(Q34639829)

3 August 2017

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title

The role of c-erbB-2/HER2/neu in breast cancer progression and metastasis (English)

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3 August 2017

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Eccles SA

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3 August 2017

publication date

1 October 2001

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Journal of Mammary Gland Biology and Neoplasia

3 August 2017

published in

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3 August 2017

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3 August 2017

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3 August 2017

page(s)

393-406

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Overexpression of CD44 in pl85(neu)-transfected NIH3T3 cells promotes an up-regulation of hyaluronic acid-mediated membrane-cytoskeleton interaction and cell adhesion.

3 August 2017

cites work

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12 December 2020

Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptors

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12 December 2020

The effect of HER-2/neu overexpression on chemotherapeutic drug sensitivity in human breast and ovarian cancer cells

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12 December 2020

MCF-7 breast cancer cells overexpressing transfectedc-erbB-2 have anin vitro growth advantage in estrogen-depleted conditions and reduced estrogen-dependence and tamoxifen-sensitivityin vivo

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12 December 2020

Role of erbB2 in breast cancer chemosensitivity

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12 December 2020

ErbB2 is necessary for induction of carcinoma cell invasion by ErbB family receptor tyrosine kinases

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12 December 2020

Inhibition of focal contact formation in cells transformed by p185neu

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12 December 2020

Interactions between progestins and heregulin (HRG) signaling pathways: HRG acts as mediator of progestins proliferative effects in mouse mammary adenocarcinomas

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12 December 2020

ErbB2 overexpression on occult metastatic cells in bone marrow predicts poor clinical outcome of stage I-III breast cancer patients

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12 December 2020

Vascular endothelial growth factor up-regulation via p21-activated kinase-1 signaling regulates heregulin-beta1-mediated angiogenesis

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12 December 2020

Heregulin regulation of urokinase plasminogen activator and its receptor: human breast epithelial cell invasion

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12 December 2020

Hyperexpression of mitogen-activated protein kinase in human breast cancer

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12 December 2020

Hormonal regulation of type I receptor tyrosine kinase expression in the mammary gland

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12 December 2020

Role of HER2 gene overexpression in breast carcinoma

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12 December 2020

Heregulin regulation of autocrine motility factor expression in human tumor cells

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12 December 2020

Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells

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12 December 2020

Intraductal spread of invasive breast carcinoma has a positive correlation with c-erb B-2 overexpression and vascular invasion

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12 December 2020

HER-2 tyrosine kinase pathway targets estrogen receptor and promotes hormone-independent growth in human breast cancer cells.

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12 December 2020

c-erbB-2 positivity is a factor for poor prognosis in breast cancer and poor response to hormonal or chemotherapy treatment in advanced disease

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12 December 2020

C-erbB-2/ HER-2 upregulates fascin, an actin-bundling protein associated with cell motility, in human breast cancer cell lines

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12 December 2020

Activation (tyrosine phosphorylation) of ErbB-2 (HER-2/neu): a study of incidence and correlation with outcome in breast cancer

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12 December 2020

Muc4/sialomucin complex, an intramembrane modulator of ErbB2/HER2/Neu, potentiates primary tumor growth and suppresses apoptosis in a xenotransplanted tumor

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12 December 2020

Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase

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12 December 2020

HER2 regulatory control of angiopoietin-2 in breast cancer

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12 December 2020

Ongoing and planned trials of hormonal therapy and trastuzumab.

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12 December 2020

Multisite phosphotyping of the ErbB-2 oncoprotein in human breast cancer

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12 December 2020

Cell biology of lymphatic metastasis. The potential role of c-erbB oncogene signalling.

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12 December 2020

ERBB-2 overexpression confers PI 3' kinase-dependent invasion capacity on human mammary epithelial cells

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12 December 2020

Overexpression of ERBB2 in human mammary epithelial cells signals inhibition of transcription of the E-cadherin gene

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12 December 2020

Ligand discrimination by ErbB receptors: differential signaling through differential phosphorylation site usage

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12 December 2020

Invasive phenotype of MCF10A cells overexpressing c-Ha-ras and c-erbB-2 oncogenes.

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12 December 2020

Molecular mechanisms underlying ErbB2/HER2 action in breast cancer

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12 December 2020

Cooperative signaling between alpha(6)beta(4) integrin and ErbB-2 receptor is required to promote phosphatidylinositol 3-kinase-dependent invasion

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12 December 2020

Prognostic value of genomic alterations in minimal residual cancer cells purified from the blood of breast cancer patients

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12 December 2020

Up-regulation of vascular endothelial growth factor in breast cancer cells by the heregulin-beta1-activated p38 signaling pathway enhances endothelial cell migration.

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12 December 2020

Circulating HER2 extracellular domain and resistance to chemotherapy in advanced breast cancer.

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12 December 2020

Critical steps in hematogenous metastasis: an overview.

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12 December 2020

ERBB2 oncogene in human breast cancer and its clinical significance

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12 December 2020

Mechanisms of c-erbB2/neu oncogene-induced metastasis and repression of metastatic properties by adenovirus 5 E1A gene products

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12 December 2020

Heregulin and agonistic anti-p185(c-erbB2) antibodies inhibit proliferation but increase invasiveness of breast cancer cells that overexpress p185(c-erbB2): increased invasiveness may contribute to poor prognosis

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12 December 2020

Isolation of blood-borne epithelium-derived c-erbB-2 oncoprotein-positive clustered cells from the peripheral blood of breast cancer patients

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12 December 2020

Predicting response to adjuvant and radiation therapy in patients with early stage breast carcinoma

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12 December 2020

The role of HER-2 expression in predicting response to therapy in breast cancer

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12 December 2020

Untangling the ErbB signalling network

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12 December 2020

Enhanced sensitivity to tumor necrosis factor-alpha in doxorubicin-resistant tumor cell lines due to down-regulated c-erbB2.

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12 December 2020

Transcriptional up-regulation of paxillin expression by heregulin in human breast cancer cells

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12 December 2020

c-erbB2 expression predicts tamoxifen efficacy in breast cancer patients

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12 December 2020

Regression of established breast carcinoma xenografts with antibody-directed enzyme prodrug therapy against c-erbB2 p185

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12 December 2020

c-erbB-2/EGFR as dominant heterodimerization partners determine a motogenic phenotype in human breast cancer cells

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12 December 2020

Differential expression of alternatively spliced c-erbB-2 mRNA in primary tumors, lymph node metastases, and bone marrow micrometastases from breast cancer patients

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12 December 2020

The role of ErbB-2 tyrosine kinase receptor in cellular intrinsic chemoresistance: mechanisms and implications

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12 December 2020

Collagen-induced morphogenesis and expression of the alpha 2-integrin subunit is inhibited in c-erbB2-transfected human mammary epithelial cells.

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12 December 2020

RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion

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12 December 2020

The p185(neu)-containing glycoprotein complex of a microfilament-associated signal transduction particle. Purification, reconstitution, and molecular associations with p58(gag) and actin

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12 December 2020

Overexpression of the c-erbB-2 gene enhanced intrinsic metastasis potential in human breast cancer cells without increasing their transformation abilities

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12 December 2020

Selection of potentially metastatic subpopulations expressing c-erbB-2 from breast cancer tissue by use of an extravasation model

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12 December 2020

Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells.

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12 December 2020

Heregulin beta1-activated phosphatidylinositol 3-kinase enhances aggregation of MCF-7 breast cancer cells independent of extracellular signal-regulated kinase

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12 December 2020

c-erbB-2 as a target for immunotherapy

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12 December 2020

Overexpression of ErbB2 in cancer and ErbB2-targeting strategies

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12 December 2020

Induction of sensitivity to doxorubicin and etoposide by transfection of MCF-7 breast cancer cells with heregulin beta-2.

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12 December 2020

HER2/neu over-expression induces endothelial cell retraction

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12 December 2020

Radiosensitization of human breast cancer cells by a novel ErbB family receptor tyrosine kinase inhibitor.

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12 December 2020

Dominant negative inhibition of the association between beta-catenin and c-erbB-2 by N-terminally deleted beta-catenin suppresses the invasion and metastasis of cancer cells

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12 December 2020

Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase

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12 December 2020

Stimulation of beta1-integrin function by epidermal growth factor and heregulin-beta has distinct requirements for erbB2 but a similar dependence on phosphoinositide 3-OH kinase

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12 December 2020

Biological modifiers as potential radiosensitizers: targeting the epidermal growth factor receptor family.

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12 December 2020

The biology of human epidermal growth factor receptor 2.

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12 December 2020

Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy

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12 December 2020

Identifiers

DOI

10.1023/A:1014730829872

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Dimensions Publication ID

3 August 2017

1033015025

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