(Q34588342)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17150968%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

title

Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17150968%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17150968%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17150968%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

Claude Libert

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17150968%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

Mary Kaileh

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17150968%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

Julie Horion

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17150968%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

Jacques Piette

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17150968%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

Denis De Keukeleire

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17150968%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

Tamer Essawi

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17150968%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

Guy Haegeman

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17150968%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

language of work or name

English

0 references

publication date

6 December 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17150968%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

22 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17150968%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

volume

282

1 reference

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22 December 2019

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17150968%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

page(s)

4253-4264

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17150968%20AND%20SRC:MED&resulttype=core&format=json

From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer.

22 December 2019

cites work

1 reference

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Antimicrobial activity of 20 plants used in folkloric medicine in the Palestinian area

21 January 2018

1 reference

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Ethnobotanical knowledge of local Arab practitioners in the Middle Eastern region

21 January 2018

1 reference

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Screening of some Palestinian medicinal plants for antibacterial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Effect of Withania somnifera on DMBA induced carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

The NF-kappa B and I kappa B proteins: new discoveries and insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

21 January 2018

Signaling to NF-kappaB

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

21 January 2018

Nuclear factor-kappa B.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

NF-kappaB activation in cancer: a challenge for ubiquitination- and proteasome-based therapeutic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

NF-kappaB: tumor promoter or suppressor?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Dissection of the NF-kappaB signalling cascade in transgenic and knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

A20 inhibits NF-kappaB activation by dual ubiquitin-editing functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Hsp70 promotes TNF-mediated apoptosis by binding IKK gamma and impairing NF-kappa B survival signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Human T-lymphotropic virus type I tax activates I-kappa B kinase by inhibiting I-kappa B kinase-associated serine/threonine protein phosphatase 2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

The nuclear factor-kappaB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

A fully dissociated compound of plant origin for inflammatory gene repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Recombination signal sequence binding protein Jkappa is constitutively bound to the NF-kappaB site of the interleukin-6 promoter and acts as a negative regulatory factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Glucocorticoid-mediated repression of nuclear factor-kappaB-dependent transcription involves direct interference with transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Attenuation of mitogen- and stress-activated protein kinase-1-driven nuclear factor-kappaB gene expression by soy isoflavones does not require estrogenic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

RelA/p65 regulation of IkappaBbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Direct Phosphorylation of IB by IKK and IKK: Discrimination Between Free and NF-B-Bound Substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

ERK is an anti-inflammatory signal that suppresses expression of NF-kappaB-dependent inflammatory genes by inhibiting IKK activity in endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

IkappaB kinase is an essential component of the Tpl2 signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

The essential role of MEKK3 in TNF-induced NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Development of withaferin A analogs as probes of angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Jesterone dimer, a synthetic derivative of the fungal metabolite jesterone, blocks activation of transcription factor nuclear factor kappaB by inhibiting the inhibitor of kappaB kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Transcriptional regulation via cysteine thiol modification: a novel molecular strategy for chemoprevention and cytoprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Binding of manumycin A inhibits IkappaB kinase beta activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Suppression of interleukin-6 production in macrophages by furonaphthoquinone NFD-37.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

4-isoavenaciolide covalently binds and inhibits VHR, a dual-specificity phosphatase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

MKP-8, a novel MAPK phosphatase that inhibits p38 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Novel hydroxyl naphthoquinones with potent Cdc25 antagonizing and growth inhibitory properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Identification and H2O2 sensitivity of the major constitutive MAPK phosphatase from rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemot

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Inhibition of protein phosphatase 2A activity by selective electrophile alkylation damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Enhanced dephosphorylation of cAMP-dependent protein kinase by oxidation and thiol modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Essential role of MAPK phosphatase-1 in the negative control of innate immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

The IKK NF-kappa B system: a treasure trove for drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Growth inhibition of human tumor cell lines by withanolides from Withania somnifera leaves

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Withaferin A is a potent inhibitor of angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

Suberoylanilide hydroxamic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing nuclear factor-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

RelB/p50 Dimers Are Differentially Regulated by Tumor Necrosis Factor-α and Lymphotoxin-β Receptor Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606728200

21 January 2018

Identifiers

DOI

10.1074/JBC.M606728200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17150968%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17150968%20AND%20SRC:MED&resulttype=core&format=json