(Q35078620)

6 August 2017

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title

Toll-like receptors and their role in experimental models of microbial infection (English)

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6 August 2017

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R Medzhitov

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6 August 2017

Salman T Qureshi

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6 August 2017

publication date

1 March 2003

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6 August 2017

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6 August 2017

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6 August 2017

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6 August 2017

page(s)

87-94

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Innate immunity: the virtues of a nonclonal system of recognition

6 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Toll-like receptors control activation of adaptive immune responses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Innate immune recognition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

A family of human receptors structurally related to Drosophila Toll

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

A conserved signaling pathway: the Drosophila toll-dorsal pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Toll receptor-mediated Drosophila immune response requires Dif, an NF-kappaB factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Drosophila innate immunity: an evolutionary perspective

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Toll-like receptors and innate immunity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

TIRAP: an adapter molecule in the Toll signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Negative regulation of toll-like receptor-mediated signaling by Tollip

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

1 reference

7 January 2021

Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

PU.1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Transcriptional regulation of the human toll-like receptor 2 gene in monocytes and macrophages

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

1 reference

7 January 2021

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

A Toll-like receptor recognizes bacterial DNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guérin: involvement of toll-like receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

The Trypanosoma cruzi Tc52-released protein induces human dendritic cell maturation, signals via Toll-like receptor 2, and confers protection against lethal infection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Monocytic cell activation by Nonendotoxic glycoprotein from Prevotella intermedia ATCC 25611 is mediated by toll-like receptor 2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Toll-like receptor-2 mediates Treponema glycolipid and lipoteichoic acid-induced NF-kappaB translocation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Discrimination of bacterial lipoproteins by Toll-like receptor 6

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Toll-like receptor 4 mediates intracellular signaling without TNF-alpha release in response to Cryptococcus neoformans polysaccharide capsule

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Involvement of CD14 and toll-like receptors in activation of human monocytes by Aspergillus fumigatus hyphae

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

LPS-hyporesponsiveness of mnd mice is associated with a mutation in Toll-like receptor 4

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Mouse genetic locus Lps influences susceptibility to Neisseria meningitidis infection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Toll-like receptor 4 mediates innate immune responses to Haemophilus influenzae infection in mouse lung

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

A functional polymorphism of toll-like receptor 4 is not associated with likelihood or severity of meningococcal disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Complex genetic control of susceptibility to malaria in mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Involvement of toll-like receptor 4 in innate immunity to respiratory syncytial virus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdorferi

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Genetic control of resistance to experimental infection with virulent Mycobacterium tuberculosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Genetic control of susceptibility to infection with Mycobacterium tuberculosis in mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

The extra domain A of fibronectin activates Toll-like receptor 4.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GENE.6363937

7 January 2021

Identifiers

DOI

10.1038/SJ.GENE.6363937

1 reference

6 August 2017

1 reference