(Q34575350)

3 August 2017

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title

Epitope spreading in immune-mediated diseases: implications for immunotherapy (English)

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3 August 2017

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Carol L Vanderlugt

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3 August 2017

Stephen D Miller

series ordinal

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3 August 2017

publication date

1 February 2002

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Nature Reviews Immunology

3 August 2017

published in

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3 August 2017

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3 August 2017

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3 August 2017

page(s)

85-95

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Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

3 August 2017

cites work

1 reference

Determinant spreading and the dynamics of the autoimmune T-cell repertoire.

31 March 2020

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Shifting T-cell activation thresholds in autoimmunity and determinant spreading

31 March 2020

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Despite epitope spreading in the pathogenesis of autoimmune disease, highly restricted approaches to immune therapy may still succeed [with a hedge on this bet]

31 March 2020

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A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: a basis for peptide-specific therapy after onset of clinical disease

31 March 2020

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The functional significance of epitope spreading and its regulation by co-stimulatory molecules

31 March 2020

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Determinant spreading during experimental autoimmune encephalomyelitis: is it potentiating, protecting or participating in the disease?

31 March 2020

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The epitope spreading cascade during progression of experimental autoimmune encephalomyelitis and multiple sclerosis

31 March 2020

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Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis

31 March 2020

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Pathologic role and temporal appearance of newly emerging autoepitopes in relapsing experimental autoimmune encephalomyelitis

31 March 2020

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High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire

31 March 2020

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Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE

31 March 2020

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Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis

31 March 2020

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CTLA-4 downregulates epitope spreading and mediates remission in relapsing experimental autoimmune encephalomyelitis

31 March 2020

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Regression and spreading of self-recognition during the development of autoimmune demyelinating disease

31 March 2020

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Disease-modifying drugs for relapsing-remitting multiple sclerosis and future directions for multiple sclerosis therapeutics

31 March 2020

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Immunologic therapy of multiple sclerosis

31 March 2020

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Modulation of the IL-10/IL-12 cytokine circuit by interferon-beta inhibits the development of epitope spreading and disease progression in murine autoimmune encephalomyelitis

31 March 2020

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Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes

31 March 2020

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Diversity and plasticity of self recognition during the development of multiple sclerosis

31 March 2020

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Spontaneous regression of primary autoreactivity during chronic progression of experimental autoimmune encephalomyelitis and multiple sclerosis

31 March 2020

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Repertoire dynamics of autoreactive T cells in multiple sclerosis patients and healthy subjects: epitope spreading versus clonal persistence.

31 March 2020

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Epidemiologic evidence for multiple sclerosis as an infection

31 March 2020

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Virus-induced autoimmunity: potential role of viruses in initiation, perpetuation, and progression of T-cell-mediated autoimmune disease

31 March 2020

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Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading

31 March 2020

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Temporal development of autoreactive Th1 responses and endogenous presentation of self myelin epitopes by central nervous system-resident APCs in Theiler's virus-infected mice

31 March 2020

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Endogenous presentation of self myelin epitopes by CNS-resident APCs in Theiler's virus-infected mice

31 March 2020

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Investigation of the role of delayed-type-hypersensitivity responses to myelin in the pathogenesis of Theiler's virus-induced demyelinating disease.

31 March 2020

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Myelin-specific tolerance attenuates the progression of a virus-induced demyelinating disease: implications for the treatment of MS.

31 March 2020

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Type I diabetes mellitus. A chronic autoimmune disease

31 March 2020

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The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD.

31 March 2020

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Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

31 March 2020

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Characterization of Novel T-cell Epitopes on 65kDa and 67kDa Glutamic Acid Decarboxylase Relevant in Autoimmune Responses in NOD Mice

31 March 2020

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Characterization of immunodominant peptide determinants of IDDM-associated autoantigens in the NOD mouse.

31 March 2020

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Determinant Spreading of T Helper Cell 2 (Th2) Responses to Pancreatic Islet Autoantigens

31 March 2020

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Epitope dominance: evidence for reciprocal determinant spreading to glutamic acid decarboxylase in non-obese diabetic mice

31 March 2020

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Infectious Th1 and Th2 autoimmunity in diabetes-prone mice.

31 March 2020

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Autoimmune diabetes: the role of T cells, MHC molecules and autoantigens

31 March 2020

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Maturation of the humoral autoimmune response to epitopes of GAD in preclinical childhood type 1 diabetes

31 March 2020

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Epitope spreading and a varying but not disease-specific GAD65 antibody response in Type I diabetes. The Childhood Diabetes in Finland Study Group

31 March 2020

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Modulation of humoral islet autoimmunity by pancreas allotransplantation influences allograft outcome in patients with type 1 diabetes

31 March 2020

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Determinant spreading and immune responses to acetylcholine receptors in myasthenia gravis

31 March 2020

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Response to human acetylcholine receptor alpha 138-199: determinant spreading initiates autoimmunity to self-antigen in rabbits

31 March 2020

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Presentation by myoblasts of an epitope from endogenous acetylcholine receptor indicates a potential role in the spreading of the immune response

31 March 2020

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Anti-CTLA-4 antibody treatment triggers determinant spreading and enhances murine myasthenia gravis

31 March 2020

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Anti-titin antibodies in myasthenia gravis: tight association with thymoma and heterogeneity of nonthymoma patients

31 March 2020

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Heat-shock protein T-cell epitopes trigger a spreading regulatory control in a diversified arthritogenic T-cell response.

31 March 2020

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Identification of autoantigen epitopes in MHC class II transgenic mice.

31 March 2020

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Diversification of T cell responses to carboxy-terminal determinants within the 65-kD heat-shock protein is involved in regulation of autoimmune arthritis

31 March 2020

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Diversification of response to hsp65 during the course of autoimmune arthritis is regulatory rather than pathogenic.

31 March 2020

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Autoreactivity to human heat-shock protein 60 predicts disease remission in oligoarticular juvenile rheumatoid arthritis.

31 March 2020

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T-Cell reactivity to human HSP60 in oligo-articular juvenile chronic arthritis is associated with a favorable prognosis and the generation of regulatory cytokines in the inflamed joint

31 March 2020

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Juvenile chronic arthritis: T cell reactivity to human HSP60 in patients with a favorable course of arthritis

31 March 2020

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Indirect T cell recognition in allograft rejection

31 March 2020

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Intramolecular and intermolecular spreading during the course of organ allograft rejection

31 March 2020

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Persistent allopeptide reactivity and epitope spreading in chronic rejection of organ allografts

31 March 2020

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Persisting viruses and chronic inflammation: understanding their relation to autoimmunity

31 March 2020

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Prevention and reversal of experimental autoimmune myasthenia gravis by a monoclonal antibody against acetylcholine receptor-specific T cells.

31 March 2020

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Antigen-driven peripheral immune tolerance: suppression of experimental autoimmmune encephalomyelitis and collagen-induced arthritis by aerosol administration of myelin basic protein or type II collagen.

31 March 2020

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Hierarchy in the ability of T cell epitopes to induce peripheral tolerance to antigens from myelin

31 March 2020

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A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens

31 March 2020

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Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand

31 March 2020

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T Helper 2 (Th2) T Cells Induce Acute Pancreatitis and Diabetes in Immune-compromised Nonobese Diabetic (NOD) Mice

31 March 2020

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Myelin Basic Protein–specific T Helper 2 (Th2) Cells Cause Experimental Autoimmune Encephalomyelitis in Immunodeficient Hosts Rather than Protect Them from the Disease

31 March 2020

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Evidence for epitope spreading and active suppression in skin graft tolerance after donor-specific transfusion

31 March 2020

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Regulating the immune response to transplants. a role for CD4+ regulatory cells?

31 March 2020

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MHC class I-restricted epitope spreading in the context of tumor rejection following vaccination with a single immunodominant CTL epitope

31 March 2020

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Epitope spreading upon P815 tumor rejection triggered by vaccination with the single class I MHC-restricted peptide P1A

31 March 2020

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Enhancement of antitumor immunity by CTLA-4 blockade

31 March 2020

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CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma.

31 March 2020

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A virus-induced molecular mimicry model of multiple sclerosis

31 March 2020

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Immune responses, and autoimmune outcome, during virus infection of the central nervous system

31 March 2020

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Molecular mimicry between a viral peptide and a myelin oligodendrocyte glycoprotein peptide induces autoimmune demyelinating disease in mice.

31 March 2020

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Evidence for mimicry by viral antigens in animal models of autoimmune disease including myocarditis

31 March 2020

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From infection to autoimmunity

31 March 2020

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Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry

31 March 2020

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Molecular mimicry by herpes simplex virus-type 1: autoimmune disease after viral infection.

31 March 2020

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Herpes simplex virus-induced keratitis: evaluation of the role of molecular mimicry in lesion pathogenesis

31 March 2020

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Targeting the B7/CD28:CTLA-4 costimulatory system in CNS autoimmune disease

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI724

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3 August 2017

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