(Q34827173)

4 August 2017

title

Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site (English)

1 reference

4 August 2017

main subject

transmembrane protein

0 references

author name string

Gareth T Young

1 reference

4 August 2017

Ruud Zwart

1 reference

4 August 2017

Alison S Walker

1 reference

4 August 2017

Emanuele Sher

1 reference

4 August 2017

Neil S Millar

1 reference

4 August 2017

language of work or name

English

0 references

publication date

12 September 2008

1 reference

Proceedings of the National Academy of Sciences of the United States of America

4 August 2017

published in

1 reference

4 August 2017

volume

105

1 reference

4 August 2017

1 reference

4 August 2017

page(s)

14686-14691

1 reference

Identification of domains influencing assembly and ion channel properties in alpha 7 nicotinic receptor and 5-HT3 receptor subunit chimaeras.

4 August 2017

cites work

1 reference

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Nicotinic interactions with antipsychotic drugs, models of schizophrenia and impacts on cognitive function

8 July 2018

1 reference

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Allosteric modulation of nicotinic acetylcholine receptors

8 July 2018

1 reference

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Neuronal nicotinic receptors: a perspective on two decades of drug discovery research

8 July 2018

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An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo

8 July 2018

1 reference

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Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2535569

Galanthamine and Non-competitive Inhibitor Binding to ACh-binding Protein: Evidence for a Binding Site on Non-α-subunit Interfaces of Heteromeric Neuronal Nicotinic Receptors

8 July 2018

1 reference

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Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2535569

A semiempirical free energy force field with charge-based desolvation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2535569

Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2535569

Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2535569

Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2535569

Blind docking of drug-sized compounds to proteins with up to a thousand residues

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2535569

Acetylcholine nicotinic receptors: finding the putative binding site of allosteric modulators using the "blind docking" approach

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2535569

Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2535569

Allosteric mechanisms of signal transduction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2535569

A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2535569

Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2535569

Refined structure of the nicotinic acetylcholine receptor at 4A resolution

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2535569

Cys-loop receptors: new twists and turns

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2535569

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2535569

Assembly and subunit diversity of nicotinic acetylcholine receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2535569

Structure and gating mechanism of the acetylcholine receptor pore

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2535569

The diversity of subunit composition in nAChRs: evolutionary origins, physiologic and pharmacologic consequences

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2535569

Neuronal nicotinic acetylcholine receptors: from the gene to the disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2535569

Enhancement of Glycine Receptor Function by Ethanol Is Inversely Correlated with Molecular Volume at Position α267

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2535569

Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2535569

The multiple phenotypes of allosteric receptor mutants

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2535569

Evolutionary history of the ligand-gated ion-channel superfamily of receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2535569

Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2535569

A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTX

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2535569

Nicotinic receptors, allosteric proteins and medicine.

8 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0804372105

Channel opening motion of alpha7 nicotinic acetylcholine receptor as suggested by normal mode analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0804372105

Accessibility to residues in transmembrane segment four of the glycine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0804372105

Identification of binding sites in the nicotinic acetylcholine receptor for [3H]azietomidate, a photoactivatable general anesthetic

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0804372105

[3H]Benzophenone photolabeling identifies state-dependent changes in nicotinic acetylcholine receptor structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0804372105

Species selectivity of a nicotinic acetylcholine receptor agonist is conferred by two adjacent extracellular beta4 amino acids that are implicated in the coupling of binding to channel gating

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0804372105

Chimaeric nicotinic-serotonergic receptor combines distinct ligand binding and channel specificities

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2535569

Homomers of alpha 8 and alpha 7 subunits of nicotinic receptors exhibit similar channel but contrasting binding site properties

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2535569

Photoaffinity labeling of Torpedo acetylcholine receptor by physostigmine

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18791069

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Acetylcholine receptor channel imaged in the open state

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18791069

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0804372105

1 reference

4 August 2017

0 references

1 reference

4 August 2017

1 reference