(Q35145883)

6 August 2017

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title

Modifier genes and protective alleles in humans and mice (English)

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6 August 2017

Joseph H Nadeau

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6 August 2017

publication date

1 June 2003

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Current Opinion in Genetics & Development

6 August 2017

published in

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6 August 2017

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6 August 2017

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6 August 2017

page(s)

290-295

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Modifier genes in mice and humans

6 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Phenotypic diversity, allelic series and modifier genes

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7 January 2021

Monogenic traits are not simple: lessons from phenylketonuria

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7 January 2021

Phenotypes of patients with "simple" Mendelian disorders are complex traits: thresholds, modifiers, and systems dynamics

1 reference

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7 January 2021

Mouse models for human deafness: current tools for new fashions

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https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Genetic modifiers of vision and hearing

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Genetic modifier loci affecting survival and cardiac function in murine dilated cardiomyopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Vestibular dysfunction in the epistatic circler mouse is caused by phenotypic interaction of one recessive gene and three modifier genes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Genetic modifiers that aggravate the neurological phenotype of the wobbler mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Quantitative trait loci influence renal disease progression in a mouse model of Alport syndrome

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7 January 2021

A polymorphic modifier gene alters the hypertrophic response in a murine model of familial hypertrophic cardiomyopathy

1 reference

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7 January 2021

Leptin-deficient mice backcrossed to the BALB/cJ genetic background have reduced adiposity, enhanced fertility, normal body temperature, and severe diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Molecular and pathological effects of a modifier gene on deficiency of the sodium channel Scn8a (Na(v)1.6).

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Cochlear and retinal degeneration in the tubby mouse

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https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Molecular mapping of the tubby (tub) mutation on mouse chromosome 7

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

A candidate gene for the mouse mutation tubby

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Microtubule-associated protein 1A is a modifier of tubby hearing (moth1).

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Isolation and characterization of the putative nuclear modifier gene MTO1 involved in the pathogenesis of deafness-associated mitochondrial 12 S rRNA A1555G mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

The MICA region determines the first modifier locus in familial Mediterranean fever

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Detection of modifier loci influencing the lung phenotype of cystic fibrosis knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Loci of intestinal distress in cystic fibrosis knockout mice

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https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Mapping of genetic factors influencing the weight of cystic fibrosis knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Deletion of cytosolic phospholipase A(2) suppresses Apc(Min)-induced tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Identification of the modifier of Min 2 (Mom2) locus, a new mutation that influences Apc-induced intestinal neoplasia.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

mdfw:A Deafness Susceptibility Locus That Interacts with Deaf Waddler (dfw)

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Hearing loss associated with the modifier of deaf waddler (mdfw) locus corresponds with age-related hearing loss in 12 inbred strains of mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Detection of a cystic fibrosis modifier locus for meconium ileus on human chromosome 19q13.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Characterization of a major modifier locus for polycystic kidney disease (Modpkdr1) in the Han:SPRD(cy/+) rat in a region conserved with a mouse modifier locus for Alport syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Early onset of severe familial amyotrophic lateral sclerosis with a SOD-1 mutation: potential impact of CNTF as a candidate modifier gene

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

32 bp CCR-5 gene deletion and resistance to fast progression in HIV-1 infected heterozygotes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

HIV-1-resistance phenotype conferred by combination of two separate inherited mutations of CCR5 gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

A novel susceptibility locus on chromosome 2 in the (New Zealand Black x New Zealand White)F1 hybrid mouse model of systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Genetic susceptibility to breast cancer: HLA DQB*03032 and HLA DRB1*11 may represent protective alleles

1 reference

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7 January 2021

Protective effect of interleukin-4 -589T polymorphism on human immunodeficiency virus type 1 disease progression: relationship with virus load

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Human leukocyte antigen-DRB1 position 11 residues are a common protective marker for sarcoidosis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Delineating the genetic basis of systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Epistatic modifiers of autoimmunity in a murine model of lupus nephritis

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https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Genetic modifiers of systemic lupus erythematosus in FcgammaRIIB(-/-) mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

IS THERE A CONSTANT FITNESS VALUE FOR A GIVEN GENOTYPE? NO!

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

The Evolutionary Development of Modifier Genes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Towards a theory of the evolution of modifier genes.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Robustness against mutations in genetic networks of yeast.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Modeling genetic networks and their evolution: a complex dynamical systems perspective

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Developmental evolution: getting robust about robustness

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

Biochemical networking contributes more to genetic buffering in human and mouse metabolic pathways than does gene duplication

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900061-3

7 January 2021

10.1016/S0959-437X(03)00061-3

Identifiers

DOI

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6 August 2017

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