(Q35066712)

6 August 2017

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title

p53-dependent cell death signaling in neurons (English)

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6 August 2017

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Richard S Morrison

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6 August 2017

Yoshito Kinoshita

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6 August 2017

Mark D Johnson

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6 August 2017

Weiqun Guo

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6 August 2017

Gwenn A Garden

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6 August 2017

publication date

1 January 2003

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6 August 2017

published in

Neurochemical Research

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6 August 2017

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6 August 2017

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6 August 2017

page(s)

15-27

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Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus

6 August 2017

cites work

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12 December 2020

Absence of p53: no effect in a transgenic mouse model of familial amyotrophic lateral sclerosis

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12 December 2020

Bax promotes neuronal cell death and is downregulated during the development of the nervous system.

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12 December 2020

A model for p53-induced apoptosis

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12 December 2020

Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression

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12 December 2020

Identification of a p53-dependent negative response element in the bcl-2 gene

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12 December 2020

p53-induced apoptosis as a safeguard against cancer.

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12 December 2020

Changes in c-Jun but not Bcl-2 family proteins in p53-dependent apoptosis of mouse cerebellar granule neurons induced by DNA damaging agent bleomycin

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12 December 2020

Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice

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12 December 2020

Kainic acid-induced apoptosis in rat striatum is associated with nuclear factor-kappaB activation

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12 December 2020

p53 facilitates pRb cleavage in IL-3-deprived cells: novel pro-apoptotic activity of p53.

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12 December 2020

The insulin-like growth factor I receptor as a physiologically relevant target of p53 in apoptosis caused by interleukin-3 withdrawal.

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12 December 2020

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

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12 December 2020

Identification and classification of p53-regulated genes

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12 December 2020

Attenuation of p53 expression protects against focal ischemic damage in transgenic mice

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12 December 2020

p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2.

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12 December 2020

Organelle-specific initiation of cell death pathways

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12 December 2020

Inhibition of HIV-1 gp120-induced apoptosis in neuroblastoma SK-N-SH cells by an antisense oligodeoxynucleotide against p53.

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12 December 2020

Necrosis and apoptosis after retinal ischemia: involvement of NMDA-mediated excitotoxicity and p53

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12 December 2020

Cyclin-dependent kinases and P53 pathways are activated independently and mediate Bax activation in neurons after DNA damage.

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12 December 2020

Mitochondrial permeability transition is a central coordinating event of apoptosis

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12 December 2020

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

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12 December 2020

Role of NF-κB in p53-mediated programmed cell death

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12 December 2020

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

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12 December 2020

Oncogene-dependent regulation of caspase activation by p53 protein in a cell-free system

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12 December 2020

APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death.

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12 December 2020

Motor neuron cell death in a mouse model of FALS is not mediated by the p53 cell survival regulator.

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12 December 2020

Regulation of neuronal survival by the serine-threonine protein kinase Akt

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12 December 2020

The tumor-suppressor gene, p53, is induced in injured brain regions following experimental traumatic brain injury

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12 December 2020

Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death

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12 December 2020

Bax Involvement in p53-Mediated Neuronal Cell Death

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12 December 2020

p53-deficient mice are protected against adrenalectomy-induced apoptosis.

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12 December 2020

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

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12 December 2020

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

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12 December 2020

The involvement of p53 in dopamine-induced apoptosis of cerebellar granule neurons and leukemic cells overexpressing p53.

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12 December 2020

Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

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12 December 2020

Perturbed endoplasmic reticulum function, synaptic apoptosis and the pathogenesis of Alzheimer's disease.

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12 December 2020

Drosophila p53 binds a damage response element at the reaper locus

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12 December 2020

Neuroprotective effects of chronic lithium on focal cerebral ischemia in rats

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12 December 2020

Nuclear factor kappaB nuclear translocation upregulates c-Myc and p53 expression during NMDA receptor-mediated apoptosis in rat striatum

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12 December 2020

Neurons from mouse embryos with a null mutation in the tumour suppressor gene p53 undergo normal cell death in the absence of neurotrophins

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12 December 2020

Nuclear accumulation of p53 protein following kainic acid-induced seizures.

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12 December 2020

Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation.

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12 December 2020

Neurons are protected from excitotoxic death by p53 antisense oligonucleotides delivered in anionic liposomes

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12 December 2020

Reduction of Purkinje cell pathology in SCA1 transgenic mice by p53 deletion

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12 December 2020

Postinjury magnesium treatment attenuates traumatic brain injury-induced cortical induction of p53 mRNA in rats

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12 December 2020

Wild-type p53 negatively regulates the expression of a microtubule-associated protein

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12 December 2020

Status epilepticus induces p53 sequence-specific DNA binding in mature rat brain.

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12 December 2020

Activated phosphatidylinositol 3-kinase and Akt kinase promote survival of superior cervical neurons

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12 December 2020

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

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12 December 2020

Neuronal cell death in Down's syndrome

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12 December 2020

p53, the cellular gatekeeper for growth and division

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12 December 2020

The complexity of p53 modulation: emerging patterns from divergent signals

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12 December 2020

p53 expression in brain after middle cerebral artery occlusion in the rat

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12 December 2020

The tumor suppressor p53 and its response gene p21WAF1/Cip1 are not markers of neuronal death following transient global cerebral ischemia

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12 December 2020

The p53 targets mdm2 and Fas are not required as mediators of apoptosis in vivo

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12 December 2020

p53 involves cytosine arabinoside-induced apoptosis in cultured cerebellar granule neurons

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12 December 2020

Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest

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12 December 2020

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

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12 December 2020

p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats

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12 December 2020

BAX translocation is a critical event in neuronal apoptosis: regulation by neuroprotectants, BCL-2, and caspases

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12 December 2020

Induction of the growth inhibitor IGF-binding protein 3 by p53

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12 December 2020

Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53.

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12 December 2020

Endogenous bax translocation in SH-SY5Y human neuroblastoma cells and cerebellar granule neurons undergoing apoptosis

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12 December 2020

Co-stimulation of cyclic-AMP-linked metabotropic glutamate receptors in rat striatum attenuates excitotoxin-induced nuclear factor-kappaB activation and apoptosis

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12 December 2020

Cerebellar neurodegeneration in human hereditary DNA repair disorders

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12 December 2020

p53 in signaling checkpoint arrest or apoptosis

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12 December 2020

Commitment to apoptosis is associated with changes in mitochondrial biogenesis and activity in cell lines conditionally immortalized with simian virus 40.

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12 December 2020

Bcl-X(L)-caspase-9 interactions in the developing nervous system: evidence for multiple death pathways

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12 December 2020

The role of free radicals and p53 in neuron apoptosis in vivo

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12 December 2020

Sympathetic neuron survival and proliferation are prolonged by loss of p53 and neurofibromin

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12 December 2020

p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis

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12 December 2020

Evidence for involvement of Bax and p53, but not caspases, in radiation-induced cell death of cultured postnatal hippocampal neurons

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12 December 2020

Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis

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12 December 2020

15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis

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12 December 2020

P53- and CD95-associated apoptosis in neurodegenerative diseases

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12 December 2020

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

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12 December 2020

MEKK1/JNK signaling stabilizes and activates p53.

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12 December 2020

Tumor suppressor p53 induction and DNA damage in hippocampal granule cells after adrenalectomy.

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12 December 2020

Changes of p53 in the brains of patients with Alzheimer's disease

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12 December 2020

Injury-induced apoptosis of neurons in adult brain is mediated by p53-dependent and p53-independent pathways and requires Bax.

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12 December 2020

p53 protein in sympathetic neurons: cytoplasmic localization and no apparent function in apoptosis

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12 December 2020

Bax and Bak proteins require caspase activity to trigger apoptosis in sympathetic neurons

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12 December 2020

Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system

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12 December 2020

Apoptosis-associated proteins p53 and APO-1/Fas (CD95) in brains of adult patients with Down syndrome

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12 December 2020

Ataxia telangiectasia mutated-dependent apoptosis after genotoxic stress in the developing nervous system is determined by cellular differentiation status.

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12 December 2020

p53 expression induces apoptosis in hippocampal pyramidal neuron cultures.

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12 December 2020

Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons

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12 December 2020

Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis

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12 December 2020

An anti-apoptotic role for the p53 family member, p73, during developmental neuron death

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12 December 2020

Contribution of p53-dependent caspase activation to neuronal cell death declines with neuronal maturation.

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12 December 2020

Induction of tumour-suppressor phosphoprotein p53 in the apoptosis of cultured rat cerebellar neurones triggered by excitatory amino acids.

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12 December 2020

Regulation and function of the p53-related proteins: same family, different rules

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12 December 2020

p53 induction is associated with neuronal damage in the central nervous system

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12 December 2020

Long term lithium treatment suppresses p53 and Bax expression but increases Bcl-2 expression. A prominent role in neuroprotection against excitotoxicity

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12 December 2020

Dopamine neurons from transgenic mice with a knockout of the p53 gene resist MPTP neurotoxicity

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12 December 2020

Peg3/Pw1 promotes p53-mediated apoptosis by inducing Bax translocation from cytosol to mitochondria

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12 December 2020

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

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12 December 2020

Hypoxia-induced apoptosis: effect of hypoxic severity and role of p53 in neuronal cell death

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12 December 2020

Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system

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12 December 2020

Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor

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12 December 2020

p53 and Bax activation in 6-hydroxydopamine-induced apoptosis in PC12 cells

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12 December 2020

Involvement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and p53 in neuronal apoptosis: evidence that GAPDH is upregulated by p53

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12 December 2020

ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation

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12 December 2020

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

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12 December 2020

p53: puzzle and paradigm

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12 December 2020

Involvement of p53 in DNA strand break-induced apoptosis in postmitotic CNS neurons

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12 December 2020

Differential p53 phosphorylation and activation of apoptosis-promoting genes Bax and Fas/APO-1 by irradiation and ara-C treatment

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12 December 2020

Peg3/Pw1 is involved in p53-mediated cell death pathway in brain ischemia/hypoxia

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12 December 2020

DNA damage-induced neural precursor cell apoptosis requires p53 and caspase 9 but neither Bax nor caspase 3

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12 December 2020

Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis

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12 December 2020

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

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12 December 2020

A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.

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12 December 2020

Increase in p53 protein expression following cortical infarction in the spontaneously hypertensive rat.

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12 December 2020

p53 protein at the hub of cellular DNA damage response pathways through sequence-specific and non-sequence-specific DNA binding

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12 December 2020

BAX is required for neuronal death after trophic factor deprivation and during development

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12 December 2020

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12 December 2020

Analyses of p53 target genes in the human genome by bioinformatic and microarray approaches

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12 December 2020

Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53.

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12 December 2020

p53 is essential for developmental neuron death as regulated by the TrkA and p75 neurotrophin receptors

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12 December 2020

Apoptosis and expression of p53 response proteins and cyclin D1 after cortical impact in rat brain

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12 December 2020

DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

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12 December 2020

Photochemical brain injury in rats triggers DNA fragmentation, p53 and HSP72

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12 December 2020

Ras regulates sympathetic neuron survival by suppressing the p53-mediated cell death pathway

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12 December 2020

A role for MAPK/ERK in sympathetic neuron survival: protection against a p53-dependent, JNK-independent induction of apoptosis by cytosine arabinoside.

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12 December 2020

p53 is abnormally elevated and active in the CNS of patients with amyotrophic lateral sclerosis

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12 December 2020

Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system

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12 December 2020

Genetic determinants of susceptibility to excitotoxic cell death: implications for gene targeting approaches

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12 December 2020

p53‐Knockout Mice Are Protected Against the Long‐Term Effects of Methamphetamine on Dopaminergic Terminals and Cell Bodies

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12 December 2020

Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons

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12 December 2020

Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis

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12 December 2020

A conserved intronic response element mediates direct p53-dependent transcriptional activation of both the human and murine bax genes

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12 December 2020

PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family

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12 December 2020

p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons

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12 December 2020

Three distinct signalling responses by murine fibroblasts to genotoxic stress

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12 December 2020

Evidence for p53-mediated modulation of neuronal viability.

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12 December 2020

Differential induction of p53 in immature and adult rat brain following lithium-pilocarpine status epilepticus

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12 December 2020

Excitotoxic lesion of rat brain with quinolinic acid induces expression of p53 messenger RNA and protein and p53-inducible genes Bax and Gadd-45 in brain areas showing DNA fragmentation

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12 December 2020

Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease

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12 December 2020

The p53/p63/p73 family of transcription factors: overlapping and distinct functions.

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12 December 2020

Differential involvement of MEK kinase 1 (MEKK1) in the induction of apoptosis in response to microtubule-targeted drugs versus DNA damaging agents

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12 December 2020

BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases

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12 December 2020

p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release.

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12 December 2020

Identifiers

DOI

10.1023/A:1021687810103

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Dimensions Publication ID

6 August 2017

1047047925

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