(Q34802168)

4 August 2017

title

Alpha-scorpion toxin impairs a conformational change that leads to fast inactivation of muscle sodium channels (English)

1 reference

Fabiana Vasconcelos Campos

4 August 2017

author

Fabiana V Campos

0 references

Baron Chanda

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Paulo S L Beirão

1 reference

4 August 2017

Francisco Bezanilla

series ordinal

1 reference

4 August 2017

publication date

1 August 2008

1 reference

The Journal of General Physiology

4 August 2017

published in

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4 August 2017

volume

132

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4 August 2017

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4 August 2017

page(s)

251-263

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Two atomic constraints unambiguously position the S4 segment relative to S1 and S2 segments in the closed state of Shaker K channel

4 August 2017

cites work

1 reference

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Voltage-dependent displacement of the scorpion toxin Ts3 from sodium channels and its implication on the control of inactivation

8 July 2018

1 reference

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Coupling interactions between voltage sensors of the sodium channel as revealed by site-specific measurements

8 July 2018

1 reference

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Electrostatic model of S4 motion in voltage-gated ion channels

8 July 2018

1 reference

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Overview of the voltage-gated sodium channel family

8 July 2018

1 reference

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Structural basis of two-stage voltage-dependent activation in K+ channels

8 July 2018

1 reference

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Tracking voltage-dependent conformational changes in skeletal muscle sodium channel during activation.

8 July 2018

1 reference

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Molecular mechanisms of neurotoxin action on voltage-gated sodium channels.

8 July 2018

1 reference

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Immobilizing the moving parts of voltage-gated ion channels

8 July 2018

1 reference

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The voltage sensor in voltage-dependent ion channels

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483334

Movement of voltage sensor S4 in domain 4 is tightly coupled to sodium channel fast inactivation and gating charge immobilization

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483334

The Na channel voltage sensor associated with inactivation is localized to the external charged residues of domain IV, S4.

8 July 2018

1 reference

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Voltage sensors in domains III and IV, but not I and II, are immobilized by Na+ channel fast inactivation

8 July 2018

1 reference

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Structural implications of fluorescence quenching in the Shaker K+ channel

8 July 2018

1 reference

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Three transmembrane conformations and sequence-dependent displacement of the S4 domain in shaker K+ channel gating

8 July 2018

1 reference

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A specific interaction between the cardiac sodium channel and site-3 toxin anthopleurin B.

8 July 2018

1 reference

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Sodium channel inactivation is altered by substitution of voltage sensor positive charges

8 July 2018

1 reference

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Molecular determinants of high affinity binding of alpha-scorpion toxin and sea anemone toxin in the S3-S4 extracellular loop in domain IV of the Na+ channel alpha subunit

8 July 2018

1 reference

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Voltage-dependent open-state inactivation of cardiac sodium channels: gating current studies with Anthopleurin-A toxin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483334

Sodium channel mutations in paramyotonia congenita uncouple inactivation from activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483334

Gating of Shaker K+ channels: II. The components of gating currents and a model of channel activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483334

Rapid voltage-dependent dissociation of scorpion alpha-toxins coupled to Na channel inactivation in amphibian myelinated nerves

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483334

A sodium channel gating model based on single channel, macroscopic ionic, and gating currents in the squid giant axon

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483334

Membrane potential dependent binding of scorpion toxin to action potential Na+ ionophore

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483334

Activation of the action potential Na+ ionophore by neurotoxins. An allosteric model

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483334

Inactivation of the sodium channel. II. Gating current experiments

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483334

Membrane potential-dependent binding of scorpion toxin to the action potential Na+ ionophore. Studies with a toxin derivative prepared by lactoperoxidase-catalyzed iodination

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483334

Binding of scorpion and sea anemone neurotoxins to a common site related to the action potential Na+ ionophore in neuroblastoma cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483334

L-type calcium channel activation up-regulates the mRNAs for two different sodium channel alpha subunits (Nav1.2 and Nav1.3) in rat pituitary GH3 cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483334

Differential effects of homologous S4 mutations in human skeletal muscle sodium channels on deactivation gating from open and inactivated states

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483334

Tetrodotoxin reverses brevetoxin allosteric inhibition of scorpion alpha-toxin binding on rat brain sodium channels

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483334

On the slowly rising phase of the sodium gating current in the squid giant axon

26 October 2018

1 reference

12 December 2020

Effects of Bound Ts3 on Voltage Dependence of Sodium Channel Transitions to and From Inactivation and Energetics of Its Unbinding

1 reference

12 December 2020

Modulation of cloned skeletal muscle sodium channels by the scorpion toxins Lqh II, Lqh III, and Lqh alphaIT

1 reference

12 December 2020

Potential-dependent interaction of toxin from venom of the scorpion Buthus eupeus with sodium channels in myelinated fibre. Voltage clamp experiments

1 reference

12 December 2020

Structural parts involved in activation and inactivation of the sodium channel

1 reference

12 December 2020

Identifiers

DOI

10.1085/JGP.200809995

1 reference

4 August 2017

1 reference

4 August 2017

1 reference