(Q34694926)

4 August 2017

title

Platforms for antibiotic discovery (English)

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4 August 2017

Kim Lewis

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4 August 2017

publication date

1 May 2013

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Nature Reviews Drug Discovery

4 August 2017

published in

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4 August 2017

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4 August 2017

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4 August 2017

page(s)

371-387

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Streptomycin, a Substance Exhibiting Antibiotic Activity Against Gram-Positive and Gram-Negative Bacteria.

4 August 2017

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ethA, inhA, and katG loci of ethionamide-resistant clinical Mycobacterium tuberculosis isolates

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Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis

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A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis

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Inhibition of synthesis of arabinogalactan by ethambutol in Mycobacterium smegmatis

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The diarylquinoline TMC207 for multidrug-resistant tuberculosis

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Antibiotics for emerging pathogens

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Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults

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A core gut microbiome in obese and lean twins

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21 January 2018

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21 January 2018

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Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation

21 January 2018

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Phage-based platforms for the clinical detection of human bacterial pathogens

21 January 2018

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Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacin

21 January 2018

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Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy

21 January 2018

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Crystal structure of bacterial multidrug efflux transporter AcrB

21 January 2018

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Structural Basis of Multiple Drug-Binding Capacity of the AcrB Multidrug Efflux Pump

21 January 2018

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The assembled structure of a complete tripartite bacterial multidrug efflux pump

21 January 2018

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

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Bacteria lacking a multidrug pump: a sensitive tool for drug discovery

21 January 2018

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Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin, a multidrug pump inhibitor

21 January 2018

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Prospects for plant-derived antibacterials.

21 January 2018

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Are natural products still the best source for antibacterial discovery? The bacterial entry factor.

21 January 2018

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An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site

21 January 2018

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Identification of novel antimicrobials using a live-animal infection model

21 January 2018

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Whole-animal high-throughput screens: the C. elegans model

21 January 2018

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New antibiotics from bacterial natural products

21 January 2018

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Prediction of mechanisms of action of antibacterial compounds by gene expression profiling.

21 January 2018

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Platensimycin is a selective FabF inhibitor with potent antibiotic properties

21 January 2018

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Complete set of ORF clones of Escherichia coli ASKA library (a complete set of E. coli K-12 ORF archive): unique resources for biological research

21 January 2018

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Discovery of FabH/FabF inhibitors from natural products

21 January 2018

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Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica.

21 January 2018

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Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)

21 January 2018

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Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis

21 January 2018

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A genomics-guided approach for discovering and expressing cryptic metabolic pathways.

21 January 2018

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The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus : identification of a target gene of the A-factor receptor

21 January 2018

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Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters

21 January 2018

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Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters.

21 January 2018

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Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

21 January 2018

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Strain improvement in actinomycetes in the postgenomic era.

21 January 2018

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The Uncultured Microbial Majority

21 January 2018

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Status of the Microbial Census

21 January 2018

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A study of iterative type II polyketide synthases, using bacterial genes cloned from soil DNA: a means to access and use genes from uncultured microorganisms

21 January 2018

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Isolation of antibiotics turbomycin a and B from a metagenomic library of soil microbial DNA

21 January 2018

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Isolating "uncultivable" microorganisms in pure culture in a simulated natural environment

21 January 2018

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A trap for in situ cultivation of filamentous actinobacteria

21 January 2018

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Use of ichip for high-throughput in situ cultivation of "uncultivable" microbial species

21 January 2018

1 reference

Siderophores from neighboring organisms promote the growth of uncultured bacteria

21 January 2018

1 reference

Incubation of environmental samples in a diffusion chamber increases the diversity of recovered isolates

21 January 2018

1 reference

Increased antifungal activity of L-733,560, a water-soluble, semisynthetic pneumocandin, is due to enhanced inhibition of cell wall synthesis

21 January 2018

1 reference

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent

21 January 2018

1 reference

Biological effects of cyclosporin A: A new antilymphocytic agent

21 January 2018

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Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

21 January 2018

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A Phase II trial of 17-allylamino, 17-demethoxygeldanamycin (17-AAG, tanespimycin) in patients with metastatic melanoma

21 January 2018

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Artemisinin: discovery from the Chinese herbal garden

21 January 2018

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Natural products and plant disease resistance

21 January 2018

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Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase

21 January 2018

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That Was Then But This Is Now: Malaria Research in the Time of an Eradication Agenda

21 January 2018

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Anti-staphylococcal plant natural products

21 January 2018

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Creation of a bacterial cell controlled by a chemically synthesized genome

21 January 2018

1 reference

Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America

21 January 2018

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Global spread of carbapenem-resistant Acinetobacter baumannii

21 January 2018

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Molecular mechanisms of antibacterial multidrug resistance

21 January 2018

1 reference

Persister cells, dormancy and infectious disease

21 January 2018

1 reference

21 January 2018

1 reference

Persister cells and tolerance to antimicrobials

21 January 2018

1 reference

Bacterial persistence as a phenotypic switch

21 January 2018

1 reference

Persisters: a distinct physiological state of E. coli

21 January 2018

1 reference

Specialized persister cells and the mechanism of multidrug tolerance in Escherichia coli

21 January 2018

1 reference

Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB

21 January 2018

1 reference

Bacterial persistence by RNA endonucleases

21 January 2018

1 reference

Role of global regulators and nucleotide metabolism in antibiotic tolerance in Escherichia coli

21 January 2018

1 reference

Patients with long-term oral carriage harbor high-persister mutants of Candida albicans

21 January 2018

1 reference

Emergence of Pseudomonas aeruginosa Strains Producing High Levels of Persister Cells in Patients with Cystic Fibrosis

21 January 2018

1 reference

Non-inherited antibiotic resistance.

21 January 2018

1 reference

The future challenges facing the development of new antimicrobial drugs.

21 January 2018

1 reference

The beta-lactamase threat in Enterobacteriaceae, Pseudomonas and Acinetobacter

21 January 2018

1 reference

Metallo-beta-lactamase IMP-18 is located in a class 1 integron (In96) in a clinical isolate of Pseudomonas aeruginosa from Mexico

21 January 2018

1 reference

Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-beta-lactam beta-lactamase inhibitor

21 January 2018

1 reference

Molecular characterization of metallo-beta-lactamase-producing Acinetobacter baumannii and Acinetobacter genomospecies 3 from Korea: identification of two new integrons carrying the bla(VIM-2) gene cassettes

21 January 2018

1 reference

Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study

21 January 2018

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Emr, an Escherichia coli locus for multidrug resistance

21 January 2018

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ZINC--a free database of commercially available compounds for virtual screening

21 January 2018

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The art and practice of structure-based drug design: A molecular modeling perspective

21 January 2018

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A comprehensive regulatory framework to address the unmet need for new antibacterial treatments.

21 January 2018

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Treatment with monoclonal antibodies against Clostridium difficile toxins

21 January 2018

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Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization

21 January 2018

1 reference

Therapeutic effect of (Z)-3-(2,5-dimethoxyphenyl)-2-(4-methoxyphenyl) acrylonitrile (DMMA) against Staphylococcus aureus infection in a murine model

21 January 2018

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21 January 2018

Plant defense peptides

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Lantibiotics: biosynthesis and biological activities of uniquely modified peptides from gram-positive bacteria

21 January 2018

1 reference

Antimicrobial peptides of multicellular organisms

21 January 2018

1 reference

Biofilm susceptibility to bacteriophage attack: the role of phage-borne polysaccharide depolymerase

21 January 2018

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Nongenetic individuality in the host-phage interaction

21 January 2018

1 reference

A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistant Pseudomonas aeruginosa ; a preliminary report of efficacy

21 January 2018

1 reference

Digoxin for the Treatment of Heart Failure

21 January 2018

1 reference

Susceptibility of anaerobic bacteria to the new streptogramin RP 59500 in vitro

21 January 2018

1 reference

Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket

31 March 2020

1 reference

Physicochemical properties of antibacterial compounds: implications for drug discovery

31 March 2020

1 reference

Prescription for an ailing pharmaceutical industry

31 March 2020

1 reference

Ciprofloxacin causes persister formation by inducing the TisB toxin in Escherichia coli

31 March 2020

1 reference

Naturally-occurring beta-lactamase inhibitors with antibacterial activity

31 March 2020

1 reference

In vitro management of hospital Pseudomonas aeruginosa biofilm using indigenous T7-like lytic phage

31 March 2020

1 reference

Phage-inspired antibiotics?

31 March 2020

1 reference

Some Properties of Penicillin-resistant Staphylococci.

31 March 2020

1 reference

12 December 2020

Effect of polymyxin B nonapeptide on daptomycin permeability and cell surface properties in Pseudomonas aeruginosa, Escherichia coli, and Pasteurella multocida.

1 reference

12 December 2020

A microbial hormone, A-factor, as a master switch for morphological differentiation and secondary metabolism in Streptomyces griseus

1 reference

12 December 2020

Efflux-mediated drug resistance in bacteria

1 reference

12 December 2020

Using ZINC to acquire a virtual screening library

1 reference

12 December 2020

Streptomycin, a substance exhibiting antibiotic activity against gram-positive and gram-negative bacteria. 1944.

1 reference

12 December 2020

Responsibilities and Opportunities of the Private Practitioner in Preventive Medicine

1 reference

12 December 2020

The A-factor, responsible for streptomycin biosynthesis by mutant strains of Actinomyces streptomycini

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD3975

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4 August 2017

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