(Q34683987)

3 August 2017

title

Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1. (English)

1 reference

3 August 2017

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1 reference

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Kazuma Ohyashiki

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3 August 2017

Tomohiro Umezu

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3 August 2017

Hiroko Tadokoro

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3 August 2017

Kenko Azuma

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3 August 2017

Seiichiro Yoshizawa

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3 August 2017

Junko H Ohyashiki

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3 August 2017

language of work or name

English

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publication date

15 October 2014

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3 August 2017

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inferred from page(s)

published in

Blood

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3 August 2017

volume

124

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3 August 2017

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3 August 2017

page(s)

3748-3757

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describes a project that uses

3 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4263983/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Upregulation of miR-135b is involved in the impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients

7 July 2018

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Microenvironmental regulation of tumor progression and metastasis

7 July 2018

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MicroRNA-135b and Its Circuitry Networks as Potential Therapeutic Targets in Colon Cancer

7 July 2018

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Therapeutic effects of autologous hematopoietic stem cell transplantation in multiple myeloma patients

7 July 2018

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Exosomes derived from hypoxic leukemia cells enhance tube formation in endothelial cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263983

MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1.

7 July 2018

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7 July 2018

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The hypoxia target adrenomedullin is aberrantly expressed in multiple myeloma and promotes angiogenesis.

7 July 2018

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Hypoxia-inducible factor (HIF)-1α suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263983

MicroRNA-135b acts as a tumor promoter by targeting the hypoxia-inducible factor pathway in genetically defined mouse model of head and neck squamous cell carcinoma

7 July 2018

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Understanding the hypoxic niche of multiple myeloma: therapeutic implications and contributions of mouse models.

7 July 2018

1 reference

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Hypoxic enhancement of exosome release by breast cancer cells.

7 July 2018

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Novel targeted therapies and combinations for the treatment of multiple myeloma

7 July 2018

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Expression of miR-21, miR-31, miR-96 and miR-135b is correlated with the clinical parameters of colorectal cancer

7 July 2018

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Downregulated plasma miR-92a levels have clinical impact on multiple myeloma and related disorders

7 July 2018

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7 July 2018

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Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features

7 July 2018

1 reference

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Biological aspects of angiogenesis in multiple myeloma.

7 July 2018

1 reference

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miR-135b mediates NPM-ALK-driven oncogenicity and renders IL-17-producing immunophenotype to anaplastic large cell lymphoma.

7 July 2018

1 reference

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Identification of Differentially Expressed MicroRNAs in Osteosarcoma

7 July 2018

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Angiogenesis and Multiple Myeloma

7 July 2018

1 reference

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The emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma.

7 July 2018

1 reference

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Treatment of relapsed and refractory multiple myeloma in the era of novel agents

7 July 2018

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The use of novel agents in the treatment of relapsed and refractory multiple myeloma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263983

Unraveling the biology of multiple myeloma disease: cancer stem cells, acquired intracellular changes and interactions with the surrounding micro-environment

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263983

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263983

Detection and specific targeting of hypoxic regions within solid tumors: current preclinical and clinical strategies

7 July 2018

1 reference

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Improved survival in multiple myeloma and the impact of novel therapies

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263983

Hypoxia inducible factor-1 independent pathways in tumor angiogenesis.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263983

Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263983

The pathophysiologic role of VEGF in hematologic malignancies: therapeutic implications

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263983

Molecular basis of angiogenesis and cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263983

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263983

Bone marrow angiogenesis and progression in multiple myeloma.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263983

Clinical drug resistance linked to interconvertible phenotypic and functional states of tumor-propagating cells in multiple myeloma.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263983

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263983

Role of the hypoxic bone marrow microenvironment in 5T2MM murine myeloma tumor progression.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263983

Increased bone marrow microvessel density in newly diagnosed multiple myeloma carries a poor prognosis

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263983

Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma

26 October 2018

1 reference

12 December 2020

Proangiogenic properties of human myeloma cells: production of angiopoietin-1 and its potential relationship to myeloma-induced angiogenesis

1 reference

12 December 2020

Human myeloma cells express the bone regulating gene Runx2/Cbfa1 and produce osteopontin that is involved in angiogenesis in multiple myeloma patients

1 reference

12 December 2020

Prognostic value of bone marrow angiogenesis in multiple myeloma

1 reference

12 December 2020

10.1182/BLOOD-2014-05-576116

Identifiers

DOI

1 reference

3 August 2017

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3 August 2017

1 reference