(Q35072863)

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Cytosolic retinoid dehydrogenases govern ubiquitous metabolism of retinol to retinaldehyde followed by tissue-specific metabolism to retinoic acid

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Europe PubMed Central

PubMed publication ID

6 August 2017

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Europe PubMed Central

Cytosolic retinoid dehydrogenases govern ubiquitous metabolism of retinol to retinaldehyde followed by tissue-specific metabolism to retinoic acid (English)

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Europe PubMed Central

PubMed publication ID

6 August 2017

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Gregg Duester

1

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author name string

Felix A Mic

2

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Europe PubMed Central

PubMed publication ID

6 August 2017

Andrei Molotkov

3

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Europe PubMed Central

PubMed publication ID

6 August 2017

publication date

1 February 2003

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Europe PubMed Central

PubMed publication ID

6 August 2017

Chemico-biological Interactions

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Europe PubMed Central

PubMed publication ID

6 August 2017

143-144

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Europe PubMed Central

PubMed publication ID

6 August 2017

201-210

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid

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Local application of retinoic acid to the limb bond mimics the action of the polarizing region

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Abnormal anteroposterior and dorsoventral patterning of the limb bud in the absence of retinoids.

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7 January 2021

Vitamin A-deficient quail embryos have half a hindbrain and other neural defects

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Retinoid signalling and hindbrain patterning.

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Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neurons

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A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord

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Assigning the positional identity of spinal motor neurons: rostrocaudal patterning of Hox-c expression by FGFs, Gdf11, and retinoids.

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7 January 2021

Retinoic Acid in the Formation of the Dorsoventral Retina and Its Central Projections

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7 January 2021

Vitamin A controls epithelial/mesenchymal interactions through Ret expression

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7 January 2021

RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.

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7 January 2021

Genetic analysis of RXR alpha developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis.

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7 January 2021

Compound mutants for retinoic acid receptor (RAR) beta and RAR alpha 1 reveal developmental functions for multiple RAR beta isoforms.

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7 January 2021

Cellular retinol-binding protein I is essential for vitamin A homeostasis.

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7 January 2021

Retinoic acid synthesis in mouse embryos during gastrulation and craniofacial development linked to class IV alcohol dehydrogenase gene expression

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7 January 2021

Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis

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Restricted expression and retinoic acid-induced downregulation of the retinaldehyde dehydrogenase type 2 (RALDH-2) gene during mouse development.

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Distinct functions for Aldh1 and Raldh2 in the control of ligand production for embryonic retinoid signaling pathways

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Identification of endogenous retinoids, enzymes, binding proteins, and receptors during early postimplantation development in mouse: important role of retinal dehydrogenase type 2 in synthesis of all-trans-retinoic acid

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Embryonic retinoic acid synthesis is essential for early mouse post-implantation development

1 reference

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7 January 2021

Aldehyde dehydrogenase 6, a cytosolic retinaldehyde dehydrogenase prominently expressed in sensory neuroepithelia during development

1 reference

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7 January 2021

A retinoic acid synthesizing enzyme in ventral retina and telencephalon of the embryonic mouse

1 reference

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7 January 2021

RALDH3, a retinaldehyde dehydrogenase that generates retinoic acid, is expressed in the ventral retina, otic vesicle and olfactory pit during mouse development.

1 reference

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7 January 2021

Identification of RALDH-3, a novel retinaldehyde dehydrogenase, expressed in the ventral region of the retina

1 reference

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7 January 2021

Tissue-specific expression of retinoic acid receptor isoform transcripts in the mouse embryo.

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7 January 2021

Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family

1 reference

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7 January 2021

Short-chain dehydrogenases/reductases (SDR)

1 reference

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A new nomenclature for the aldo-keto reductase superfamily

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Relationships within the aldehyde dehydrogenase extended family

1 reference

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7 January 2021

Interactions of retinoid binding proteins and enzymes in retinoid metabolism

1 reference

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7 January 2021

Involvement of alcohol dehydrogenase, short-chain dehydrogenase/reductase, aldehyde dehydrogenase, and cytochrome P450 in the control of retinoid signaling by activation of retinoic acid synthesis

1 reference

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7 January 2021

A vertebrate aldo-keto reductase active with retinoids and ethanol

1 reference

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7 January 2021

Organization of six functional mouse alcohol dehydrogenase genes on two overlapping bacterial artificial chromosomes

1 reference

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7 January 2021

Expression patterns of class I and class IV alcohol dehydrogenase genes in developing epithelia suggest a role for alcohol dehydrogenase in local retinoic acid synthesis

1 reference

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7 January 2021

Regional Restriction of Alcohol/Retinol Dehydrogenases along the Mouse Gastrointestinal Epithelium

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Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase Adh3

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Metabolic deficiencies in alcohol dehydrogenase Adh1, Adh3, and Adh4 null mutant mice. Overlapping roles of Adh1 and Adh4 in ethanol clearance and metabolism of retinol to retinoic acid

1 reference

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Impaired retinol utilization in Adh4 alcohol dehydrogenase mutant mice

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Excessive vitamin A toxicity in mice genetically deficient in either alcohol dehydrogenase Adh1 or Adh3

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Distinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant mice

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Aberrant growth plate development in VDR/RXR gamma double null mutant mice.

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The identification of a 9-cis retinol dehydrogenase in the mouse embryo reveals a pathway for synthesis of 9-cis retinoic acid.

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The visual cycle retinol dehydrogenase: possible involvement in the 9-cis retinoic acid biosynthetic pathway

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cDNA Cloning and Characterization of a cis-Retinol/3α-Hydroxysterol Short-chain Dehydrogenase

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cDNA cloning, tissue distribution, and substrate characteristics of a cis-Retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme

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Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal

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Disruption of the 11-cis-retinol dehydrogenase gene leads to accumulation of cis-retinols and cis-retinyl esters

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Mutations in the gene encoding 11-cis retinol dehydrogenase cause delayed dark adaptation and fundus albipunctatus

1 reference

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Retinoic acid biosynthetic enzyme ALDH1 localizes in a subset of retinoid-dependent tissues duringXenopus development

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7 January 2021

Stimulation of premature retinoic acid synthesis in Xenopus embryos following premature expression of aldehyde dehydrogenase ALDH1.

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7 January 2021

Molecular identification of a major retinoic-acid-synthesizing enzyme, a retinaldehyde-specific dehydrogenase

1 reference

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TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3

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Complementary domains of retinoic acid production and degradation in the early chick embryo

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Molecular Cloning, Genomic Organization, and Chromosomal Localization of an Additional Human Aldehyde Dehydrogenase Gene, ALDH6

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7 January 2021

Changing Patterns of the Retinoic Acid System in the Developing Retina

1 reference

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Molecular characterization of a mouse short chain dehydrogenase/reductase active with all-trans-retinol in intact cells, mRDH1

1 reference

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The alcohol dehydrogenase system

1 reference

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7 January 2021

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10.1016/S0009-2797(02)00204-1

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

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