(Q34554750)

3 August 2017

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title

Multiparameter analyses of cell cycle regulatory proteins in human breast cancer: a key to definition of separate pathways in tumorigenesis (English)

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3 August 2017

Göran Landberg

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3 August 2017

publication date

1 January 2002

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Advances in Cancer Research

3 August 2017

published in

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3 August 2017

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3 August 2017

page(s)

35-56

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p27kip1 expression in breast carcinomas: An immunohistochemical study on 512 patients with long-term follow-up

3 August 2017

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Induction of mammary gland hyperplasia and carcinomas in transgenic mice expressing human cyclin E

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Frequency of homozygous deletion at p16/CDKN2 in primary human tumours

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7 January 2021

Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer

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7 January 2021

The cyclin dependent kinase inhibitor p27 and its prognostic role in breast cancer.

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p107 and p130: versatile proteins with interesting pockets

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7 January 2021

Cyclin gene amplification and overexpression in breast and ovarian cancers: Evidence for the selection ofcyclin D1 in breast andcyclin E in ovarian tumors

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Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway

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7 January 2021

Cyclin E in human cancers.

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7 January 2021

Cyclin E immunoexpression in breast ductal carcinoma: pathologic correlations and prognostic implications

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7 January 2021

Stabilization of cyclin D1 mRNA via the phosphatidylinositol 3-kinase pathway in MCF-7 human breast cancer cells.

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7 January 2021

Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation

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7 January 2021

Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.

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7 January 2021

Prognostic implications of p27 and cyclin E protein contents in malignant lymphomas

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7 January 2021

Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

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7 January 2021

p27(kip1) acts as a downstream effector of and is coexpressed with the beta1C integrin in prostatic adenocarcinoma

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7 January 2021

Multifaceted regulation of cell cycle progression by estrogen: regulation of Cdk inhibitors and Cdc25A independent of cyclin D1-Cdk4 function

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7 January 2021

Abnormal expression of cell cycle regulatory proteins in ductal and lobular carcinomas of the breast

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7 January 2021

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function

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7 January 2021

Tumour-suppressor genes: evolving definitions in the genomic age

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7 January 2021

The Hallmarks of Cancer

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7 January 2021

Inhibition of cyclin-dependent kinases by p21

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7 January 2021

Commitment and effector phases of the physiological cell death pathway elucidated with respect to Bcl-2 caspase, and cyclin-dependent kinase activities

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7 January 2021

Translational control of p27Kip1 accumulation during the cell cycle

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7 January 2021

Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1

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7 January 2021

Transgenic mouse models of human breast cancer

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7 January 2021

Gene Expression and Cell Cycle Arrest Mediated by Transcription Factor DMP1 Is Antagonized by D-Type Cyclins through a Cyclin-Dependent-Kinase-Independent Mechanism

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7 January 2021

Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation.

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7 January 2021

New functional activities for the p21 family of CDK inhibitors

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7 January 2021

Regulation of the functional interaction between cyclin D1 and the estrogen receptor

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7 January 2021

The cell cycle in breast cancer

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7 January 2021

Downregulation of the potential suppressor gene IGFBP-rP1 in human breast cancer is associated with inactivation of the retinoblastoma protein, cyclin E overexpression and increased proliferation in estrogen receptor negative tumors

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7 January 2021

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

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7 January 2021

Cyclin E dependent kinase activity in human breast cancer in relation to cyclin E, p27 and p21 expression and retinoblastoma protein phosphorylation

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7 January 2021

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

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7 January 2021

P/CAF associates with cyclin D1 and potentiates its activation of the estrogen receptor

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7 January 2021

Expression of cell cycle-regulatory proteins rb, p16/MTS1, p27/KIP1, p21/WAF1, cyclin D1 and cyclin E in breast cancer: correlations with expression of activating protein-1 family members

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7 January 2021

A U-rich element in the 5' untranslated region is necessary for the translation of p27 mRNA.

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7 January 2021

Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

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7 January 2021

Cell-free degradation of p27(kip1), a G1 cyclin-dependent kinase inhibitor, is dependent on CDK2 activity and the proteasome

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7 January 2021

Cyclin E overexpression, a negative prognostic factor in breast cancer with strong correlation to oestrogen receptor status

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7 January 2021

Deregulation of cyclin E and D1 in breast cancer is associated with inactivation of the retinoblastoma protein

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7 January 2021

G1-S transition defects occur in most breast cancers and predict outcome

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7 January 2021

Methylation of the p16(Ink4a) tumor suppressor gene 5'-CpG island in breast cancer

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7 January 2021

Human cyclin E, a nuclear protein essential for the G1-to-S phase transition

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7 January 2021

Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells

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7 January 2021

Molecular portraits of human breast tumours

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7 January 2021

p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2984002-7

7 January 2021

Estrogen-dependent cyclin E-cdk2 activation through p21 redistribution

1 reference

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7 January 2021

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2984002-7

7 January 2021

Novel splice variants of cyclin E with altered substrate specificity

1 reference

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7 January 2021

Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients

1 reference

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7 January 2021

c-Myc or cyclin D1 mimics estrogen effects on cyclin E-Cdk2 activation and cell cycle reentry

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7 January 2021

DNA methylation regulates p27kip1 expression in rodent pituitary cell lines

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7 January 2021

p16(MTS-1/CDKN2/INK4a) in cancer progression

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https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2984002-7

7 January 2021

Involvement of Myc activity in a G(1)/S-promoting mechanism parallel to the pRb/E2F pathway

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https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2984002-7

7 January 2021

The INK4A/ARF locus and its two gene products

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7 January 2021

Cyclin E-CDK2 is a regulator of p27Kip1.

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2984002-7

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7 January 2021

Immunodetectable cyclin D(1)is associated with oestrogen receptor but not Ki67 in normal, cancerous and precancerous breast lesions

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https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2984002-7

7 January 2021

Cyclin D1 provides a link between development and oncogenesis in the retina and breast

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7 January 2021

Deregulated cyclin E induces chromosome instability

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7 January 2021

Cyclins and breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2984002-7

7 January 2021

Cooperation of p27(Kip1) and p18(INK4c) in progestin-mediated cell cycle arrest in T-47D breast cancer cells.

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https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2984002-7

7 January 2021

Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1

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https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2984002-7

7 January 2021

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

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7 January 2021

PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2984002-7

7 January 2021

Differential expression of p16/p21/p27 and cyclin D1/D3, and their relationships to cell proliferation, apoptosis, and tumour progression in invasive ductal carcinoma of the breast

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2984002-7

7 January 2021

MAT1-modulated CAK activity regulates cell cycle G(1) exit

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2984002-7

7 January 2021

Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFbeta, and contact inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2984002-7

7 January 2021

The retinoblastoma gene: a prototypic and multifunctional tumor suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2984002-7

7 January 2021

Cyclin D1 overexpression in a model of human breast premalignancy: preferential stimulation of anchorage-independent but not anchorage-dependent growth is associated with increased cdk2 activity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2984002-7

7 January 2021

CDK-independent activation of estrogen receptor by cyclin D1

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2984002-7

7 January 2021

Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2802%2984002-7

7 January 2021

10.1016/S0065-230X(02)84002-7

Identifiers

DOI

1 reference

3 August 2017

1 reference