(Q34727331)

4 August 2017

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title

Genetic approaches to the study of Toll-like receptor function (English)

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ORCID Public Data File 2021

4 August 2017

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Osamu Takeuchi

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author name string

Shizuo Akira

series ordinal

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4 August 2017

language of work or name

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1 July 2002

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4 August 2017

published in

Microbes and Infection

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4 August 2017

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4 August 2017

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4 August 2017

page(s)

887-895

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The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

4 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

The Toll-receptor family and control of innate immunity

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

A reverse genetic analysis of components of the Toll signaling pathway in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Signaling in plant-microbe interactions

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

1 reference

7 January 2021

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

A family of human receptors structurally related to Drosophila Toll

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

TLR6: A novel member of an expanding toll-like receptor family

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Innate immunity: the virtues of a nonclonal system of recognition

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guérin: involvement of toll-like receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Induction of direct antimicrobial activity through mammalian toll-like receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Co-operative induction of pro-inflammatory signaling by Toll-like receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Discrimination of bacterial lipoproteins by Toll-like receptor 6

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Human Nod1 confers responsiveness to bacterial lipopolysaccharides

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

The extra domain A of fibronectin activates Toll-like receptor 4.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Causing a commotion in the blood: immunotherapy progresses from bacteria to bacterial DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

A Toll-like receptor recognizes bacterial DNA

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Bacterial DNA-induced NK cell IFN-gamma production is dependent on macrophage secretion of IL-12

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Cloning and characterization of the murine toll-like receptor 5 (Tlr5) gene: sequence and mRNA expression studies in Salmonella-susceptible MOLF/Ei mice

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Unresponsiveness of MyD88-deficient mice to endotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Toll-like receptors control activation of adaptive immune responses

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Endotoxin-induced maturation of MyD88-deficient dendritic cells

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

TIRAP: an adapter molecule in the Toll signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2802%2901615-5

7 January 2021

10.1016/S1286-4579(02)01615-5

Identifiers

DOI

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4 August 2017

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