(Q34577169)

3 August 2017

title

Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance (English)

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3 August 2017

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R C Bonadonna

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3 August 2017

R A DeFronzo

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3 August 2017

E Ferrannini

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3 August 2017

L C Groop

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3 August 2017

S DelPrato

series ordinal

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3 August 2017

K Ratheiser

series ordinal

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3 August 2017

K Zyck

series ordinal

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3 August 2017

language of work or name

English

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publication date

1 July 1989

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Journal of Clinical Investigation

3 August 2017

published in

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3 August 2017

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3 August 2017

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3 August 2017

page(s)

205-213

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The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

3 August 2017

cites work

2 references

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7 July 2018

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Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus

27 October 2018

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The antilipolytic effect of insulin in human adipose tissue in obesity, diabetes mellitus, hyperinsulinemia, and starvation

7 July 2018

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Stimulation of gluconeogenesis by palmitic acid in rat hepatocytes: evidence that this effect can be dissociated from the provision of reducing equivalents

7 July 2018

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Differential effects of insulin therapy on hepatic and peripheral insulin sensitivity in Type 2 (non-insulin-dependent) diabetes

7 July 2018

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Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects

7 July 2018

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Insulin Binding and Responsiveness in Fat Cells from Patients with Reduced Glucose Tolerance and Type II Diabetes

7 July 2018

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New concepts in the pathogenesis and treatment of noninsulin-dependent diabetes mellitus

7 July 2018

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Regulation of hepatic fatty acid oxidation and ketone body production

7 July 2018

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Effect of fatty acids on glucose production and utilization in man

7 July 2018

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Turnover rate of plasma FFA in humans and in dogs

7 July 2018

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Effect of glucose ingestion on the metabolism of free fatty acids in human subjects

7 July 2018

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Measurement and validation of nonsteady turnover rates with applications to the inulin and glucose systems.

7 July 2018

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Uptake of individual free fatty acids by skeletal muscle and liver in man

7 July 2018

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Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver

7 July 2018

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Relation of fatty acid oxidation tgluconeogenesis: effect of pentenoic acid.

7 July 2018

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Role of free fatty acids in glucose homeostasis

7 July 2018

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Ambient plasma free fatty acid concentrations in noninsulin-dependent diabetes mellitus: evidence for insulin resistance

7 July 2018

1 reference

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Multiple disturbances of free fatty acid metabolism in noninsulin-dependent diabetes. Effect of oral hypoglycemic therapy

7 July 2018

1 reference

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Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus

7 July 2018

1 reference

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Relationship between insulin-mediated glucose disposal and lipid metabolism in man.

7 July 2018

1 reference

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Validation of a new method for determination of free fatty acid turnover

7 July 2018

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Non-steady state: error analysis of Steele's model and developments for glucose kinetics.

7 July 2018

1 reference

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Regulation of hepatic glucose metabolism in humans

7 July 2018

1 reference

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Role of lipid oxidation in pathogenesis of insulin resistance of obesity and type II diabetes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303971

Relationships between plasma-free fatty acid concentration, endogenous glucose production, and fasting hyperglycemia in normal and non-insulin-dependent diabetic individuals

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303971

The theoretical bases of indirect calorimetry: a review

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303971

Radioimmunological determination of human C-peptide in serum

7 July 2018

1 reference

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Proinsulin, insulin, and C-peptide concentrations in human portal and peripheral blood

7 July 2018

1 reference

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Free fatty acid oxidation by forearm muscle at rest, and evidence for an intramuscular lipid pool in the human forearm

7 July 2018

1 reference

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Evidence for marked sensitivity to the antilipolytic action of insulin in obese maturity-onset diabetics

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303971

Glucose clamp technique: a method for quantifying insulin secretion and resistance

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303971

Immunoassay of insulin with insulin-antibody precipitate

7 July 2018

1 reference

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Postreceptor defects causing insulin resistance in normoinsulinemic non-insulin-dependent diabetes mellitus.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303971

Hepatic and peripheral insulin resistance: a common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus

27 October 2018

1 reference

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Carbohydrate Oxidation and Storage in Obese Non-insulin-dependent Diabetic Patients: Effects of Improving Glycemic Control

27 October 2018

1 reference

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Resistance to insulin suppression of plasma free fatty acid concentrations and insulin stimulation of glucose uptake in noninsulin-dependent diabetes mellitus

27 October 2018

1 reference

12 December 2020

Human Forearm Muscle Metabolism during Exercise VII. FFA Uptake and Oxidation at Different Work Intensities

1 reference

12 December 2020

Operation of the "glucose-fatty acid cycle" during experimental elevations of plasma free fatty acid levels in man

1 reference

12 December 2020

Turnover of individual free fatty acids in man

1 reference

12 December 2020

Glucose turnover values in the dog obtained with various species of labeled glucose

1 reference

12 December 2020

Effect of hyperglycemia independent of changes in insulin or glucagon on lipolysis in the conscious dog

1 reference

12 December 2020

Glucose storage and oxidation in different degrees of human obesity measured by continuous indirect calorimetry

1 reference

12 December 2020

The effect of graded doses of insulin on total glucose uptake, glucose oxidation, and glucose storage in man

1 reference

12 December 2020

Regulation of Splanchnic and Peripheral Glucose Uptake by Insulin and Hyperglycemia in Man

1 reference

12 December 2020

A microfluorometric method for the determination of free fatty acids in plasma

1 reference

12 December 2020

Influence of parenteral carbohydrate on fat oxidation in surgical patients

1 reference

12 December 2020

Glucose storage is a major determinant of in vivo "insulin resistance" in subjects with normal glucose tolerance

1 reference

12 December 2020

An abnormality of nonesterified fatty acid metabolism in diabetes mellitus

1 reference

12 December 2020

Factors influencing the rates of long-chain fatty acid oxidation and synthesis in mammalian systems

1 reference

12 December 2020

SOURCE OF FAT OXIDATION IN EXERCISING DOGS

1 reference

12 December 2020

The Relationship Between Serum Free Fatty Acids and Blood Sugar in Non-obese and Obese Diabetics

1 reference

12 December 2020

Oxidation of plasma FFA in lean and obese humans

1 reference

12 December 2020

Metabolic factors in the insulin resistance in human obesity

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI114142

1 reference

3 August 2017

1 reference

3 August 2017

1 reference