(Q34742803)

4 August 2017

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title

Apoptosis-based therapies (English)

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4 August 2017

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John C Reed

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4 August 2017

publication date

1 February 2002

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Nature Reviews Drug Discovery

4 August 2017

published in

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4 August 2017

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4 August 2017

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4 August 2017

page(s)

111-121

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Addiction modules and programmed cell death and antideath in bacterial cultures

4 August 2017

cites work

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Apoptosis in the pathogenesis and treatment of disease

31 March 2020

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31 March 2020

Mechanisms of apoptosis

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31 March 2020

Caspases: enemies within

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Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock

31 March 2020

1 reference

Defects in regulation of apoptosis in caspase-2-deficient mice

31 March 2020

1 reference

Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE.

31 March 2020

1 reference

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

31 March 2020

1 reference

Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family

31 March 2020

1 reference

Caspase inhibition reduces myocyte cell death induced by myocardial ischemia and reperfusion in vivo

31 March 2020

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Inhibition of caspase-1-like activity by Ac-Tyr-Val-Ala-Asp-chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and decrease of proinflammatory cytokines

31 March 2020

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Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model

31 March 2020

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Potent and selective nonpeptide inhibitors of caspases 3 and 7.

31 March 2020

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From bench to clinic with apoptosis-based therapeutic agents

31 March 2020

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Drug discovery opportunities from apoptosis research

31 March 2020

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Mitochondria and apoptosis

31 March 2020

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Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

31 March 2020

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Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1

31 March 2020

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An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

31 March 2020

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Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation

31 March 2020

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Caspase activation: the induced-proximity model

31 March 2020

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Differential requirement for caspase 9 in apoptotic pathways in vivo.

31 March 2020

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Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment

31 March 2020

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Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure

31 March 2020

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FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis

31 March 2020

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Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

31 March 2020

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FADD is required for DR4- and DR5-mediated apoptosis: lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts

31 March 2020

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IAP family proteins--suppressors of apoptosis

31 March 2020

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The inhibitors of apoptosis (IAPs) and their emerging role in cancer

31 March 2020

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Insights into programmed cell death through structural biology

31 March 2020

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Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

31 March 2020

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A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

31 March 2020

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ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas

31 March 2020

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Down-regulation of survivin by antisense oligonucleotides increases apoptosis, inhibits cytokinesis and anchorage-independent growth

31 March 2020

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The hippocampal neurons of neuronal apoptosis inhibitory protein 1 (NAIP1)-deleted mice display increased vulnerability to kainic acid-induced injury

31 March 2020

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Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus

31 March 2020

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Attenuation of ischemia-induced cellular and behavioral deficits by X chromosome-linked inhibitor of apoptosis protein overexpression in the rat hippocampus.

31 March 2020

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The Bcl-2 protein family: arbiters of cell survival

31 March 2020

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BCL-2 family members and the mitochondria in apoptosis

31 March 2020

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BH3-Only proteins-essential initiators of apoptotic cell death

31 March 2020

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Neonatal motoneurons overexpressing the bcl-2 protooncogene in transgenic mice are protected from axotomy-induced cell death.

31 March 2020

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Long-term survival of retinal ganglion cells following optic nerve section in adult bcl-2 transgenic mice

31 March 2020

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Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia

31 March 2020

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Bcl-2: Prolonging Life in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis

31 March 2020

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Inactivation of Bcl-2 by phosphorylation

31 March 2020

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Conversion of Bcl-2 to a Bax-like death effector by caspases

31 March 2020

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Polymer Encapsulated Cell Lines Genetically Engineered to Release Ciliary Neurotrophic Factor Can Slow Down Progressive Motor Neuronopathy in the Mouse

31 March 2020

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Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

31 March 2020

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Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

31 March 2020

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Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

31 March 2020

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Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.

31 March 2020

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Mitochondrial control of cell death

31 March 2020

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The mitochondrial permeability transition

31 March 2020

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An orally active anti-apoptotic molecule (CGP 3466B) preserves mitochondria and enhances survival in an animal model of motoneuron disease

31 March 2020

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Glyceraldehyde-3-phosphate dehydrogenase, the putative target of the antiapoptotic compounds CGP 3466 and R-(-)-deprenyl

31 March 2020

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Modulation of gene expression rather than monoamine oxidase inhibition: (-)-deprenyl-related compounds in controlling neurodegeneration

31 March 2020

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Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

31 March 2020

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Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

31 March 2020

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HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell

31 March 2020

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Death-associated proteins: from gene identification to the analysis of their apoptotic and tumour suppressive functions

31 March 2020

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Cellular survival: a play in three Akts

31 March 2020

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Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

31 March 2020

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Pathways to neuronal injury and apoptosis in HIV-associated dementia.

31 March 2020

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The multiple roles of PTEN in tumor suppression

31 March 2020

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Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1

31 March 2020

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Akt phosphorylates and regulates the orphan nuclear receptor Nur77

31 March 2020

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Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

31 March 2020

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Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains

31 March 2020

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Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

31 March 2020

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NF-kappaB signaling pathways in mammalian and insect innate immunity

31 March 2020

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NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

31 March 2020

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Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control

31 March 2020

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Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis.

31 March 2020

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Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase

31 March 2020

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Prospects for prevention and treatment of cancer with selective PPARgamma modulators (SPARMs).

31 March 2020

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Proteasome inhibition: a new strategy in cancer treatment

31 March 2020

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Estrogen withdrawal-induced human breast cancer tumour regression in nude mice is prevented by Bcl-2

31 March 2020

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Expression of Bcl-2-related genes in normal and AML progenitors: changes induced by chemotherapy and retinoic acid

31 March 2020

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Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

31 March 2020

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Role of BAX in the apoptotic response to anticancer agents

31 March 2020

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Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3.

31 March 2020

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Apoptosis. Mitochondria--the death signal integrators

31 March 2020

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Histone deacetylase inhibitors: development of suberoylanilide hydroxamic acid (SAHA) for the treatment of cancers.

31 March 2020

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Evidence for a function of CtBP in epithelial gene regulation and anoikis

31 March 2020

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An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

31 March 2020

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a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

31 March 2020

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A novel form of Epstein-Barr virus latency in normal B cells in vivo

31 March 2020

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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

31 March 2020

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PUMA, a novel proapoptotic gene, is induced by p53

31 March 2020

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PUMA induces the rapid apoptosis of colorectal cancer cells

31 March 2020

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Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression

31 March 2020

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KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

31 March 2020

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Pharmacological rescue of mutant p53 conformation and function

31 March 2020

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A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

31 March 2020

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Apoptosis control by death and decoy receptors

31 March 2020

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Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades

31 March 2020

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Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice.

31 March 2020

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Cell acidification in apoptosis: granulocyte colony-stimulating factor delays programmed cell death in neutrophils by up-regulating the vacuolar H(+)-ATPase

31 March 2020

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A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9).

31 March 2020

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Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

31 March 2020

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Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis

31 March 2020

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PML is essential for multiple apoptotic pathways

31 March 2020

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Life, death and nuclear spots

31 March 2020

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Structural basis for the inhibition of caspase-3 by XIAP

31 March 2020

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

31 March 2020

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Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

31 March 2020

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A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

31 March 2020

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A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD726

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4 August 2017

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