(Q34948467)

5 August 2017

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title

Is thrombin a key player in the 'coagulation-atherogenesis' maze? (English)

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5 August 2017

Hugo ten Cate

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Julian Ilcheff Borissoff

series ordinal

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5 August 2017

Henri M H Spronk

series ordinal

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5 August 2017

Sylvia Heeneman

series ordinal

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5 August 2017

publication date

19 February 2009

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5 August 2017

published in

Cardiovascular Research

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5 August 2017

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5 August 2017

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5 August 2017

page(s)

392-403

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The interactions between inflammation and coagulation

5 August 2017

cites work

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Two-way interactions between inflammation and coagulation

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Mechanism of endothelium-dependent relaxation induced by thrombin in the pig coronary artery

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Heterogeneous mechanisms of endothelium-dependent relaxation for thrombin and peptide activators of protease-activated receptor-1 in porcine isolated coronary artery

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Role of the endothelium in the vascular effects of the thrombin receptor (protease-activated receptor type 1) in humans

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Thrombin causes endothelium-dependent biphasic regulation of vascular tone in the porcine renal interlobar artery

21 January 2018

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Role of protease-activated receptor-1 in endothelial nitric oxide synthase-Thr495 phosphorylation

21 January 2018

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Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells

21 January 2018

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Thrombin suppresses endothelial nitric oxide synthase and upregulates endothelin-converting enzyme-1 expression by distinct pathways: role of Rho/ROCK and mitogen-activated protein kinase

21 January 2018

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Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: implications for atherosclerotic endothelial dysfunction

21 January 2018

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Arginase activity is increased by thrombin: a mechanism for endothelial dysfunction in arterial thrombosis.

21 January 2018

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Arginase blockade lessens endothelial dysfunction after thrombosis

21 January 2018

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Upregulation of vascular arginase in hypertension decreases nitric oxide-mediated dilation of coronary arterioles

21 January 2018

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Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway

21 January 2018

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Thrombin receptor expression in normal and atherosclerotic human arteries

21 January 2018

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The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells. Comparison with the thrombin receptor

21 January 2018

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Increased expression of protease-activated receptor-2 (PAR2) and PAR4 in human coronary artery by inflammatory stimuli unveils endothelium-dependent relaxations to PAR2 and PAR4 agonists

21 January 2018

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Thrombin-induced increase in endothelial permeability is associated with changes in cell-to-cell junction organization.

21 January 2018

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ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin.

21 January 2018

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Thrombin-induced endothelial microparticle generation: identification of a novel pathway involving ROCK-II activation by caspase-2.

21 January 2018

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Role of oxidative stress in atherosclerosis

21 January 2018

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Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: Role of the p22(phox)-containing NADPH oxidase

21 January 2018

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Generation of reactive oxygen species in blood platelets.

21 January 2018

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https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

NAD(P)H oxidase: role in cardiovascular biology and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

NADPH oxidase mediates tissue factor-dependent surface procoagulant activity by thrombin in human vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Thrombin-induced p38 mitogen-activated protein kinase activation is mediated by epidermal growth factor receptor transactivation pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

The expression of the NADPH oxidase subunit p22phox is regulated by a redox-sensitive pathway in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Cloning and identification of regulatory sequences of the human thrombin receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Cyclic strain increases protease-activated receptor-1 expression in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

G protein-coupled receptor Ca2+-linked mitochondrial reactive oxygen species are essential for endothelial/leukocyte adherence

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Monocyte chemoattractant protein-1 in human atheromatous plaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Thrombin-induced expression of endothelial CX3CL1 potentiates monocyte CCL2 production and transendothelial migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Detection of up-regulated genes in thrombin-stimulated human umbilical vein endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Roles for thrombin and fibrin(ogen) in cytokine/chemokine production and macrophage adhesion in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Protease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1-dependent leukocyte recruitment in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Interleukin-6 exacerbates early atherosclerosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

The p38 mitogen-activated protein kinase pathway plays a critical role in thrombin-induced endothelial chemokine production and leukocyte recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Chemokines and cardiovascular risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

The combined role of P- and E-selectins in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

P38 MAPK: critical molecule in thrombin-induced NF-kappa B-dependent leukocyte recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Differential regulation of endothelial exocytosis of P-selectin and von Willebrand factor by protease-activated receptors and cAMP

21 January 2018

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https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Leukocyte recruitment in atherosclerosis: potential targets for therapeutic approaches?

21 January 2018

1 reference

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Thrombin and Phenotypic Modulation of the Endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

RhoA/Rho-associated kinase pathway selectively regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via activation of I kappa B kinase beta and phosphorylation of RelA/p65.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Activation of Syk by protein kinase C-delta regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via tyrosine phosphorylation of RelA/p65.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Ca(2+) signalling and PKCalpha activate increased endothelial permeability by disassembly of VE-cadherin junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Thrombin receptors activate G(o) proteins in endothelial cells to regulate intracellular calcium and cell shape changes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Involvement of Rho kinase in endothelial barrier maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Thrombin-induced endothelial barrier disruption in intact microvessels: role of RhoA/Rho kinase-myosin phosphatase axis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Differential expression and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

A dual thrombin receptor system for platelet activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Platelets in the onset of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Platelets: inflammatory firebugs of vascular walls

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

CD40 and its ligand in atherosclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Transient interaction of activated platelets with endothelial cells induces expression of monocyte-chemoattractant protein-1 via a p38 mitogen-activated protein kinase mediated pathway. Implications for atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Activated platelets mediate inflammatory signaling by regulated interleukin 1beta synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

RANTES deposition by platelets triggers monocyte arrest on inflamed and atherosclerotic endothelium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Platelet factor 4/CXCL4 induces phagocytosis and the generation of reactive oxygen metabolites in mononuclear phagocytes independently of Gi protein activation or intracellular calcium transients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Thrombin induces apoptotic events through the generation of reactive oxygen species in human platelets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Microparticles in vascular diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

The CD40/CD154 receptor/ligand dyad

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Endothelial expression of E-selectin is induced by the platelet-specific chemokine platelet factor 4 through LRP in an NF-kappaB-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Vascular effects of thrombin: involvement of NOR-1 in thrombin-induced mitogenic stimulus in vascular cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

On the mechanism of thrombin-induced angiogenesis: involvement of alphavbeta3-integrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Thrombin induces neoangiogenesis in the chick chorioallantoic membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Reactive oxygen species-sensitive p38 MAPK controls thrombin-induced migration of vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Deficiency of tissue factor pathway inhibitor promotes atherosclerosis and thrombosis in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Melagatran reduces advanced atherosclerotic lesion size and may promote plaque stability in apolipoprotein E-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Accelerated atherogenesis and neointima formation in heparin cofactor II deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Heparin cofactor II is a novel protective factor against carotid atherosclerosis in elderly individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Prothrombin fragment 1+2 is associated with carotid intima-media thickness in subjects free of clinical cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Seven haemostatic gene polymorphisms in coronary disease: meta-analysis of 66,155 cases and 91,307 controls.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Overview of hemostatic factors involved in atherosclerotic cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Statin prevents tissue factor expression in human endothelial cells: role of Rho/Rho-kinase and Akt pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Synergistic effect of sphingosine 1-phosphate on thrombin-induced tissue factor expression in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Plasminogen activator inhibitor (PAI)-1 in vascular inflammation and thrombosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Leukocytosis and ischemic vascular disease morbidity and mortality: is it time to intervene?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Leukocyte adhesion and thrombosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Blood coagulation and the risk of atherothrombosis: a complex relationship

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

Is APC activation of endothelial cell PAR1 important in severe sepsis?: No.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP066

21 January 2018

Identifiers

DOI

10.1093/CVR/CVP066

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5 August 2017

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