(Q34712326)

4 August 2017

title

TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology (English)

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4 August 2017

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Mandy J McGeachy

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4 August 2017

Kristian S Bak-Jensen

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4 August 2017

Yi Chen

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4 August 2017

Cristina M Tato

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4 August 2017

Wendy Blumenschein

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4 August 2017

Terrill McClanahan

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4 August 2017

Daniel J Cua

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4 August 2017

language of work or name

English

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publication date

11 November 2007

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4 August 2017

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4 August 2017

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4 August 2017

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4 August 2017

page(s)

1390-1397

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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

4 August 2017

cites work

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7 January 2021

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

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7 January 2021

Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation

1 reference

7 January 2021

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

1 reference

7 January 2021

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

1 reference

7 January 2021

Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17

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7 January 2021

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

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7 January 2021

Transforming growth factor-beta induces development of the T(H)17 lineage

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7 January 2021

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

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7 January 2021

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells

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7 January 2021

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system

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7 January 2021

IL-25 regulates Th17 function in autoimmune inflammation

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7 January 2021

Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation

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7 January 2021

Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid

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7 January 2021

Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease.

1 reference

7 January 2021

Mechanisms of recovery from experimental autoimmune encephalomyelitis: T cell deletion and immune deviation in myelin basic protein T cell receptor transgenic mice

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7 January 2021

Oral administration of myelin induces antigen-specific TGF-beta 1-secreting T cells in multiple sclerosis patients

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7 January 2021

Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis

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7 January 2021

Protective effect of transforming growth factor beta 1 on experimental autoimmune diseases in mice

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7 January 2021

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

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7 January 2021

IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

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7 January 2021

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

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7 January 2021

Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

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7 January 2021

A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis.

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7 January 2021

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

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7 January 2021

Chemokine expression in murine experimental allergic encephalomyelitis

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7 January 2021

Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis

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7 January 2021

Induction of macrophage-derived chemokine/CCL22 expression in experimental autoimmune encephalomyelitis and cultured microglia: implications for disease regulation

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7 January 2021

CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis

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7 January 2021

Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection.

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7 January 2021

Transgenic interleukin 10 prevents induction of experimental autoimmune encephalomyelitis

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7 January 2021

TGF-beta, a 'double agent' in the immune pathology war

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7 January 2021

IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis.

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7 January 2021

Interleukin-23 drives innate and T cell-mediated intestinal inflammation

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7 January 2021

Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology.

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7 January 2021

CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ T(H)-17 cells in relapsing EAE.

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7 January 2021

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7 January 2021

Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17

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7 January 2021

TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

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7 January 2021

Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7

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7 January 2021

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

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7 January 2021

T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation

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7 January 2021

Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system.

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7 January 2021

Suppressor T cells in human diseases

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7 January 2021

Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis

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7 January 2021

Multiple immuno-regulatory defects in type-1 diabetes

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7 January 2021

Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

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7 January 2021

Identifiers

DOI

10.1038/NI1539

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4 August 2017

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