(Q34686810)

3 August 2017

title

Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas (English)

1 reference

3 August 2017

Pemetrexed Indirectly Activates the Metabolic Kinase AMPK in Human Carcinomas (English)

1 reference

10.1158/0008-5472.CAN-10-1873

Crossref

DOI

https://api.crossref.org/works/10.1158/0008-5472.CAN-10-1873

20 November 2024

Scott B Rothbart

1 reference

3 August 2017

author name string

Alexandra C. Racanelli

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21159649

20 November 2024

Richard G. Moran

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21159649

20 November 2024

language of work or name

English

0 references

publication date

1 December 2010

1 reference

3 August 2017

15 December 2010

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21159649

full work available at URL

20 November 2024

https://aacrjournals.org/cancerres/article-pdf/70/24/10299/2644995/10299.pdf

file format

Portable Document Format

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21159649

http://cancerres.aacrjournals.org/cgi/content/abstract/70/24/10299

20 November 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21159649

https://europepmc.org/articles/PMC3059241

20 November 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21159649

https://europepmc.org/articles/PMC3059241?pdf=render

20 November 2024

file format

Portable Document Format

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21159649

https://doi.org/10.1158/0008-5472.can-10-1873

20 November 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21159649

https://aacrjournals.org/cancerres/article-pdf/70/24/10299/2644995/10299.pdf

20 November 2024

file format

Portable Document Format

1 reference

10.1158/0008-5472.CAN-10-1873

Crossref

DOI

https://api.crossref.org/works/10.1158/0008-5472.CAN-10-1873

20 November 2024

1 reference

3 August 2017

1 reference

3 August 2017

1 reference

3 August 2017

page(s)

10299-10309

1 reference

Maintenance therapy for advanced non-small cell lung cancer: current status, controversies, and emerging consensus.

3 August 2017

cites work

1 reference

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ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

7 July 2018

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Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer.

7 July 2018

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Approval summary: pemetrexed in the initial treatment of advanced/metastatic non-small cell lung cancer

7 July 2018

1 reference

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Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of rapamycin inhibition

7 July 2018

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Structural insight into the autoinhibition mechanism of AMP-activated protein kinase

7 July 2018

1 reference

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Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumor cell response to PI3K/mTOR inhibition

7 July 2018

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Somatic LKB1 mutations promote cervical cancer progression

7 July 2018

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Molecular mechanisms of mTOR-mediated translational control

7 July 2018

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Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

7 July 2018

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Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer

7 July 2018

1 reference

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

7 July 2018

1 reference

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Structural basis for AMP binding to mammalian AMP-activated protein kinase

7 July 2018

1 reference

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AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

7 July 2018

1 reference

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Defining the role of mTOR in cancer

7 July 2018

1 reference

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059241

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059241

Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059241

Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1.

7 July 2018

1 reference

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059241

Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

7 July 2018

1 reference

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Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059241

The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059241

FDA drug approval summaries: pemetrexed (Alimta).

7 July 2018

1 reference

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The LKB1 tumor suppressor negatively regulates mTOR signaling

7 July 2018

1 reference

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The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

7 July 2018

1 reference

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AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC

7 July 2018

1 reference

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Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene

7 July 2018

1 reference

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

7 July 2018

1 reference

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TSC2 mediates cellular energy response to control cell growth and survival

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059241

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059241

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

7 July 2018

1 reference

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Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

7 July 2018

1 reference

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

7 July 2018

1 reference

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Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

7 July 2018

1 reference

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Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059241

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059241

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059241

Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059241

Role of AMP-activated protein kinase in mechanism of metformin action

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059241

Regulation of translation initiation by FRAP/mTOR

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059241

Analysis of the role of the AMP-activated protein kinase in the response to cellular stress.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059241

A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059241

Preclinical cellular pharmacology of LY231514 (MTA): a comparison with methotrexate, LY309887 and raltitrexed for their effects on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059241

5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059241

5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059241

A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5- yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059241

Population pharmacokinetics of pemetrexed disodium (ALIMTA) in patients with cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059241

The mechanism of transport of the multitargeted antifolate (MTA) and its cross-resistance pattern in cells with markedly impaired transport of methotrexate.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059241

Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21159649

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21159649

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-10-1873

1 reference

3 August 2017

1 reference

3 August 2017

1 reference