(Q34643692)

3 August 2017

title

Metallothioneins and zinc in cancer diagnosis and therapy (English)

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3 August 2017

1 reference

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3 August 2017

Sona Krizkova

0 references

Marie Stiborova

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Rene Kizek

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3 August 2017

Marketa Ryvolova

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3 August 2017

Jan Hrabeta

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3 August 2017

Tomas Eckschlager

series ordinal

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3 August 2017

language of work or name

English

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publication date

11 October 2012

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3 August 2017

published in

Drug Metabolism Reviews

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3 August 2017

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3 August 2017

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3 August 2017

page(s)

287-301

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DNA damage from micronutrient deficiencies is likely to be a major cause of cancer

3 August 2017

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Metallothionein in radiation exposure: its induction and protective role

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21 January 2018

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21 January 2018

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Expression pattern of metallothionein, MTF-1 nuclear translocation, and its dna-binding activity in zebrafish (Danio rerio) induced by zinc and cadmium

21 January 2018

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Metallothioneins in human tumors and potential roles in carcinogenesis

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Protective effect of metallothionein on oxidative stress-induced DNA damage

21 January 2018

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Catalysis of zinc transfer by D-penicillamine to secondary chelators

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Metallothionein protects DNA from oxidative damage

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21 January 2018

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Metallothionein: the multipurpose protein

21 January 2018

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Augmented humoral immune function in metallothionein-null mice.

21 January 2018

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ECRG2, a novel candidate of tumor suppressor gene in the esophageal carcinoma, interacts directly with metallothionein 2A and links to apoptosis

21 January 2018

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Fine mapping of a mouse metallothionein gene metal response element

21 January 2018

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Neuronal growth-inhibitory factor (metallothionein-3): structure-function relationships

21 January 2018

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RCAS1, MT, and vimentin as potential markers of tumor microenvironment remodeling.

21 January 2018

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The possible biological role of metallothionein in apoptosis.

21 January 2018

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Metallothioneins and cancer

21 January 2018

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The oxidative stress of zinc deficiency

21 January 2018

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Metallothionein isoform II expression in hyperplastic, dysplastic and neoplastic prostatic lesions

21 January 2018

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Neuronal growth-inhibitory factor (metallothionein-3): reactivity and structure of metal-thiolate clusters

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Potential role of p53 on metallothionein induction in human epithelial breast cancer cells

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Free radicals, antioxidants, and nutrition

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Metallothionein transfers zinc to mitochondrial aconitase through a direct interaction in mouse hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Zinc deficiency potentiates induction and progression of lingual and esophageal tumors in p53-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Efficacy of zinc treatment against iron-induced toxicity in rat hepatoma cell line H4-II-E-C3.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Zinc as an anti-tumor agent in prostate cancer and in other cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

The important role of the apoptotic effects of zinc in the development of cancers

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2012.725414

The neurobiology of zinc in health and disease

21 January 2018

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Zinc homeostasis and signaling in health and diseases: Zinc signaling

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Regulation of metallothionein gene expression

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Analysis of promoter methylation and its role in silencing metallothionein I gene expression in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Correlation between metallothionein (MT) expression and selected prognostic factors in ductal breast cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Insight to physiology and pathology of zinc(II) ions and their actions in breast and prostate carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1.

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Redox control and interplay between p53 isoforms: roles in the regulation of basal p53 levels, cell fate, and senescence

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Zinc binding and redox control of p53 structure and function.

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Zinc deficiency, DNA damage and cancer risk

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Zinc transporters and cancer: a potential role for ZIP7 as a hub for tyrosine kinase activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Interprotein metal exchange between transcription factor IIIa and apo-metallothionein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

21 January 2018

Cadmium and renal cancer

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Drug discovery with engineered zinc-finger proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Significance of metallothionein overexpression in human tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Toxicology of antisense therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Proliferative potential in nasopharyngeal carcinoma: correlations with metallothionein expression and tissue zinc levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Clinicopathological significance of metallothioneins in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Metallothionein 2A expression is associated with cell proliferation in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Zinc in innate and adaptive tumor immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Biochemistry of metallothionein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Immunosuppressant FK506 inhibits inducible nitric oxide synthase gene expression at a step of NF-kappaB activation in rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Localization of metallothionein in hair follicles of normal skin and the basal cell layer of hyperplastic epidermis: possible association with cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Human metallothionein genes are clustered on chromosome 16

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Basal and zinc-induced metallothionein in resistance to cadmium, cisplatin, zinc, and tertbutyl hydroperoxide: studies using MT knockout and antisense-downregulated MT in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Metallothionein-2A overexpression increases the expression of matrix metalloproteinase-9 and invasion of breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Zinc-induced NF-kappaB inhibition can be modulated by changes in the intracellular metallothionein level

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

In vitro and in vivo studies on the degradation of metallothionein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Metallothionein protection of cadmium toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Megalin mediates renal uptake of heavy metal metallothionein complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Metallothioneins and platinum(II) anti-tumor compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Zn7metallothionein-3 and the synaptic vesicle cycle: interaction of metallothionein-3 with the small GTPase Rab3A.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

High-dose dietary zinc promotes prostate intraepithelial neoplasia in a murine tumor induction model

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

DNA microarray analysis of altered gene expression in cadmium-exposed human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Zinc finger transcription factor Zn3-Sp1 reactions with Cd2+.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Thionein/metallothionein control Zn(II) availability and the activity of enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Utilizing of Adsorptive Transfer Stripping Technique Brdicka Reaction for Determination of Metallothioneins Level in Melanoma Cells, Blood Serum and Tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Electrophoretic fingerprint metallothionein analysis as a potential prostate cancer biomarker

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Immunoextraction of zinc proteins from human plasma using chicken yolk antibodies immobilized onto paramagnetic particles and their electrophoretic analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Zinc finger proteins as molecular targets for nitric oxide-mediated gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Serum-induced expression of metallothionein isoforms in K-562 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Protein-protein interaction of zinc finger LIM domains with protein kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Silencing the Metallothionein-2A gene induces entosis in adherent MCF-7 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Targeting Metallothionein for Prognosis and Treatment of Breast Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Hydrogen sulfide-releasing NSAIDs attenuate neuroinflammation induced by microglial and astrocytic activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Revisit of field cancerization in squamous cell carcinoma of upper aerodigestive tract: better risk assessment with epigenetic markers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

The involvement of metallothioneins in mitochondrial function and disease

21 January 2018

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Role of oxidative stress in cadmium toxicity and carcinogenesis

21 January 2018

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Cadmium as a transcriptional modulator in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Antioxidant micronutrients and childhood malignancy during oncological treatment

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Zinc coordination environments in proteins determine zinc functions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Inhibitory sites in enzymes: zinc removal and reactivation by thionein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Cellular zinc and redox buffering capacity of metallothionein/thionein in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Enzyme regulation by reversible zinc inhibition: glycerol phosphate dehydrogenase as an example

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

A CADMIUM PROTEIN FROM EQUINE KIDNEY CORTEX

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Isolation of metallothionein from cells derived from aggressive form of high-grade prostate carcinoma using paramagnetic antibody-modified microbeads off-line coupled with electrochemical and electrophoretic analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

The two faces of metallothionein in carcinogenesis: photoprotection against UVR-induced cancer and promotion of tumour survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

In vitro degradation of apo-, zinc-, and cadmium-metallothionein by cathepsins B, C, and D

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Induction, regulation, degradation, and biological significance of mammalian metallothioneins.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Zinc, metallothioneins, immune responses, survival and ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Exogenous metallothionein-IIA promotes accelerated healing after a burn wound.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Functional metal ions in nucleic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Intracellular zinc homeostasis and zinc signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Cell cycle regulation of metallothionein in human colonic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Mechanisms of drug resistance in chemotherapy for urogenital carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Mammalian metallothionein in toxicology, cancer, and cancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Metallothionein expression in HaCaT and C6 cell lines exposed to cadmium.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Tesmin transcription is regulated differently during male and female meiosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Redox Environment and its Meaning for Breast Cancer Cells Fate

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Interaction of metallothionein with tumor suppressor p53 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

P53 mediated regulation of metallothionein transcription in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Effect of transition metals on binding of p53 protein to supercoiled DNA and to consensus sequence in DNA fragments.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Overexpression of metallothionein-II sensitizes rodent cells to apoptosis induced by DNA cross-linking agent through inhibition of NF-kappa B activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

The role of metallothionein in oncogenesis and cancer prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

The essential toxin: impact of zinc on human health

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Gene targeting using zinc finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Reactive oxygen species modulate Zn(2+)-induced apoptosis in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Metallothionein 2A interacts with the kinase domain of PKCμ in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Modulation of DNA binding of a tramtrack zinc finger peptide by the metallothionein-thionein conjugate pair

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Genomic analysis, cytokine expression, and microRNA profiling reveal biomarkers of human dietary zinc depletion and homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Oxygen free radicals and metallothionein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Cisplatin resistance in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Building a metal-responsive promoter with synthetic regulatory elements

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Nitric oxide modulation of the growth and differentiation of freshly isolated acute non-lymphocytic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Isolation of GIF from porcine brain and studies of its zinc transfer kinetics with apo-carbonic anhydrase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Metallothionein-induced increase in mitochondrial inner membrane permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Immunohistochemical localization of metallothionein and p53 protein in pancreatic serous cystadenomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Differential expression of metallothionein in gastrointestinal stromal tumors and gastric carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Nitric oxide-induced changes in intracellular zinc homeostasis are mediated by metallothionein/thionein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Nuclear trafficking of metallothionein requires oxidation of a cytosolic partner

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Application of phi29 motor pRNA for targeted therapeutic delivery of siRNA silencing metallothionein-IIA and survivin in ovarian cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Metallothionein expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patient survival

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Metallothionein expression in human neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Metallothionein: A Multifunctional Protein from Toxicity to Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Metallothionein: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

A Review of Metallothionein Isoforms and their Role in Pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

New markers for pancreatic islets and islet cell tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Proteins expressed in osteosarcoma and serum levels as prognostic factors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Zinc fingers, zinc clusters, and zinc twists in DNA-binding protein domains

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Chemistry and biology of mammalian metallothioneins.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Cadmium and prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Molecular and cellular mechanisms of cadmium carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Interaction of tumor suppressor p53 with DNA and proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Involvement of metallothionein and copper in cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Redox protein expression predicts progression-free and overall survival in ovarian cancer patients treated with platinum-based chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Studies of interaction of tumor suppressor p53 with apo-MT using surface plasmon resonance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Zinc metallothionein imported into liver mitochondria modulates respiration

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Metallothionein mediates leukocyte chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Metallothionein-induced suppression of cytotoxic T lymphocyte function: an important immunoregulatory control

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Zinc transfer from transcription factor IIIA fingers to thionein clusters

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Matrix metalloproteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

Levels of selenium, zinc, copper, and antioxidant enzyme activity in patients with leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

The Physiological Roles of Extracellular Metallothionein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.725414

10.3109/03602532.2012.725414

21 January 2018

Identifiers

DOI

1 reference

3 August 2017

1 reference