(Q34972949)

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Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3

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Europe PubMed Central

PubMed publication ID

5 August 2017

Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3 (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

author name string

Rehan Ahmad

1

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Deepak Raina

2

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Colin Meyer

3

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Donald Kufe

4

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

language of work or name

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publication date

1 April 2008

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Cancer Research

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Europe PubMed Central

PubMed publication ID

5 August 2017

68

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

2920-2926

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

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1 reference

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Touched and moved by STAT3.

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2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer

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A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

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Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

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Triterpenoid CDDO-Im downregulates PML/RARalpha expression in acute promyelocytic leukemia cells.

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c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells.

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A STAT3 dimer formed by inter-chain disulphide bridging during oxidative stress.

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Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C.

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Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling

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The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance

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Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity.

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based on heuristic

inferred from PubMed ID database lookup

The novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid induces apoptosis of human myeloid leukemia cells by a caspase-8-dependent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/18413761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/0008-5472.CAN-07-3036

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

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