(Q34770297)

4 August 2017

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title

p73: Friend or foe in tumorigenesis (English)

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4 August 2017

Vincenzo De Laurenzi

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Karen H Vousden

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4 August 2017

Gerry Melino

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4 August 2017

language of work or name

English

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publication date

1 August 2002

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4 August 2017

published in

Nature Reviews Cancer

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4 August 2017

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4 August 2017

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4 August 2017

page(s)

605-615

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P63 and P73: P53 mimics, menaces and more

4 August 2017

cites work

1 reference

On the shoulders of giants: p63, p73 and the rise of p53.

31 March 2020

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Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance.

31 March 2020

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Drosophila p53 binds a damage response element at the reaper locus

31 March 2020

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Drosophila p53 is a structural and functional homolog of the tumor suppressor p53.

31 March 2020

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Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

31 March 2020

1 reference

Two new p73 splice variants, gamma and delta, with different transcriptional activity.

31 March 2020

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Additional complexity in p73: induction by mitogens in lymphoid cells and identification of two new splicing variants ε and ζ

31 March 2020

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Lack of homozygously inactivated p73 in single-copy MYCN primary neuroblastomas and neuroblastoma cell lines

31 March 2020

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New p73 variants with altered C-terminal structures have varied transcriptional activities

31 March 2020

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p53 Family members p63 and p73 are SAM domain-containing proteins

31 March 2020

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Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain.

31 March 2020

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Structure and function in the p53 family

31 March 2020

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A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein

31 March 2020

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SAM as a protein interaction domain involved in developmental regulation

31 March 2020

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Oligomeric structure of the human EphB2 receptor SAM domain

31 March 2020

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p73 is a simian [correction of human] p53-related protein that can induce apoptosis

31 March 2020

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p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

31 March 2020

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An anti-apoptotic role for the p53 family member, p73, during developmental neuron death

31 March 2020

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Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53.

31 March 2020

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Transactivation-deficient Delta TA-p73 inhibits p53 by direct competition for DNA binding: implications for tumorigenesis.

31 March 2020

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Transactivation-deficient p73alpha (p73Deltaexon2) inhibits apoptosis and competes with p53.

31 March 2020

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Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter

31 March 2020

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DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest.

31 March 2020

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Human cytomegalovirus induces drug resistance and alteration of programmed cell death by accumulation of deltaN-p73alpha.

31 March 2020

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

31 March 2020

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Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

31 March 2020

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The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

31 March 2020

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Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis

31 March 2020

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p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

31 March 2020

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Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damage

31 March 2020

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Regulation of p73 by c-Abl through the p38 MAP kinase pathway.

31 March 2020

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Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo

31 March 2020

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DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes.

31 March 2020

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31 March 2020

Why is p53 acetylated?

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Role of the p53-homologue p73 in E2F1-induced apoptosis

31 March 2020

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A common E2F-1 and p73 pathway mediates cell death induced by TCR activation.

31 March 2020

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Role for the p53 homologue p73 in E2F-1-induced apoptosis

31 March 2020

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Myc requires distinct E2F activities to induce S phase and apoptosis

31 March 2020

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Physical interaction of p73 with c-Myc and MM1, a c-Myc-binding protein, and modulation of the p73 function

31 March 2020

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Mdm2 binds p73 alpha without targeting degradation

31 March 2020

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Promoter specificity and stability control of the p53-related protein p73

31 March 2020

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Inactivation of the p53-homologue p73 by the mdm2-oncoprotein

31 March 2020

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MDM2 and MDMX bind and stabilize the p53-related protein p73

31 March 2020

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MDM2 suppresses p73 function without promoting p73 degradation

31 March 2020

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MDM2 and MDMX can interact differently with ARF and members of the p53 family

31 March 2020

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The N-terminal domain of p73 interacts with the CH1 domain of p300/CREB binding protein and mediates transcriptional activation and apoptosis

31 March 2020

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C-terminal ubiquitination of p53 contributes to nuclear export

31 March 2020

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Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif

31 March 2020

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Physical interaction between Wilms tumor 1 and p73 proteins modulates their functions.

31 March 2020

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p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

31 March 2020

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Distinct regulation of p53 and p73 activity by adenovirus E1A, E1B, and E4orf6 proteins

31 March 2020

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Functional impairment of p73 and p51, the p53-related proteins, by the human T-cell leukemia virus type 1 Tax oncoprotein

31 March 2020

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Viral oncoproteins discriminate between p53 and the p53 homolog p73.

31 March 2020

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The large T antigen of simian virus 40 binds and inactivates p53 but not p73.

31 March 2020

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Adenovirus E4orf6 oncoprotein modulates the function of the p53-related protein, p73

31 March 2020

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Induction of neuronal differentiation by p73 in a neuroblastoma cell line

31 March 2020

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p63 and p73 transactivate differentiation gene promoters in human keratinocytes

31 March 2020

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Identification and classification of p53-regulated genes

31 March 2020

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p73beta, a variant of p73, enhances Wnt/beta-catenin signaling in Saos-2 cells

31 March 2020

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Overproduced p73alpha activates a minimal promoter through a mechanism independent of its transcriptional activity

31 March 2020

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Induction of p57(KIP2) expression by p73beta.

31 March 2020

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p53 family genes: structural comparison, expression and mutation

31 March 2020

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Analysis of p73 in human borderline and invasive ovarian tumor

31 March 2020

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p73 is over-expressed in vulval cancer principally as the Delta 2 isoform

31 March 2020

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DeltaN-p73alpha accumulates in human neuroblastic tumors

31 March 2020

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Expression of DeltaNp73 is a molecular marker for adverse outcome in neuroblastoma patients

31 March 2020

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Role of methylation in the control of DeltaNp73 expression in neuroblastoma

31 March 2020

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p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.

31 March 2020

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A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

31 March 2020

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Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73

31 March 2020

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A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

31 March 2020

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A common p73 polymorphism is associated with a reduced incidence of oesophageal carcinoma

31 March 2020

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p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

31 March 2020

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p63 is a p53 homologue required for limb and epidermal morphogenesis

31 March 2020

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Molecular basis for heterogeneity in human neuroblastomas

31 March 2020

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Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins

31 March 2020

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Increased Ras expression and caspase-independent neuroblastoma cell death: possible mechanism of spontaneous neuroblastoma regression

31 March 2020

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p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent

31 March 2020

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Infrequent somatic mutations of the p73 gene in various human cancers.

31 March 2020

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Analysis of p73 gene in meningiomas with deletion at 1p.

31 March 2020

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p73 is not mutated in meningiomas as determined with a functional yeast assay but p73 expression increases with tumor grade.

31 March 2020

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Mutation analysis of the p73 gene in nonastrocytic brain tumours

31 March 2020

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Loss of expression or mutations in the p73 tumour suppressor gene are not involved in the pathogenesis of malignant melanomas

31 March 2020

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Allelic loss at the p73 locus (1p36.33) is infrequent in malignant melanoma

31 March 2020

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Lack of p73 mutations and late occurrence of p73 allelic deletions in melanoma tissues and cell lines

31 March 2020

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Frequent loss of heterozygosity at 1p36.3 and p73 abnormality in parathyroid adenomas

31 March 2020

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The expression of p73 is increased in lung cancer, independent of p53 gene alteration

31 March 2020

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P73 expression in basal layers of head and neck squamous epithelium: a role in differentiation and carcinogenesis in concert with p53 and p63?

31 March 2020

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31 March 2020

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Molecular alterations of p73 in human esophageal squamous cell carcinomas: loss of heterozygosity occurs frequently; loss of imprinting and elevation of p73 expression may be related to defective p53.

31 March 2020

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Alterations of p73 preferentially occur in gastric adenocarcinomas with foveolar epithelial phenotype.

31 March 2020

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Mutation and expression analysis of the p73 gene in prostate cancer

31 March 2020

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Loss of imprinting and allele switching of p73 in renal cell carcinoma

31 March 2020

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Absence of mutation of the p73 gene localized at chromosome 1p36.3 in hepatocellular carcinoma

31 March 2020

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p73 is up-regulated in a subset of hepatocellular carcinomas

31 March 2020

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Mutational analysis of the p73 gene in human breast cancers

31 March 2020

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p73 mutations are not detected in sporadic and hereditary breast cancer

31 March 2020

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Clinicopathological characteristics of breast carcinomas with allelic loss in the p73 region

31 March 2020

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Wild type p73 overexpression and high-grade malignancy in breast cancer

31 March 2020

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Loss of heterozygosity, allele silencing and decreased expression of p73 gene in breast cancers: prevalence of alterations in inflammatory breast cancers

31 March 2020

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Allelic expression of p73 in human ovarian cancers

31 March 2020

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Frequent loss of heterozygosity at 1p36 in ovarian adenocarcinomas but the gene encoding p73 is unlikely to be the target

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC861

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Dimensions Publication ID

4 August 2017

1047430174

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