(Q34573001)

3 August 2017

title

Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis (English)

1 reference

3 August 2017

Vinita Takiar

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21262823

22 November 2024

Kenneth R. Hallows

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21262823

22 November 2024

Michael J. Caplan

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21262823

22 November 2024

Saori Nishio

1 reference

3 August 2017

Patricia Seo-Mayer

1 reference

3 August 2017

Hui Li

1 reference

3 August 2017

Li Zhang

1 reference

3 August 2017

Anil Karihaloo

1 reference

3 August 2017

Stefan Somlo

1 reference

3 August 2017

J. Darwin King

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21262823

22 November 2024

language of work or name

English

0 references

publication date

24 January 2011

1 reference

full work available at URL

3 August 2017

https://europepmc.org/articles/pmc3038735?pdf=render

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21262823

https://europepmc.org/articles/PMC3038735

22 November 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21262823

https://europepmc.org/articles/PMC3038735?pdf=render

22 November 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21262823

https://doi.org/10.1073/pnas.1011498108

22 November 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21262823

https://pnas.org/doi/pdf/10.1073/pnas.1011498108

22 November 2024

1 reference

DOI

10.1073/PNAS.1011498108

https://api.crossref.org/works/10.1073/PNAS.1011498108

Proceedings of the National Academy of Sciences of the United States of America

22 November 2024

published in

1 reference

3 August 2017

volume

108

1 reference

3 August 2017

1 reference

3 August 2017

page(s)

2462-2467

1 reference

Metformin activates AMP kinase through inhibition of AMP deaminase

3 August 2017

cites work

1 reference

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7 July 2018

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Calcimimetic inhibits late-stage cyst growth in ADPKD

7 July 2018

1 reference

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AMP-activated protein kinase phosphorylation of the R domain inhibits PKA stimulation of CFTR.

7 July 2018

1 reference

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Acidosis in the hospital setting: is metformin a common precipitant?

7 July 2018

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Vegf as an epithelial cell morphogen modulates branching morphogenesis of embryonic kidney by directly acting on the ureteric bud.

7 July 2018

1 reference

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Structural and functional analyses of liver cysts from the BALB/c-cpk mouse model of polycystic kidney disease

7 July 2018

1 reference

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038735

Small-molecule CFTR inhibitors slow cyst growth in polycystic kidney disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038735

Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038735

A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038735

Dose translation from animal to human studies revisited

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038735

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038735

Metformin and body weight

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038735

Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038735

AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038735

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038735

Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038735

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038735

Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized renal epithelial cells.

7 July 2018

1 reference

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The relationship between cell proliferation, Cl- secretion, and renal cyst growth: a study using CFTR inhibitors

7 July 2018

1 reference

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TSC2 mediates cellular energy response to control cell growth and survival

7 July 2018

1 reference

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Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038735

Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038735

Regulation of channel gating by AMP-activated protein kinase modulates cystic fibrosis transmembrane conductance regulator activity in lung submucosal cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038735

The cystic fibrosis transmembrane conductance regulator (CFTR) inhibits ENaC through an increase in the intracellular Cl- concentration

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038735

Role of AMP-activated protein kinase in mechanism of metformin action

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038735

Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase

7 July 2018

1 reference

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The TOR signaling cascade regulates gene expression in response to nutrients

7 July 2018

1 reference

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7 July 2018

1 reference

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Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038735

Expression vector system based on the chicken beta-actin promoter directs efficient production of interleukin-5.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038735

Renal epithelial cyst formation and enlargement in vitro: dependence on cAMP.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3038735

Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD).

7 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1011498108

Physiological modulation of CFTR activity by AMP-activated protein kinase in polarized T84 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1011498108

Activation of AMP-activated protein kinase reduces cAMP-mediated epithelial chloride secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1011498108

Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1011498108

A Cre recombinase transgene with mosaic, widespread tamoxifen-inducible action

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1011498108

AMPK controls epithelial Na(+) channels through Nedd4-2 and causes an epithelial phenotype when mutated

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1011498108

cAMP-dependent activation of CFTR inhibits the epithelial sodium channel (ENaC) without affecting its surface expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1011498108

Regulated ion transport in mouse liver cyst epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1011498108

Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1011498108

Acute renal ischemia rapidly activates the energy sensor AMPK but does not increase phosphorylation of eNOS-Ser1177.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1011498108

Epithelial-specific Cre/lox recombination in the developing kidney and genitourinary tract.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1011498108

The cystic fibrosis transmembrane conductance regulator mediates transepithelial fluid secretion by human autosomal dominant polycystic kidney disease epithelium in vitro

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21262823

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cystic fibrosis and the phenotypic expression of autosomal dominant polycystic kidney disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21262823

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Early embryonic renal tubules of wild-type and polycystic kidney disease kidneys respond to cAMP stimulation with cystic fibrosis transmembrane conductance regulator/Na(+),K(+),2Cl(-) Co-transporter-dependent cystic dilation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21262823

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1011498108

1 reference

3 August 2017

0 references

1 reference

3 August 2017

1 reference