(Q35058522)

6 August 2017

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title

Tor signalling in bugs, brain and brawn (English)

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6 August 2017

Estela Jacinto

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6 August 2017

Michael N Hall

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6 August 2017

publication date

1 February 2003

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Nature Reviews Molecular Cell Biology

6 August 2017

published in

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6 August 2017

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6 August 2017

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6 August 2017

page(s)

117-126

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Protean PTEN: form and function

6 August 2017

cites work

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Tuberous sclerosis complex genes: from flies to human genetics

21 January 2018

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Oncogenic kinase signalling

21 January 2018

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Size control in animal development

21 January 2018

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TOR, a central controller of cell growth

21 January 2018

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Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

21 January 2018

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Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

21 January 2018

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TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast

21 January 2018

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The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine

21 January 2018

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Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans

21 January 2018

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Expression and disruption of the Arabidopsis TOR (target of rapamycin) gene

21 January 2018

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TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation

21 January 2018

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Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin

21 January 2018

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Regulation of cellular growth by the Drosophila target of rapamycin dTOR

21 January 2018

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A mammalian protein targeted by G1-arresting rapamycin-receptor complex

21 January 2018

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RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

21 January 2018

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RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex

21 January 2018

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21 January 2018

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Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

21 January 2018

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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

21 January 2018

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Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro

21 January 2018

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HEAT repeats in the Huntington's disease protein

21 January 2018

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FAT: a novel domain in PIK-related kinases

21 January 2018

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Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

21 January 2018

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RTG-dependent mitochondria to nucleus signaling is negatively regulated by the seven WD-repeat protein Lst8p

21 January 2018

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

21 January 2018

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

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Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

21 January 2018

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

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Akt regulates growth by directly phosphorylating Tsc2

21 January 2018

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TOR controls translation initiation and early G1 progression in yeast

21 January 2018

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TOR2 is required for organization of the actin cytoskeleton in yeast

21 January 2018

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The TOR signaling cascade regulates gene expression in response to nutrients

21 January 2018

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Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins

21 January 2018

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Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae

21 January 2018

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Rapamycin induces the G0 program of transcriptional repression in yeast by interfering with the TOR signaling pathway

21 January 2018

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Tor-mediated induction of autophagy via an Apg1 protein kinase complex

21 January 2018

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Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast

21 January 2018

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The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease

21 January 2018

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Starvation induces vacuolar targeting and degradation of the tryptophan permease in yeast

21 January 2018

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Regulation of translational effectors by amino acid and mammalian target of rapamycin signaling pathways. Possible involvement of autophagy in cultured hepatoma cells

21 January 2018

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Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake

21 January 2018

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The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors

21 January 2018

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The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine

21 January 2018

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Mks1 in concert with TOR signaling negatively regulates RTG target gene expression in S. cerevisiae

21 January 2018

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RTG-dependent mitochondria-to-nucleus signaling is regulated by MKS1 and is linked to formation of yeast prion [URE3]

21 January 2018

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Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

21 January 2018

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An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

21 January 2018

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Regulation of translation initiation by FRAP/mTOR

21 January 2018

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3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

21 January 2018

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Phosphorylation and activation of p70s6k by PDK1

21 January 2018

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Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

21 January 2018

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Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

21 January 2018

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Mammalian TOR: a homeostatic ATP sensor

21 January 2018

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Phosphatidic acid-mediated mitogenic activation of mTOR signaling

21 January 2018

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Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

21 January 2018

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Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

21 January 2018

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Amino acid availability regulates p70 S6 kinase and multiple translation factors

21 January 2018

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Identification of TOR signaling complexes: more TORC for the cell growth engine

21 January 2018

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Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic beta-cells

21 January 2018

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The SAP, a new family of proteins, associate and function positively with the SIT4 phosphatase

21 January 2018

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The SIT4 protein phosphatase functions in late G1 for progression into S phase

21 January 2018

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Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases

21 January 2018

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Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast

21 January 2018

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TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway

21 January 2018

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Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

21 January 2018

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B cell receptor-associated protein α4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A

21 January 2018

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MID1, mutated in Opitz syndrome, encodes an ubiquitin ligase that targets phosphatase 2A for degradation

21 January 2018

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Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4.

21 January 2018

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Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2

21 January 2018

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Why size matters: altering cell size

21 January 2018

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Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4.

21 January 2018

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PDK1 regulates growth through Akt and S6K in Drosophila

21 January 2018

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Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB.

21 January 2018

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Drosophila S6 kinase: a regulator of cell size

21 January 2018

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Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

21 January 2018

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Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

21 January 2018

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The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

21 January 2018

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The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila

21 January 2018

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Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways.

21 January 2018

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Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

21 January 2018

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IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1.

21 January 2018

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Skeletal muscle hypertrophy is mediated by a Ca2+-dependent calcineurin signalling pathway

21 January 2018

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A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification

21 January 2018

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Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load

21 January 2018

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Akt/protein kinase B promotes organ growth in transgenic mice

21 January 2018

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Synapse-Specific, Long-Term Facilitation of Aplysia Sensory to Motor Synapses: A Function for Local Protein Synthesis in Memory Storage

21 January 2018

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A transient, neuron-wide form of CREB-mediated long-term facilitation can be stabilized at specific synapses by local protein synthesis.

21 January 2018

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A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus

21 January 2018

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Brain-derived neurotrophic factor enhances neuronal translation by activating multiple initiation processes: comparison with the effects of insulin

21 January 2018

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The phosphoinositide 3-kinase and p70 S6 kinase regulate long-term potentiation in hippocampal neurons

21 January 2018

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PTEN function in mammalian cell size regulation

21 January 2018

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Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

21 January 2018

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Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice

21 January 2018

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Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

21 January 2018

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Bench to bedside: the development of rapamycin and its application to stent restenosis

21 January 2018

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Nitrogen regulation in Saccharomyces cerevisiae

21 January 2018

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Sensors of extracellular nutrients in Saccharomyces cerevisiae

21 January 2018

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Glucose-sensing mechanisms in eukaryotic cells.

21 January 2018

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Calcineurin signaling and muscle remodeling

21 January 2018

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The molecular biology of memory storage: a dialogue between genes and synapses

21 January 2018

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Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes

21 January 2018

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Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins

31 March 2020

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Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling

31 March 2020

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Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway

31 March 2020

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Protein phosphatase 2A: who shall regulate the regulator?

31 March 2020

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The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

31 March 2020

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Phosphorylation of p70(S6k) correlates with increased skeletal muscle mass following resistance exercise

31 March 2020

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Serotonin activates S6 kinase in a rapamycin-sensitive manner in Aplysia synaptosomes.

31 March 2020

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The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses

31 March 2020

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Myogenic satellite cells: physiology to molecular biology

31 March 2020

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Mechanism of metabolic control. Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRM1018

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6 August 2017

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