(Q34579804)

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Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

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Annette Dolphin

13

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Europe PubMed Central

PubMed publication ID

3 August 2017

author name string

Mark J Field

1

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Europe PubMed Central

PubMed publication ID

3 August 2017

Peter J Cox

2

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Europe PubMed Central

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3 August 2017

Emma Stott

3

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Heather Melrose

4

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

James Offord

5

1 reference

Europe PubMed Central

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3 August 2017

Ti-Zhi Su

6

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Steve Bramwell

7

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Laura Corradini

8

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Steven England

9

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Joanna Winks

10

1 reference

Europe PubMed Central

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3 August 2017

Ross A Kinloch

11

1 reference

Europe PubMed Central

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3 August 2017

Jan Hendrich

12

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Tony Webb

14

1 reference

Europe PubMed Central

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3 August 2017

Dic Williams

15

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Europe PubMed Central

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3 August 2017

language of work or name

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publication date

6 November 2006

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Europe PubMed Central

PubMed publication ID

3 August 2017

Proceedings of the National Academy of Sciences of the United States of America

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Europe PubMed Central

PubMed publication ID

3 August 2017

103

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Europe PubMed Central

PubMed publication ID

3 August 2017

46

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

17537-17542

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

The calcium channel alpha2delta-2 subunit partitions with CaV2.1 into lipid rafts in cerebellum: implications for localization and function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

The metal-ion-dependent adhesion site in the Von Willebrand factor-A domain of alpha2delta subunits is key to trafficking voltage-gated Ca2+ channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

Structure-activity relationships of pregabalin and analogues that target the alpha(2)-delta protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

Calcium channel alpha2delta subunits: differential expression, function, and drug binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

Auxiliary subunits: essential components of the voltage-gated calcium channel complex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

Pregabalin: a new anxiolytic

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

An overview of neuropathic pain: syndromes, symptoms, signs, and several mechanisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

Pain perception in mice lacking the beta3 subunit of voltage-activated calcium channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

Pregabalin (Pfizer).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

The anticonvulsant, antihyperalgesic agent gabapentin is an agonist at brain gamma-aminobutyric acid type B receptors negatively coupled to voltage-dependent calcium channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

Suppression of inflammatory and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

Transgenic studies of pain and analgesia: mutation or background genotype?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

Structure and regulation of voltage-gated Ca2+ channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

Placebo-controlled study of gabapentin treatment of panic disorder

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

Peripheral neuropathic pain: from mechanisms to symptoms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

Altered pain responses in mice lacking alpha 1E subunit of the voltage-dependent Ca2+ channel.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

Structural requirement of the calcium-channel subunit alpha2delta for gabapentin binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

Treatment of social phobia with gabapentin: a placebo-controlled study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

Construction of gene targeting vectors from lambda KOS genomic libraries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

3-substituted GABA analogs with central nervous system activity: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

Structure and function of neuronal Ca2+ channels and their role in neurotransmitter release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

Cloning and deletion mutagenesis of the alpha2 delta calcium channel subunit from porcine cerebral cortex. Expression of a soluble form of the protein that retains [3H]gabapentin binding activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

A summary of mechanistic hypotheses of gabapentin pharmacology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

Gabapentin (neurontin) and S‐(+)‐3‐isobutylgaba represent a novel class of selective antihyperalgesic agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

Comparison of the autoradiographic binding distribution of [3H]-gabapentin with excitatory amino acid receptor and amino acid uptake site distributions in rat brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

FACS-optimized mutants of the green fluorescent protein (GFP)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

Dynorphin A selectively reduces a large transient (N-type) calcium current of mouse dorsal root ganglion neurons in cell culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

Promoter-cDNA-directed heterologous protein expression in Xenopus laevis oocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

The formalin test: an evaluation of the method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

Heterogeneous calcium currents and transmitter release in cultured mouse spinal cord and dorsal root ganglion neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

7 July 2018

Pregabalin for the treatment of postherpetic neuralgia: a randomized, placebo-controlled trial

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0409066103

21 January 2018

Gabapentin is not a GABAB receptor agonist

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0409066103

21 January 2018

The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0409066103

21 January 2018

Localization of [3H]gabapentin to a novel site in rat brain: autoradiographic studies

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0409066103

21 January 2018

Dual function of the voltage-dependent Ca2+ channel alpha 2 delta subunit in current stimulation and subunit interaction.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0409066103

21 January 2018

Effects of Presurgical Local Infiltration of Bupivacaine in the Surgical Field on Postsurgical Wound Pain in Laparoscopic Gynecologic Examinations: A Possible Preemptive Analgesic Effect

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0409066103

21 January 2018

Gabapentin and the neurokinin(1) receptor antagonist CI-1021 act synergistically in two rat models of neuropathic pain

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0409066103

21 January 2018

Injury type-specific calcium channel alpha 2 delta-1 subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0409066103

21 January 2018

Gabapentin inhibits the substance P-facilitated K(+)-evoked release of [(3)H]glutamate from rat caudial trigeminal nucleus slices

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0409066103

21 January 2018

Further evidence for the role of the alpha(2)delta subunit of voltage dependent calcium channels in models of neuropathic pain

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0409066103

21 January 2018

Dominant-negative calcium channel suppression by truncated constructs involves a kinase implicated in the unfolded protein response.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0409066103

21 January 2018

Upregulation of dorsal root ganglion (alpha)2(delta) calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1859964

27 October 2018

Detection of static and dynamic components of mechanical allodynia in rat models of neuropathic pain: are they signalled by distinct primary sensory neurones?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17088553

12 December 2020

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10.1073/PNAS.0409066103

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

2006PNAS..10317537F

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

ResearchGate publication ID

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