptidyl vinyl sulfones

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900069-X

7 January 2021

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900069-X

7 January 2021

Cathepsin K, osteoclastic resorption, and osteoporosis therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900069-X

7 January 2021

Tumor necrosis factor-alpha (TNF) stimulates RANKL-induced osteoclastogenesis via coupling of TNF type 1 receptor and RANK signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2803%2900069-X

7 January 2021

10.1016/S0531-5565(03)00069-X

Identifiers

DOI

1 reference

6 August 2017

1 reference