(Q35040174)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12516522%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

review article

1 reference

title

Discovery of CEP-1347/KT-7515, an inhibitor of the JNK/SAPK pathway for the treatment of neurodegenerative diseases (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12516522%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

1 reference

Michael S Saporito

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12516522%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

Robert L Hudkins

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12516522%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

Anna C Maroney

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12516522%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

publication date

1 January 2002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12516522%20AND%20SRC:MED&resulttype=core&format=json

Progress in medicinal chemistry

16 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12516522%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12516522%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

page(s)

23-62

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12516522%20AND%20SRC:MED&resulttype=core&format=json

Apoptosis in the pathogenesis and treatment of disease

16 December 2019

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7 January 2021

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7 January 2021

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7 January 2021

The role of Jun transcription factor expression and phosphorylation in neuronal differentiation, neuronal cell death, and plastic adaptations in vivo

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7 January 2021

A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death

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7 January 2021

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

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7 January 2021

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

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7 January 2021

The stress-activated protein kinase subfamily of c-Jun kinases

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7 January 2021

Phosphorylation of c-Jun Is Necessary for Apoptosis Induced by Survival Signal Withdrawal in Cerebellar Granule Neurons

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7 January 2021

Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death

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7 January 2021

Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

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7 January 2021

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

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7 January 2021

Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2

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7 January 2021

SKK4, a novel activator of stress‐activated protein kinase‐1 (SAPK1/JNK)

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7 January 2021

Identification of c-Jun NH2-terminal Protein Kinase (JNK)-activating Kinase 2 as an Activator of JNK but Not p38

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7 January 2021

Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase

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7 January 2021

Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase

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7 January 2021

Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli

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7 January 2021

The stress-activated protein kinase pathways

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7 January 2021

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

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7 January 2021

Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal kinase pathway and apoptosis in sympathetic neurons

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7 January 2021

Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family

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7 January 2021

The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death

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7 January 2021

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

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7 January 2021

Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation

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7 January 2021

Induction of c-Jun and suppression of CREB transcription factor proteins in axotomized neurons of substantia nigra and covariation with tyrosine hydroxylase

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7 January 2021

Transection of rat fimbria-fornix induces lasting expression of c-Jun protein in axotomized septal neurons immunonegative for choline acetyltransferase and nitric oxide synthase

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7 January 2021

Strong c-Jun/AP-1 immunoreactivity is restricted to apoptotic cells following intracerebral ibotenic acid injection in developing rats

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7 January 2021

c-jun expression in substantia nigra neurons following striatal 6-hydroxydopamine lesions in the rat.

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7 January 2021

Medial septal cholinergic neurons express c-Jun but do not undergo DNA fragmentation after fornix-fimbria transections

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7 January 2021

Selective expression of Jun proteins following axotomy and axonal transport block in peripheral nerves in the rat: evidence for a role in the regeneration process

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7 January 2021

The differential control of c-jun expression in regenerating sensory neurons and their associated glial cells

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7 January 2021

Immediate-early gene protein expression in neurons undergoing delayed death, but not necrosis, following hypoxic-ischaemic injury to the young rat brain

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7 January 2021

Activity and expression of JNK1, p38 and ERK kinases, c-Jun N-terminal phosphorylation, and c-jun promoter binding in the adult rat brain following kainate-induced seizures

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7 January 2021

Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury.

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7 January 2021

Defective T Cell Differentiation in the Absence of Jnk1

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7 January 2021

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7 January 2021

The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development

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7 January 2021

DNA damage and apoptosis in Alzheimer's disease: colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay.

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7 January 2021

K-252a, a potent inhibitor of protein kinase C from microbial origin

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7 January 2021

K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases

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7 January 2021

K-252a induces tyrosine phosphorylation of the focal adhesion kinase and neurite outgrowth in human neuroblastoma SH-SY5Y cells.

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7 January 2021

Differential effects of the protein kinase inhibitor K-252a on the in vitro survival of chick embryonic neurons

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7 January 2021

K-252a and staurosporine promote choline acetyltransferase activity in rat spinal cord cultures

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7 January 2021

Staurosporine, K-252a, and K-252b stabilize calcium homeostasis and promote survival of CNS neurons in the absence of glucose.

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7 January 2021

Staurosporine and K-252 compounds protect hippocampal neurons against amyloid beta-peptide toxicity and oxidative injury

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7 January 2021

Inhibition by K-252a, a new inhibitor of protein kinase, of nerve growth factor-induced neurite outgrowth of chick embryo dorsal root ganglion cells

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7 January 2021

K-252a, a potent protein kinase inhibitor, blocks nerve growth factor-induced neurite outgrowth and changes in the phosphorylation of proteins in PC12h cells

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7 January 2021

Inhibition of the cellular actions of nerve growth factor by staurosporine and K252A results from the attenuation of the activity of the trk tyrosine kinase

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7 January 2021

Specific inhibition of NGF receptor tyrosine kinase activity by K-252a

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7 January 2021

K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses

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7 January 2021

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7 January 2021

Enzyme-linked immunosorbent assay for trkA tyrosine kinase activity

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7 January 2021

CEP-1347/KT7515, a JNK pathway inhibitor, supports the in vitro survival of chick embryonic neurons.

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7 January 2021

Motoneuron Apoptosis Is Blocked by CEP-1347 (KT 7515), a Novel Inhibitor of the JNK Signaling Pathway

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7 January 2021

Skeletal muscle-derived trophic factors prevent motoneurons from entering an active cell death program in vitro.

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7 January 2021

Motoneurons deprived of trophic support in vitro require new gene expression to undergo programmed cell death

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7 January 2021

Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines

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7 January 2021

Members of several gene families influence survival of rat motoneurons in vitro and in vivo.

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7 January 2021

Neurotrophins promote motor neuron survival and are present in embryonic limb bud.

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7 January 2021

GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle

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7 January 2021

Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors

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7 January 2021

The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat

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7 January 2021

Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

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7 January 2021

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

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7 January 2021

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

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7 January 2021

Oxidative stress, glutamate, and neurodegenerative disorders

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7 January 2021

Oxidative stress in Parkinson's disease

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7 January 2021

Multiple Pathways of Neuronal Death Induced by DNA-Damaging Agents, NGF Deprivation, and Oxidative Stress

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7 January 2021

Role of mitogen-activated protein kinase phosphatase during the cellular response to genotoxic stress. Inhibition of c-Jun N-terminal kinase activity and AP-1-dependent gene activation

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7 January 2021

The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation

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7 January 2021

The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation

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7 January 2021

Nedd2 is required for apoptosis after trophic factor withdrawal, but not superoxide dismutase (SOD1) downregulation, in sympathetic neurons and PC12 cells

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7 January 2021

Activation-induced apoptosis in lymphocytes.

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7 January 2021

Fibroblast growth factor-2 suppression of tumor necrosis factor alpha-mediated apoptosis requires Ras and the activation of mitogen-activated protein kinase

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7 January 2021

Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

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7 January 2021

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.

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7 January 2021

Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosis

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7 January 2021

Cell death of motoneurons in the chick embryo spinal cord. I. A light and electron microscopic study of naturally occurring and induced cell loss during development

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7 January 2021

Androgens prevent normally occurring cell death in a sexually dimorphic spinal nucleus.

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7 January 2021

The cholinergic hypothesis of geriatric memory dysfunction

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7 January 2021

The basal forebrain-cortical cholinergic system: interpreting the functional consequences of excitotoxic lesions

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7 January 2021

The organization and some projections of cholinergic neurons of the mammalian forebrain.

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7 January 2021

Cholinergic mechanisms in learning, memory and dementia: a review of recent evidence

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7 January 2021

Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain

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7 January 2021

On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis

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7 January 2021

Spatial learning in rats: correlation with cortical choline acetyltransferase and improvement with NGF following NBM damage

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7 January 2021

Widespread neuronal degeneration after ibotenic acid lesioning of cholinergic neurons in the nucleus basalis revealed by in situ hybridization

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7 January 2021

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

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7 January 2021

Preservation of cholinergic activity and prevention of neuron death by CEP-1347/KT-7515 following excitotoxic injury of the nucleus basalis magnocellularis.

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7 January 2021

Cholinergic projections from the basal forebrain to the basolateral amygdaloid complex: a combined retrograde fluorescent and immunohistochemical study

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7 January 2021

Attentional functions of the forebrain cholinergic systems: effects of intraventricular hemicholinium, physostigmine, basal forebrain lesions and intracortical grafts on a multiple-choice serial reaction time task

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7 January 2021

AMPA-induced excitotoxic lesions of the basal forebrain: a significant role for the cortical cholinergic system in attentional function.

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7 January 2021

Behavioural, histochemical and biochemical consequences of selective immunolesions in discrete regions of the basal forebrain cholinergic system

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7 January 2021

Prediction of probable Alzheimer's disease in memory-impaired patients: A prospective longitudinal study

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7 January 2021

Effect of delayed treatment with nerve growth factor on choline acetyltransferase activity in the cortex of rats with lesions of the nucleus basalis magnocellularis: dose requirements

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7 January 2021

Grafting of nerve growth factor-producing fibroblasts reduces behavioral deficits in rats with lesions of the nucleus basalis magnocellularis

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7 January 2021

Attenuation of nucleus basalis of Meynert lesion-induced cholinergic deficits by nerve growth factor

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7 January 2021

Differential modulation of the cholinergic phenotype of the nucleus basalis magnocellularis neurons by applying NGF at the cell body or cortical terminal fields

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7 January 2021

Chronic sparing of delayed alternation performance and choline acetyltransferase activity by CEP-1347/KT-7515 in rats with lesions of nucleus basalis magnocellularis

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7 January 2021

Morphological response of axotomized septal neurons to nerve growth factor

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7 January 2021

Recombinant human nerve growth factor prevents retrograde degeneration of axotomized basal forebrain cholinergic neurons in the rat.

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7 January 2021

CEP-1347 increases ChAT activity in culture and promotes cholinergic neurone survival following fimbria-fornix lesion

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7 January 2021

Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain

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7 January 2021

Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections

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7 January 2021

Parkinson's disease: pathophysiology

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7 January 2021

The etiology of Parkinson's disease with emphasis on the MPTP story

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

The rationale for the use of dopamine agonists in Parkinson's disease

1 reference

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7 January 2021

Dopamine receptors--physiological understanding to therapeutic intervention potential

1 reference

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7 January 2021

Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Chronic exposure to MPTP as a primate model of progressive parkinsonism: a pilot study with a free radical scavenger

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970081-X

7 January 2021

Studies on the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: inhibition of NAD-linked substrate oxidation by its metabolite, 1-methyl-4-phenylpyridinium

1 reference

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7 January 2021

Mitochondria in the etiology and pathogenesis of parkinson's disease

1 reference

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7 January 2021

Origin and functional consequences of the complex I defect in Parkinson's disease

1 reference

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7 January 2021

Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons

1 reference

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7 January 2021

Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: relevance to Parkinson's disease

1 reference

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7 January 2021

Apoptosis is induced by 1-methyl-4-phenylpyridinium ion (MPP+) in ventral mesencephalic-striatal co-culture in rat.

1 reference

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7 January 2021

In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining

1 reference

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7 January 2021

Characterization and time course of MPP+ -induced apoptosis in human SH-SY5Y neuroblastoma cells

1 reference

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7 January 2021

Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine neurotoxicity

1 reference

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7 January 2021

Dopamine neurons from transgenic mice with a knockout of the p53 gene resist MPTP neurotoxicity

1 reference

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7 January 2021

Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with parkinson disease

1 reference

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7 January 2021

MPTP activates c-Jun NH(2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo

1 reference

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7 January 2021

In vivo intracerebral microdialysis studies in rats of MPP+ analogues and related charged species

1 reference

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7 January 2021

Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease

1 reference

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7 January 2021

Rapid ATP loss caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mouse brain

1 reference

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7 January 2021

Striatal MPP+ levels do not necessarily correlate with striatal dopamine levels after MPTP treatment in mice

1 reference

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7 January 2021

Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation

1 reference

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7 January 2021

Stress-activated protein kinase/c-jun N-terminal kinase phosphorylates tau protein

1 reference

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7 January 2021

K-252 compounds: modulators of neurotrophin signal transduction

1 reference

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7 January 2021

Animal models of Alzheimer's disease: experimental cholinergic denervation

1 reference

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7 January 2021

Human brain cholinergic pathways

1 reference

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7 January 2021

Pilocarpine and physostigmine attenuate spatial memory impairments produced by lesions of the nucleus basalis magnocellularis

1 reference

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7 January 2021

Basal forebrain neurons and memory: A biochemical, histological, and behavioral study of differential vulnerability to ibotenate and quisqualate

1 reference

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7 January 2021

Behavioral vigilance following infusions of 192 IgG-saporin into the basal forebrain: selectivity of the behavioral impairment and relation to cortical AChE-positive fiber density

1 reference

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7 January 2021

Light deprivation accelerates recovery from frontal cortical neglect: relation to locomotion and striatal Fos expression

1 reference

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7 January 2021

10.1016/S0079-6468(08)70081-X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12516522%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12516522%20AND%20SRC:MED&resulttype=core&format=json