(Q35092287)

6 August 2017

1 reference

title

Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease (English)

1 reference

6 August 2017

0 references

Judes Poirier

1 reference

6 August 2017

publication date

1 March 2003

1 reference

Trends in Molecular Medicine

6 August 2017

published in

1 reference

6 August 2017

1 reference

6 August 2017

1 reference

6 August 2017

page(s)

94-101

1 reference

New frontiers in Alzheimer's disease genetics

6 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Apolipoprotein E polymorphism and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Prediction of cognitive decline in normal elderly subjects with 2-[(18)F]fluoro-2-deoxy-D-glucose/positron-emission tomography (FDG/PET).

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Declining brain activity in cognitively normal apolipoprotein E epsilon 4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Caloric intake and the risk of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Joint effect of the APOE gene and midlife systolic blood pressure on late-life cognitive impairment: the Honolulu-Asia aging study

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. Alzheimer's Disease Cooperative Study

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Tangle-bearing neurons contain more free cholesterol than adjacent tangle-free neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Reduced levels of cholesterol, phospholipids, and fatty acids in cerebrospinal fluid of Alzheimer disease patients are not related to apolipoprotein E4.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (type I) and demyelination in late-onset form (type II).

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Evidence for changes in the Alzheimer's disease brain cortical membrane structure mediated by cholesterol

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Serum lipoprotein pattern variations in dementia and ischemic stroke.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Amyloid and lipids in the pathology of Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

A full genome scan for late onset Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

3-hydroxy-3-methylglutaryl-coenzyme A reductase mRNA in Alzheimer and control brain

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult rats

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Apolipoprotein E, synaptic plasticity and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Apolipoprotein E isoform-specific reduction of extracellular amyloid in neuronal cultures

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Therapeutic potential of ACAT inhibitors as lipid lowering and anti-atherosclerotic agents

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Diet-induced hypercholesterolemia enhances brain A beta accumulation in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Modulation of secreted beta-amyloid precursor protein and amyloid beta-peptide in brain by cholesterol

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Apolipoprotein E, plaques, tangles and cholinergic dysfunction in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Characterization of peroxisomal 3-hydroxy-3-methylglutaryl coenzyme A reductase in UT2 cells: sterol biosynthesis, phosphorylation, degradation, and statin inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

HMG CoA reductase: a negatively regulated gene with unusual promoter and 5' untranslated regions

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

A highly conserved signal controls degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase in eukaryotes

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Statins and the risk of dementia

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Treatment with controlled-release lovastatin decreases serum concentrations of human beta-amyloid (A beta) peptide

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Alzheimer's disease: the amyloid cascade hypothesis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900007-8

7 January 2021

10.1016/S1471-4914(03)00007-8

Identifiers

DOI

1 reference

6 August 2017

1 reference